Grantee Research Project Results

2002 Progress Report: Study of Phthalates in Pregnant Woman and Children

EPA Grant Number: R829436
Title: Study of Phthalates in Pregnant Woman and Children
Investigators: Swan, Shanna Helen , Lasley, Bill L. , Sparks, Amy , Calafat, Antonia , Redmon, Bruce , Wang, Christina , Drobnis, Erma
Current Investigators: Swan, Shanna Helen , Lasley, Bill L. , Sparks, Amy , Calafat, Antonia , Redmon, Bruce , Wang, Christina , Kruse, Robin
Institution: University of Missouri - Columbia , University of California - Los Angeles , University of Minnesota , University of California - Davis , University of Iowa
Current Institution: University of Rochester , Centers for Disease Control and Prevention , Harbor-UCLA Medical Center , University of California - Davis , University of Iowa , University of Minnesota , University of Missouri - Columbia
EPA Project Officer: Aja, Hayley
Project Period: August 1, 2001 through January 31, 2005 (Extended to July 31, 2007)
Project Period Covered by this Report: August 1, 2001 through January 31, 2002
Project Amount: $2,779,164
RFA: Endocrine Disruptors: Epidemiologic Approaches (2001) RFA Text | Recipients Lists
Research Category: Endocrine Disruptors , Environmental Justice , Human Health , Safer Chemicals

Objective:

The objective of this research project is to assess the risks posed by environmental phthalate levels to reproductive health by addressing the following issues:

· Does in utero phthalate exposure alter breast and genital development?
· How do infants' pre- and postnatal sensitivity to phthalates compare?
· What are major sources of phthalate exposure for pregnant women and infants?
· Do phthalate metabolite levels vary with ethnicity and geography?
· Do genital and breast measurements vary with ethnicity and geography?
· How is phthalate metabolism altered by pregnancy?

Progress Summary:

During Year 1 of the project, we: (1) piloted all phases of the study; (2) developed all study instruments, protocols, and databases; and (3) examined 94 subjects as of September 28, 2002.

Future Activities:

During Year 2 of the project, we expect to: (1) conduct 275 first visits (in California, Missouri, Minnesota, and Iowa); (2) conduct 125 second visits (in California, Missouri, and Minnesota); (3) use intensive tracing methods to locate subjects that have not responded to telephone calls and initial mailings; (4) begin urinary assays for follicle stimulating hormone; (5) complete at least one manuscript on methods used for physical exam; and (6) obtain descriptive statistics on genital and breast measurements in first 300 subjects, overall and stratified by ethnicity and center.

Journal Articles:

No journal articles submitted with this report: View all 41 publications for this project

Supplemental Keywords:

phthalates, prenatal exposure, sexual development, geography, ethnicity., Health, RFA, Scientific Discipline, Susceptibility/Sensitive Population/Genetic Susceptibility, Health Risk Assessment, Risk Assessments, Chemistry, genetic susceptability, Epidemiology, Endocrine Disruptors - Human Health, endocrine disruptors, Biochemistry, Endocrine Disruptors - Environmental Exposure & Risk, infants, pregnancy, developmental biology, human growth and development, prenatal exposure, exposure studies, pregnant women, endocrine disrupting chemicals, children, developmental effects, endocrine disruption, exposure, epidemiologic studies, metabolites, sexual development, reproductive health, childhood development

Relevant Websites:

http://www.missouri.edu/~sff Exit

Progress and Final Reports:

Original Abstract

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.