Grantee Research Project Results
Inner City Toxicants and Neurodevelopmental Impairment
EPA Grant Number: R827039Center: Center for Research on Early Childhood Exposure and Development in Puerto Rico
Center Director: Alshawabkeh, Akram
Title: Inner City Toxicants and Neurodevelopmental Impairment
Investigators: Wolff, Mary S.
Institution: Mount Sinai School of Medicine
EPA Project Officer: Callan, Richard
Project Period: August 1, 1998 through July 31, 2003 (Extended to July 31, 2004)
Project Amount: $3,136,392
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
Environmental Toxicants and Neuro-Developmental Impairment in Inner City Children is the unifying scientific theme of the Mount Sinai Center for Children's Environmental Health and Disease Prevention Research. This Center resides within the Department of Community and Preventive Medicine, in the Division of Environmental Health Science.
Children living in poverty in inner-city communities suffer some of the heaviest exposures to environmental toxicants in the United States. The goals of the Mount Sinai Center for Children's Environmental Health and Disease Prevention Research are (1) to identify linkages between environmental toxicants and neuro-developmental dysfunction in inner-city children; (2) to elucidate the pathogenic mechanisms by which environmental toxicants can cause developmental impairment; and (3) to prevent neuro-developmental dysfunction of environmental origin in urban children.
The research and prevention programs of the Center will focus on a range of neurodevelopmental toxicants encountered in the inner city: (1) pesticides-legal insecticides such as chlorpyrifos, and illegal "street" pesticides such as methyl Darathion. tres pasitos and tiza china; (2) polychlorinated biphenyls (PCBs); and (3) lead. Patterns of exposure to these toxicants will be assessed. Adverse developmental outcomes will be examined through epidemiological studies and will include loss of intelligence, delayed attainment of developmental milestones, alteration of behavior and diminished life achievement; potential linkages of these problems to environmental exposures will be studied and etiologic mechanisms elucidated. New aDDroaches to prevention will be evaluated.
The Center includes five interdisciplinary research projects that link epidemiological and basic biological research at the Mount Sinai Medical Center and the New York Academy of Medicine's Center of Urban Epidemiologic Studies with the Boriken Neighborhood Health Center, with the East Harlem Community Health Committee and with an extensive network of community-based organizations in East Harlem.
Journal Articles: 33 Displayed | Download in RIS Format
| Other center views: | All 41 publications | 34 publications in selected types | All 33 journal articles |
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Berkowitz GS, Wolff MS, Matte T, Susser E, Landrigan PJ. The rationale for a national prospective cohort study of environmental exposure and childhood development. Environmental Research 2001;85(2):59-68. |
R827039 (2002) R827039C004 (2002) |
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Berkowitz GS, Obel J, Deych E, Lapinski R, Godbold J, Liu Z, Landrigan PJ, Wolff MS. Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort. Environmental Health Perspectives 2003;111(1):79-84. |
R827039 (2002) R827039C004 (2002) R831711 (2004) R831711 (2005) R831711 (2006) R831711 (2007) R831711 (Final) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Brenner B. Implementing a community intervention program for health promotion. Social Work in Health Care 2002;35(1-2):359-379. |
R827039 (2002) |
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Carpenter DO, Chew FT, Damstra T, Lam LH, Landrigan PJ, Makalinao I, Peralta GL, Suk WA. Environmental threats to the health of children:the Asian perspective. Environmental Health Perspectives 2000;108(10):989-992. |
R827039 (2002) |
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Chen J, Germer S, Higuchi R, Berkowitz G, Godbold J, Wetmur JG. Kinetic polymerase chain reaction on pooled DNA:a high-throughput, high-efficiency alternative in genetic epidemiological studies. Cancer Epidemiology, Biomarkers & Prevention 2002;11(1):131-136. |
R827039 (2002) R827039C001 (2002) |
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Claudio L, Torres T, Sanjurjo E, Sherman L, Landrigan PJ. Environmental health sciences education-a tool for achieving environmental equity and protecting children. Environmental Health Perspectives 1998;106(Supplement 3):849-855. |
