Grantee Research Project Results
Ultrafine Oil Aerosol Generation for Inhalation Studies
EPA Grant Number: R827354C008Subproject: this is subproject number 008 , established and managed by the Center Director under grant R827354
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: HSRC (1989) - Northeast HSRC
Center Director: Sidhu, Sukh S.
Title: Ultrafine Oil Aerosol Generation for Inhalation Studies
Investigators: Veranth, John , Oberdörster, Günter , Gelein, Robert
Current Investigators: Veranth, John
Institution: University of Utah , University of Rochester
Current Institution: University of Utah
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2004 (Extended to May 31, 2006)
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Particulate Matter , Air Quality and Air Toxics , Air
Objective:
The objective of this research project is to design and validate an ultrafine aerosol generator for hydrocarbon aerosols to use in inhalation studies usinglaboratory animals. The particle generator will be used to do a controlled exposure of rats to organic carbon aerosol, a surrogate for the organic component of internal combustion engine tailpipe emissions.
Approach:
This project will focus on the design and validation of an ultrafine aerosol generator. The generator will produce aerosol from used motor oil, and the aerosol will be characterization to assess the number and size distribution. Particle sampling data will be collected to determine whether the generator meets the criteria of having greater than 1 x 106 particles / cm3 with a count median diameter between 30-50 nm.
Expected Results:
We expect to develop an aerosol generator with the ability to work with complex mixtures such as used motor oil. With this generator, animal inhalation exposure studies can lead to new findings in cardiovascular health problems related to particulate matter.
Supplemental Keywords:
ultrafine organic aerosol, aerosol, motor oil, hydrocarbon aerosol, inhalation, animal., RFA, Health, Air, Scientific Discipline, PHYSICAL ASPECTS, Waste, Health Risk Assessment, Physical Processes, Risk Assessments, Air Pollution, particulate matter, Environmental Chemistry, Incineration/Combustion, Epidemiology, Molecular Biology/Genetics, Air Pollution Effects, Atmospheric Sciences, Biochemistry, Air Pollutants, air toxics, aerosol, aerosols, health effects, sensitive populations, urban air pollution, human health, epidemelogy, ambient monitoring, particle size, pulmonary disease, urban environment, coronary artery disease, fine particles, human exposure, risk assessment, ambient air monitoring, cardiopulmonary responses, cardiovascular vulnerability, lung, pulmonary, animal model, particulate exposure, environmental health effects, exposure, particulates, susceptible populations, ambient air, inhalation toxicology, combustion engines, ambient air quality, cardiopulmonary, cardiovascular disease, human health effects, human health risk, metals, lung inflamation, atmospheric, PM2.5, ultrafine particlesProgress and Final Reports:
Main Center Abstract and Reports:
R827354 HSRC (1989) - Northeast HSRC Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827354C001 Characterization of the Chemical Composition of Atmospheric Ultrafine Particles
R827354C002 Inflammatory Responses and Cardiovascular Risk Factors in Susceptible Populations
R827354C003 Clinical Studies of Ultrafine Particle Exposure in Susceptible Human Subjects
R827354C004 Animal Models: Dosimetry, and Pulmonary and Cardiovascular Events
R827354C005 Ultrafine Particle Cell Interactions: Molecular Mechanisms Leading to Altered Gene Expression
R827354C006 Development of an Electrodynamic Quadrupole Aerosol Concentrator
R827354C007 Kinetics of Clearance and Relocation of Insoluble Ultrafine Iridium Particles From the Rat Lung Epithelium to Extrapulmonary Organs and Tissues (Pilot Project)
R827354C008 Ultrafine Oil Aerosol Generation for Inhalation Studies
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.