Grantee Research Project Results

2006 Progress Report: Carbon-Carbon Bond Formations in Water and Other Alternative Media

EPA Grant Number: R831662
Title: Carbon-Carbon Bond Formations in Water and Other Alternative Media
Investigators: Li, Chao-Jun
Institution: Tulane University
EPA Project Officer: Richards, April
Project Period: June 1, 2004 through June 1, 2008
Project Period Covered by this Report: June 1, 2005 through June 1, 2006
RFA: Technology for a Sustainable Environment (2003) RFA Text | Recipients Lists
Research Category: Pollution Prevention/Sustainable Development , Sustainable and Healthy Communities

Objective:

The overall objective of this research is to explore novel chemical reactivities for more efficient and environmentally benign chemical synthesis in cleaner reaction media. In particular, the research is directed towards novel C-C bond formation reactions—the essence of chemical syntheses.

Progress Summary:

In the last funding period on this project, we have accomplished the following achievements:

A one-step efficient tandem reaction to generate vinyl-indole derivatives catalyzed by gold was developed;
An efficient direct coupling of C-H and C-H bond under neat conditions and without using a metal catalyst was developed;
An efficient method for green separation of products from reactions in water was developed (to be published);
A direct C-C bond formation using alkanes was developed (submitted for publication).

Future Activities:

During the no-cost extension period, we will further optimize the exciting results on the efficient functionalization of alkanes and the isolation technique for aqueous reactions.

Journal Articles on this Report : 3 Displayed | Download in RIS Format

Publications Views
Other project views:	All 138 publications	29 publications in selected types	All 27 journal articles

Publications
Type	Citation	Project	Document Sources
Journal Article	Li C-J, Chen L. Organic chemistry in water. Chemical Society Reviews 2006;35(1):68-82.	R831662 (2006) R831662 (Final)	Full-text: ResearchGate-Abstract Exit Abstract: RSC-Abstract Exit Other: ResearchGate-Full Text PDF Exit
Journal Article	Zhang Y, Li C-J. Highly efficient cross-dehydrogenative-coupling between ethers and active methlyene compounds. Angewandte Chemie International Edition 2006;45(12):1949-1952.	R831662 (2006) R831662 (Final)	Abstract from PubMed Abstract: Wiley-Abstract Exit
Journal Article	Zhang Y, Donahue JP, Li C-J. Gold(III)-catalyzed double hydroamination of o-alkynylaniline with terminal alkynes leading to N-vinylindoles. Organic Letters 2007;9(4):627-630.	R831662 (2006) R831662 (Final)	Abstract from PubMed Abstract: ACS-Abstract Exit

Supplemental Keywords:

C-C Bond Formation, Cleaner Reaction Media, Cleaner Synthesis,, Sustainable Industry/Business, cleaner production/pollution prevention

Progress and Final Reports:

Original Abstract

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.