Grantee Research Project Results
2004 Progress Report: Nanomaterial-Based Microchip Assays For Continuous Environmental Monitoring
EPA Grant Number: R830900Title: Nanomaterial-Based Microchip Assays For Continuous Environmental Monitoring
Investigators: Wang, Joseph
Institution: New Mexico State University - Main Campus
EPA Project Officer: Hahn, Intaek
Project Period: June 1, 2003 through May 31, 2006
Project Period Covered by this Report: June 1, 2004 through May 31, 2005
Project Amount: $341,000
RFA: Environmental Futures Research in Nanoscale Science Engineering and Technology (2002) RFA Text | Recipients Lists
Research Category: Nanotechnology , Human Health , Safer Chemicals
Objective:
The objective of this research project is to address the needs for innovative nanotechnological tools for continuous environmental monitoring of priority pollutants. The project aims to create a novel nanomaterial-based submersible microfluidic device for the rapid, continuous, and cost-effective monitoring of different classes of priority pollutants. We wish to exploit the unique properties of metal nanoparticles and carbon nanotubes for enhancing the separation and detection processes, respectively, in microchip environmental assays. We also wish to understand the relationship between the physical and chemical properties of these nanomaterials and observed behavior. The miniaturized “Laboratory-on-a-Cable” will incorporate all the steps of the analytical protocol into a submersible, remotely deployed device.
Progress Summary:
The dramatic downscaling and integration of chemical assays make microchip devices extremely attractive as environmental screening tools and hold considerable promise for faster and simpler onsite monitoring of priority pollutants. During Year 2 of the project, we developed several powerful microchip protocols and electrochemical detection schemes for environmental monitoring of several important groups of pollutants. The resulting “Lab-on-a-Chip” assays coupled fast separation with highly sensitive detection of these major contaminants. The utility of new (diamond) electrode materials and surface modifiers (phthalocyanine) for such microchip detection also was demonstrated. We continued our fundamental studies on the utility of carbon nanotubes for enhancing electronic sensing and detection. This effort has been very successful and resulted in several important publications. These developments indicate that microchip devices coupled with nanomaterials hold great promise for field monitoring of priority pollutants.
Future Activities:
We will examine the use of different nanomaterials (nanoparticles and nanowires) for enhancing different elements of “Lab-on-a-Chip” devices and will design a submersible microfluidic device for rapidly, continuously, and economically monitoring different classes of priority pollutants.
Journal Articles on this Report : 13 Displayed | Download in RIS Format
Other project views: | All 19 publications | 13 publications in selected types | All 13 journal articles |
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Chen G, Wang J. Fast and simple sample introduction for capillary electrophoresis microsystems. Analyst 2004;129(6):507-511. |
R830900 (2003) R830900 (2004) |
not available |
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Deo RP, Wang J, Block I, Mulchandani A, Joshi KA, Trojanowicz M, Scholz F, Chen W, Lin YH. Determination of organophosphate pesticides at a carbon nanotube/organophosphorus hydrolase electrochemical biosensor. Analytica Chimica Acta 2005;530(2):185-189 |
R830900 (2004) |
not available |
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Ding Y, White CA, Muralidhara S, Bruckner JV, Bartlett MG. Determination of deltamethrin and its metabolite 3-phenoxybenzoic acid in male rat plasma by high-performance liquid chromatography. Journal of Chromatography B 2004;810(2):221-227. |
R830900 (2004) R830800 (2003) R830800 (2004) R830800 (2005) R830800 (2006) R830800 (Final) |
Exit Exit Exit |
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Ding Y, White CA, Bruckner JV, Bartlett MG. Determination of deltamethrin and its metabolites, 3-phenoxybenzoic acid and 3-phenoxybenzyl alcohol, in maternal plasma, amniotic fluid, and placental and fetal tissues by HPLC. Journal of Liquid Chromatography & Related Technologies 2004;27(12):1875-1892. |
R830900 (2004) R830800 (2003) R830800 (2004) R830800 (2005) R830800 (2006) R830800 (Final) |
Exit |
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Lawrence NS, Deo RP, Wang J. Electrochemical determination of hydrogen sulfide at carbon nanotube modified electrodes. Analytica Chimica Acta 2004;517(1-2):131-137 |
R830900 (2003) R830900 (2004) |
not available |
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Musameh M, Lawrence N, Wang J. Electrochemical activation of carbon nanotubes. Electrochemistry Communications 2005(1);7:14-18. |
R830900 (2004) |
not available |
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Scampicchio M, Wang J, Mannino S, Chatrathi MP. Microchip capillary electrophoresis with amperometric detection for rapid separation and detection of phenolic acids. Journal of Chromatography A 2004;1049(1-2):189-194. |
R830900 (2004) |
not available |
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Schoning MJ, Jacobs M, Muck A, Knobbe DT, Wang J, Chatrathi M, Spillmann S. Amperometric PDMS/glass capillary electrophoresis-based biosensor microchip for catechol and dopamine detection. Sensors and Actuators B-Chemical 2005;108(1-2):688-694 |
R830900 (2004) |
not available |
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Shin DC, Tryk DA, Fujishima A, Muck A, Chen G, Wang J. Microchip capillary electrophoresis with a boron-doped diamond electrochemical detector for analysis of aromatic amines. Electrophoresis 2004;25(17):3017-3023 |
R830900 (2004) |
not available |
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Wang J, Chen G, Chatrathi MP, Musameh M. Capillary electrophoresis microchip with a carbon nanotube-modified electrochemical detector. Analytical Chemistry 2004;76(2):298-302 |
R830900 (2003) R830900 (2004) |
not available |
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Wang J, Chen G, Wang M, Chatrathi MP. Carbon-nanotube/copper composite electrodes for capillary electrophoresis microchip detection of carbohydrates. Analyst 2004;129(6):512-515 |
R830900 (2003) R830900 (2004) |
not available |
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Wang J, Zima J, Lawrence NS, Chatrathi MP, Mulchandani A, Collins GE. Microchip capillary electrophoresis with electrochemical detection of thiol-containing degradation products of V-type nerve agents. Analytical Chemistry 2004;76(16):4721-4726. |
R830900 (2004) |
not available |
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Wang J, Chen G, Muck A, Chatrathi M, Mulchandani A, Chen W. Microchip enzymatic assay of organophosphate nerve agents. Analytica Chimica Acta 2004; 505(1): 183-187. |
R830900 (2003) R830900 (2004) |
not available |
Supplemental Keywords:
nanotechnology, nanomaterials, microchip, environmental monitoring, carbon nanotubes, sensor, continuous monitoring, environmental measurement, microchip assays, nanocontact sensor, nanoengineering, nanosensors,, RFA, Scientific Discipline, Water, Ecosystem Protection/Environmental Exposure & Risk, Sustainable Industry/Business, Monitoring/Modeling, Environmental Monitoring, New/Innovative technologies, Engineering, Chemistry, & Physics, Environmental Engineering, nanosensors, continous monitoring, environmental measurement, carbon nanotubes, continuous monitoring, nanotechnology, microchip assays, analytical chemistry, nanocontact sensorRelevant Websites:
http://www.public.asu.edu/~jwang85 Exit
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.