Grantee Research Project Results
2009 Progress Report: Gastrointestinal TSLP in the Pathogenesis of Food Allergy
EPA Grant Number: R834064Title: Gastrointestinal TSLP in the Pathogenesis of Food Allergy
Investigators: Berin, M. Cecilia
Institution: Mount Sinai School of Medicine
EPA Project Officer: Aja, Hayley
Project Period: December 1, 2008 through November 30, 2010 (Extended to November 30, 2011)
Project Period Covered by this Report: December 8, 2008 through December 7,2009
Project Amount: $466,125
RFA: Exploratory Investigations in Food Allergy (2007) RFA Text | Recipients Lists
Research Category:
Objective:
We aim to improve toxicity testing for novel proteins in animals by studying the role in the gut of a protein biomarker, thymic stromal lymphopoietin (TSLP), with a central role in allergic inflammation.
Progress Summary:
In this project period, we have undertaken studies to determine the role of TSLP in allergy and tolerance in the gastrointestinal tract. We have determined that TSLP is necessary for a model of allergic inflammation localized to the gastrointestinal tract, but is not required for primary allergic sensitization or immune tolerance generated via the intestinal mucosa. Our mechanistic studies show that TSLP is required for the induction of pathogenic Th2-producing T cells, and that the target of action of TSLP is on the memory T cell. Therefore, we conclude that TSLP plays an important role in the amplification of allergic sensitization into allergic disease in the gastrointestinal tract.
Future Activities:
- Assessment of the regulation of TSLP expression by human intestinal epithelial cells.
- Assessment of the role of TSLP as an initiator of allergic sensitization to food proteins.
Journal Articles on this Report : 2 Displayed | Download in RIS Format
| Other project views: | All 11 publications | 10 publications in selected types | All 10 journal articles |
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Blazquez AB, Knight AK, Getachew H, Bromberg JS, Lira SA, Mayer L, Berin MC. A functional role for CCR6 on proallergic T cells in the gastrointestinal tract. Gastroenterology 2010;138(1):275-284. |
R834064 (2009) R834064 (Final) |
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Blazquez AB, Mayer L, Berin MC. Thymic stromal lymphopoietin is required for gastrointestinal allergy but not oral tolerance. Gastroenterology 2010;139(4):1301-1309. |
R834064 (2009) R834064 (Final) |
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Supplemental Keywords:
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.