R827039 (2002) |
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Engel S, Bradman A, Wolf M, Rauh V. Prenatal Organophosphor Pesticide Exposure and Child Neurodevelopment at 24 Months:An Analysis of Four Birth Cohorts. ENVIRONMENTAL HEALTH PERSPECTIVES 2016;124(6):822-830. |
R827039 (2002) R826709 (2002) R826886 (2000) R827027 (2002) R828609 (Final) R832141 (Final) |
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Erichsen HC, Engel SM, Eck PK, Welch R, Yeager M, Levine M, Siega-Riz AM, Olshan AF, Chanock SJ. Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery. American Journal of Epidemiology 2006;163(3):245-254. |
R827039 (2002) |
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Etzel TM, Engel SM, Quiros-Alcala L, Chen J, Barr DB, Wolff MS, BUckley JP. Prenatal maternal organophosphorus pesticide exposures, paraoxonase 1, and childhood adiposity in the Mount Sinai Children's Environmental Health Study. Environmental International 2020;142. |
R827039 (2002) R831711 (Final) |
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Flores G, Fuentes-Afflick E, Barbot O, Carter-Pokras O, Claudio L. The health of Latino children: urgent priorities, unanswered questions, and a research agenda. Journal of the American Medical Association 2002;288(1):82-90. |
R827039 (2002) |
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Forman J, Moline J, Cernichiari E, Sayegh S, Torres J, Landrigan M, Hudson J, Adel H, Landrigan P. A cluster of pediatric metallic mercury cases tracked with meso-2,3-Dimercaptosuccinic acid (DMSA). Environmental Health Perspectives 2000;108(6):575-577. |
R827039 (2002) |
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Gore AC. Environmental toxicant effects on neuroendocrine function. Endocrine 2001;14(2):235-246. |
R827039 (2002) R827039C002 (2002) |
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Gore AC. Organochlorine pesticides directly regulate gonadotropin-releasing hormone gene expression and biosynthesis in the GT1-7 hypothalamic cell line. Molecular and Cellular Endocrinology 2002;192(1-2):157-170. |
R827039 (2002) R827039C002 (2002) |
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Gore AC, Wu TJ, Oung T, Lee JB, Woller MJ. A novel mechanism for endocrine-disrupting effects of polychlorinated biphenyls: direct effects on gonadotropin-releasing hormone neurones. Journal of Neuroendocrinology 2002;14(10):814-823. |
R827039 (2002) R827039C002 (2002) |
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Harley KG, Engel SM, Vedar MG, Eskenazi B, Whyatt RM, Lanphear BP, Bradman A, Rauh VA, Yolton K, Hornung RW, Wetmur JG, Chen J, Holland NT, Barr DB, Perera FP, Wolff MS. Prenatal exposure to organophosphorous pesticides and fetal growth: pooled results from four longitudinal birth cohort studies. Environmental Health Perspectives 2016;124(7):1084-1092. |
R827039 (2002) R826709 (2002) R826886 (2000) R827027 (2002) R828609 (Final) R831710 (Final) R832141 (Final) R834513C001 (2015) |
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Hiatt R, Stewart S, Deardoff J, Danial E, Abiwahab E, Pinney S, Teitelbaum S, Windham G, Wolff M, Kushi L, Biro F. Childhood Socioeconomic Status and Menarche:A Prospective Study. Journal of Adolescent Health 2021;69(1):33-40. |
R827039 (2002) |
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Landrigan PJ, Suk WA, Amler RW. Chemical wastes, children's health, and the Superfund Basic Research Program. Environmental Health Perspectives 1999;107(6):423-427. |
R827039 (2002) |
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Landrigan PJ, Claudio L, Markowitz SB, Berkowitz GS, Brenner BL, Romero H, Wetmur JG, Matte TD, Gore AC, Godbold JH, Wolff MS. Pesticides and inner-city children:exposures, risks, and prevention. Environmental Health Perspectives 1999;107(Supplement 3):431-437. |
R827039 (2002) R827039C002 (2002) R827039C003 (2000) |
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Landrigan PJ. Pediatric lead poisoning: is there a threshold? (Commentary). Public Health Reports 2000;115(6):530-531. |
R827039 (2002) |
not available |
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Landrigan PJ. Children's environmental health. Lessons from the past and prospects for the future. Pediatric Clinics of North America 2001;48(5):1319-1330. |
R827039 (2002) |
