Grantee Research Project Results

Center for Children’s Environmental Health Research – CHAMACOS Community Based Research Project

EPA Grant Number: R831710C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R831710
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Integrative Research on Childhood Leukemia and the Environment - 2015
Center Director: Metayer, Catherine
Title: Center for Children’s Environmental Health Research – CHAMACOS Community Based Research Project
Investigators: Eskenazi, Brenda , Tager, Ira , Lipsett, Michael , Alkon, Abbey , Johnson, Caroline , Macher, Janet , Sedgwick, Jaqueline , Tunzi, Mark , Cuevas, Maximiliano , Minkler, Meredith , Boyce, Thomas
Institution: University of California - Berkeley
EPA Project Officer: Callan, Richard
Project Period: May 1, 2004 through October 31, 2008 (Extended to October 31, 2010)
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health

Objective:

The Community-Based Prevention Research (CBPR) component of the Center is the CHAMACOS birth cohort study of the potential health effects of pesticide and allergen exposures to pregnant women and their children. The specific aims of the project are to determine whether organophosphate pesticide exposure in utero and/or during the postnatal period is associated at preschool and school-age with: 1) poorer neurodevelopment and behavioral performance; 2) slower somatic growth; 3) atopy, active asthma or asthma-like symptoms, and airway reactivity; and, 4) autonomic nervous system dysfunction. We are also investigating the relationship between environmental antigens and respiratory outcomes in our populations.

Approach:

OP exposure will be defined by levels of six non-specific OP metabolites measured in urine collected from mothers at enrollment, 26-weeks gestation, and postpartum, and from children at 6-, 12-, 24-, 42-, and 60-months of age. Exposures related to respiratory outcomes will be assessed by home inspection, questionnaire, and, for a subset of children, measurements of allergens and endotoxin in children’s homes. We will assess growth and perform a battery of neuropsychological assessments (e.g., cognition, memory, attention, motor) of the children at 42- and 60-months, and obtain teacher and parent evaluation of behavior and school performance at 84-months. We will assess respiratory health by questionnaire, medical record review, blood analysis of IgE and Th1 and Th2 cytokines, and tests of lung function and airway reactivity at 60-months.

Expected Results:

This research will enhance our knowledge of the health and development of these hard-to-reach low-income Latino children living in agricultural areas and provide critical information on the health effects of organophosphate pesticide exposure to children for the U.S. Environmental Protection Agency’s implementation of the Food Quality Protection Act.

Publications and Presentations:

Publications have been submitted on this subproject: View all 25 publications for this subproject | View all 170 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 23 journal articles for this subproject | View all 136 journal articles for this center

Supplemental Keywords:

endocrine disruptor, wheeze, neurodevelopment, ANS, FQPA, organophosphate,, RFA, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, PESTICIDES, HUMAN HEALTH, Health Risk Assessment, Health Effects, Children's Health, Pesticide Types, Risk Assessment, asthma, pesticide exposure, community-based intervention, airway disease, environmental risks, respiratory problems, Human Health Risk Assessment, insecticides, assessment of exposure, childhood respiratory disease, environmental health hazard, children's environmental health, outreach and education, agricultural community, allergen

Progress and Final Reports:

Main Center Abstract and Reports:

R831710 Center for Integrative Research on Childhood Leukemia and the Environment - 2015

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R831710C001 Center for Children’s Environmental Health Research – CHAMACOS Community Based Research Project
R831710C002 Center for Children’s Environmental Health Research – Pesticide Exposure Assessment Project
R831710C003 Center for Children’s Environmental Health Research – Mechanisms of Pesticide Neuro- and Immunotoxicity
R831710C004 Center for Children’s Environmental Health Research – Community Outreach and Translation Core

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.