Grantee Research Project Results

2002 Progress Report: Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures

EPA Grant Number: R827353C010
Subproject: this is subproject number 010 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Health Effects Institute (2015 - 2020)
Center Director: Greenbaum, Daniel S.
Title: Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
Investigators: Speizer, Frank E.
Current Investigators: Speizer, Frank E. , Park, S.
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2001 through May 31, 2002
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Particulate Matter , Air Quality and Air Toxics , Air

Objective:

The main objective of this research project is to investigate associations of selected inflammatory and blood clotting parameters in free living humans with particle and criteria gas exposures.

Progress Summary:

This project is in collaboration with the Boston Veterans Hospital who currently is conducting the Normative Aging Study (NAS). During the first 3 years the VA Hospital has been collecting data. Measurements of approximately 650 individuals out of 1,200 participants have been completed. Statistical analysis, relationships to ambient pollution levels, and geographical relationships have just commenced. A plan for the data analysis was presented during the 2003 Scientific Advisory Committee meeting last March.

A new panel study was conducted last year in St. Louis, MO. Forty-four elderly individuals from four senior independent living facilities were enrolled for participation in the study. To evaluate the effect of traffic-related air pollution on cardiovascular health, individuals participated in a series of four separate day-trips from their suburban residences to activities in downtown St. Louis. Each day trip included two one-hour bus rides on a shuttle bus. In order to characterize gaseous and particulate exposures before, during, and after the bus trips, a number of continuous samplers were employed. These samplers were installed on two roll-around carts and in the rear of the shuttle bus. Continuous measurements of cardiac function were also collected during each day of participation using Holter monitors. In addition, samples of exhaled nitric oxide, blood pressure, blood oxygen, and blood samples were collected from participants before and after the trips. All data have been processed and data analysis has just begun.

References:

Lippman M, Frampton M, Schwartz J, Dockery DW, Schlesinger R, Koutrakis P, Froines J. The EPA's Particulate Matter (PM) Health Effects Research Centers Program: a mid-course (2 1/2 year) report of status, progress, and plans. Environmental Health Perspectives (in press, 2003).

Future Activities:

We will complete the data analysis and prepare manuscripts for publication.

Journal Articles:

No journal articles submitted with this report: View all 6 publications for this subproject

Supplemental Keywords:

air pollution, air pollutants, particulates, particulate matter, PM, fine particulates, PM2.5, blood viscosity, clotting parameters, heart rate, heart rate variability, criteria gas exposure, PM exposure, health effects, ambient pollution, ambient particles, Boston, Massachusetts, MA, St. Louis, Missouri, MO, elderly, susceptible populations, cardiac function, exhaled nitric oxide, blood pressure, blood oxygen., Health, RFA, Air, Scientific Discipline, Geographic Area, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessments, State, particulate matter, Biology, Environmental Chemistry, Epidemiology, Molecular Biology/Genetics, Atmospheric Sciences, Disease & Cumulative Effects, Toxicology, air toxics, Environmental Engineering, Environmental Monitoring, air quality, health effects, health risks, Human Health Risk Assessment, indoor air quality, inhaled, sensitive populations, human health, epidemelogy, respiratory disease, cardiac ischemia, particle size, pulmonary disease, cardiac arrhythmia, particle chemical composition, biological mechanism , elderly, human exposure, respiratory, risk assessment, ambient air monitoring, lung cancer, automotive emissions, gaseous co-polutants, blood viscosity, cardiopulmonary responses, chronic effects, dosimetry, monitoring, pulmonary, genetic susceptibility, particulate exposure, chemical exposure, children, exposure, particulates, PM, developmental effects, cardiopulmonery responses, ambient particle health effects, air pollutants, ambient air, inhaled particles, molecular epidemiology, toxics, inhalation toxicology, heart rate, atmospheric particulate matter, air pollution, ambient air quality, cardiopulmonary, cardiovascular disease, human health effects, human health risk, metals, human susceptibility, traffic related air pollution, ambient measurement methods, cardiopulmonary response, inhalation, interindividual variability, Massachusetts (MA), particle exposure

Relevant Websites:

http://www.hsph.harvard.edu/epacenter/ Exit

Progress and Final Reports:

Original Abstract

Main Center Abstract and Reports:

R827353 Health Effects Institute (2015 - 2020)

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core

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