Grantee Research Project Results
2003 Progress Report: Study of Phthalates in Pregnant Woman and Children
EPA Grant Number: R829436Title: Study of Phthalates in Pregnant Woman and Children
Investigators: Swan, Shanna Helen , Redmon, J. Bruce , Lasley, Bill L. , Sparks, Amy , Calafat, Antonia , Wang, Christina , Drobnis, Erma
Current Investigators: Swan, Shanna Helen , Lasley, Bill L. , Sparks, Amy , Calafat, Antonia , Redmon, Bruce , Wang, Christina , Kruse, Robin
Institution: University of Missouri - Columbia , University of Iowa , Centers for Disease Control and Prevention , University of Minnesota , University of California - Davis
Current Institution: University of Rochester , Centers for Disease Control and Prevention , Harbor-UCLA Medical Center , University of California - Davis , University of Iowa , University of Minnesota , University of Missouri - Columbia
EPA Project Officer: Aja, Hayley
Project Period: August 1, 2001 through January 31, 2005 (Extended to July 31, 2007)
Project Period Covered by this Report: August 1, 2002 through January 31, 2003
Project Amount: $2,779,164
RFA: Endocrine Disruptors: Epidemiologic Approaches (2001) RFA Text | Recipients Lists
Research Category: Endocrine Disruptors , Environmental Justice , Human Health , Safer Chemicals
Objective:
The overall objective of this research project is to assess the risks posed by environmental phthalate levels to reproductive health. The research will address the following questions:
- Does in utero phthalate exposure alter breast and genital development?
- How do infants’ pre- and postnatal sensitivity to phthalates compare?
- What are the major sources of phthalate exposure for pregnant women and infants?
- Do phthalate metabolite levels vary with ethnicity and geography?
- Do genital and breast measurements vary with ethnicity and geography?
- How is phthalate metabolism altered by pregnancy?
Progress Summary:
By September 30, 2003, we had recruited 364 mothers and their babies (359 singletons and 10 pairs of twins). We also had conducted a total of 399 baby exams (354 first exams, 45 second exams), and collected 334 baby urine samples (at first exam) and 360 maternal urine samples. In addition, we developed databases and conducted statistical analyses on the first 200 mother-child pairs.
Future Activities:
During Year 3 of the project, we will:
- continue baby exams (expect N = 150 Year 3),
- obtain urine phthalate measurements on the first 200 mother-child pairs,
- obtain hormone levels on babies examined by 12 months as of March 1, 2004 (N = 111),
- complete database entry and cleaning for baby exams and mothers’ questionnaires for the first 400 subjects,
- and complete a paper on the reliability and feasibility of infant genital and breast exams.
Journal Articles:
No journal articles submitted with this report: View all 41 publications for this projectSupplemental Keywords:
phthalates, prenatal exposure, sexual development, geography, endocrine, endocrine disruptors, epidemiology, ethnicity, infants, neonates, health, biochemistry, chemistry, environmental exposure and risk, human health, health risk assessment, risk assessments, susceptibility, sensitive population, genetic susceptibility, childhood development, children, developmental biology, developmental effects, endocrine disrupting chemicals, epidemiologic studies, exposure, exposure studies, human growth and development, infants, metabolites, pregnancy, pregnant women, reproductive health,, Health, RFA, Scientific Discipline, Susceptibility/Sensitive Population/Genetic Susceptibility, Health Risk Assessment, Risk Assessments, Chemistry, genetic susceptability, Epidemiology, Endocrine Disruptors - Human Health, endocrine disruptors, Biochemistry, Endocrine Disruptors - Environmental Exposure & Risk, infants, pregnancy, developmental biology, human growth and development, prenatal exposure, exposure studies, pregnant women, endocrine disrupting chemicals, children, developmental effects, endocrine disruption, exposure, epidemiologic studies, metabolites, sexual development, reproductive health, childhood developmentRelevant Websites:
http://www.missouri.edu/~sff Exit
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.