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Landrigan PJ, Schechter CB, Lipton JM, Fahs MC, Schwartz J. Environmental pollutants and disease in American children: estimates of morbidity, mortality, and costs for lead poisoning, asthma, cancer, and developmental disabilities. Environmental Health Perspectives 2002;110(7):721-728. |
R827039 (2002) |
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Landrigan PJ, Sonawane B, Mattison D, McCally M, Garg A. Chemical contaminants in breast milk and their impacts on children’s health: an overview. Environmental Health Perspectives 2002;110(6):A313-A315. |
R827039 (2002) |
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Landrigan PJ, Garg A. Chronic effects of toxic environmental exposures on children's health. Clinical Toxicology 2002;40(4):449-459. |
R827039 (2002) |
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Landrigan PJ. The worldwide problem of lead in petrol. (Editorial). Bulletin of the World Health Organization 2002;80(10):768. |
R827039 (2002) |
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Landrigan P. Pesticides and polychlorinated biphenyls (PCBs):an analysis of the evidence that they impair children’s neurobehavioral development. Molecular Genetics and Metabolism 2001;73(1):11-17. |
R827039 (2002) |
not available |
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Petrick L, Wolff M, Barupal D, Teitelbaum S. Comparison of untargeted and targeted perfluoroalkyl acids measured in adolescent girls. Chemosphere 01;290(133303). |
R827039 (2002) R831711 (Final) |
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Salama J, Chakraborty TR, Ng L, Gore AC. Effects of polychlorinated biphenyls on estrogen receptor-β expression in the anteroventral periventricular nucleus. Environmental Health Perspectives 2003;111(10):1278-1282. |
R827039C002 (2002) R831711 (2005) R831711 (2006) R831711 (2007) R831711 (Final) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Savitz DA, Ananth CV, Berkowitz GS, Lapinski R. Concordance among measures of pregnancy outcome based on fetal size and duration of gestation. American Journal of Epidemiology 2000;151(6):627-633. |
R827039 (2002) |
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Susser EB, Brown A, Matte TD. Prenatal factors and adult mental and physical health. Canadian Journal of Psychiatry 1999;44(4):326-334. |
R827039 (2002) |
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Susser E, Matte TD. Early antecedents of adult health. Journal of Urban Health 1998;75(2):236-241. |
R827039 (2002) |
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Susser E, Terry MB, Matte T. The birth cohorts grow up: new opportunities for epidemiology. Paediatric and Perinatal Epidemiology 2000;14(2):98-100. |
R827039 (2002) |
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Weiss B, Landrigan P. The developing brain and the environment: an introduction. Environmental Health Perspectives 2000;108(Supplement 3):373-374. |
R827039 (2002) |
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Wolff MS, Landrigan PJ. Organochlorine chemicals and children’s health (editorial). Journal of Pediatrics 2002;140(1):10-13. |
R827039 (2002) |
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Supplemental Keywords:
RFA, Scientific Discipline, Health, Toxics, Epidemiology, pesticides, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Children's Health, genetic susceptability, environmental health, pesticide exposure, urban air, developmental neurotoxicity, health risks, lead, respiratory problems, PCBs, environmental risks, airway disease, developmental lead exposure, neurotoxicity, children, Human Health Risk Assessment, childhood lead exposure, neurodevelopmental toxicity, susceptibility, human exposure, assessment of exposure, childhood respiratory disease, children's vulnerablity, lead exposure, environmentally caused disease, children's environmental health, growth & development, age dependent response, human health riskProgress and Final Reports:
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827039C001 Growing Up Healthy in East Harlem
R827039C002 Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children
R827039C003 Genetics of Chlorpyrifos Risk in Minority Populations
R827039C004 Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood
R827039C005 Neuroendocrine Mechanisms of Environmental Toxicants: PCBs and Pesticides
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.