Grantee Research Project Results

Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children

EPA Grant Number: R827039C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R827039
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Research on Early Childhood Exposure and Development in Puerto Rico
Center Director: Alshawabkeh, Akram
Title: Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children
Investigators: Berkowitz, Gertrud S. , Wolff, Mary S. , Matte, Thomas
Institution: Mount Sinai School of Medicine
EPA Project Officer: Callan, Richard
Project Period: August 1, 1998 through July 31, 2003 (Extended to July 31, 2004)
Project Amount: Refer to main center abstract for funding details.
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health

Objective:

Two epidemiologic research projects seek to determine whether pesticides and PCBs have adverse effects on the neurological development of children in the inner city and whether these effects are still evident in adult life. The first of two epidemiologic investigations, closely linked to the Prevention Research Project, is a prospective study of neurodevelopment and health outcomes in relation to antenatal exposures to PCB, chlorpyrifos and other environmental toxicants as well as diet in an ethnically diverse birth cohort of New York City infants delivered at Mount Sinai Hospital. The second epidemiologic investigation is a retrospective cohort study of the relationship between prenatal exposure to polychlorinated biphenyl (PCBs) and neurodevelopmental outcomes in adolescence and adulthood. It will be undertaken in 162 young African American men, now in their 20's and 30's, who have been followed through childhood and adolescence. Their cognitive ability and other domains of neuropsychological status will be re-evaluated in this project. Pre-natal maternal serum samples have been safely stored and will be used to assess pre-natal PCB exposure.

Publications and Presentations:

Publications have been submitted on this subproject: View all 8 publications for this subproject | View all 41 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 5 journal articles for this subproject | View all 33 journal articles for this center

Supplemental Keywords:

children, exposure, pesticides, PCBs, neurological,, Health, RFA, Scientific Discipline, Susceptibility/Sensitive Population/Genetic Susceptibility, Health Risk Assessment, Risk Assessments, genetic susceptability, Environmental Chemistry, Endocrine Disruptors - Human Health, Environmental Microbiology, Children's Health, endocrine disruptors, Biochemistry, Endocrine Disruptors - Environmental Exposure & Risk, health effects, Human Health Risk Assessment, sensitive populations, environmental hazard exposures, harmful environmental agents, reproductive development, neurodevelopmental toxicity, growth & development, human exposure, biological response, neurotoxicity, children, endocrine disrupting chemicals, toxics, environmentally caused disease, environmental health hazard, neurodevelopmental, PCBs, assessment of exposure, human susceptibility, developmental disorders

Progress and Final Reports:

Main Center Abstract and Reports:

R827039 Center for Research on Early Childhood Exposure and Development in Puerto Rico

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827039C001 Growing Up Healthy in East Harlem
R827039C002 Exposure to Indoor Pesticides and PCBs and their Effects on Growth and Neurodevelopment in Urban Children
R827039C003 Genetics of Chlorpyrifos Risk in Minority Populations
R827039C004 Prenatal PCB Exposure and Neurodevelopmental Outcomes in Adolescence and Adulthood
R827039C005 Neuroendocrine Mechanisms of Environmental Toxicants: PCBs and Pesticides

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.