Grantee Research Project Results

2004 Progress Report: Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia

EPA Grant Number: R827353C008
Subproject: this is subproject number 008 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Health Effects Institute (2015 - 2020)
Center Director: Greenbaum, Daniel S.
Title: Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
Investigators: Godleski, John J.
Current Investigators: Godleski, John J. , Gonzalez-Flecha, Beatriz , Wellenius, Gregory
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2004 through May 31, 2005
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Particulate Matter , Air Quality and Air Toxics , Air

Objective:

The main aim of this project is to investigate the effects of concomitant gaseous co-pollutants, particle size, and particle composition.

Progress Summary:

Effects of Ambient Particles and Gas Mixtures (Exposures to CAPs With O₃) on the Rat Model of Myocardial Infarction

We have compared the effects of the following exposures: filtered air, CAPs alone, ozone alone, and CAPs plus ozone. CAPs exposure levels will be approximately 30 times the ambient level. Ozone exposures started at 120 ppb, comparable to the current ambient 1-hour standard, and at a level where effects might be expected. Because of the extensive efforts required for subproject R827353C011, we have not yet completed the full range of studies planned for this project. Additional CAPs-ozone exposure tests were conducted in October 2005. Preliminary findings (not including the October 2005 tests) are very encouraging, suggesting significant increases in both ventricular premature beats and supraventricular premature beats in rats exposed to ozone alone, none with sham exposures, non-significant increases with CAPs alone, but with exposures to the combination of CAPs and Ozone a markedly significant increase in both types of arrhythmias is observed.

Journal Articles:

No journal articles submitted with this report: View all 4 publications for this subproject

Supplemental Keywords:

exposure, health effects, susceptibility, metals, public policy, biology, engineering, epidemiology, toxicology, environmental chemistry, monitoring, air pollutants, air pollution, air quality, ambient air, ambient air monitoring, ambient air quality, ambient measurement methods, ambient monitoring, ambient particle health effects, ambient particles, animal inhalation study, assessment of exposure, biological mechanism, biological response, cardiopulmonary, cardiopulmonary response, cardiovascular disease, chemical exposure, children, developmental effects, dosimetry, environmental health hazard, exposure and effects, genetic susceptibility, health risks, human exposure, human health, human health effects, human health risk, human susceptibility, indoor air quality, indoor exposure, inhalation, inhalation toxicology, inhaled particles, lead, measurement methods, particle exposure, particulate exposure, particulates, pulmonary, pulmonary disease, respiratory, respiratory disease, risk assessment, sensitive populations, stratospheric ozone,, RFA, Health, Air, Scientific Discipline, Geographic Area, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessments, State, particulate matter, Biology, genetic susceptability, Environmental Chemistry, Epidemiology, tropospheric ozone, Microbiology, Environmental Microbiology, Molecular Biology/Genetics, Children's Health, Atmospheric Sciences, Disease & Cumulative Effects, Toxicology, air toxics, Environmental Engineering, Environmental Monitoring, epidemelogy, respiratory disease, air quality, health risks, Human Health Risk Assessment, epidemeology, indoor air quality, sensitive populations, health effects, cardiac ischemia, human health, inhaled, biological mechanism , pulmonary disease, particle size, particle chemical composition, ambient monitoring, stratospheric ozone, co-pollutants, ambient air monitoring, elderly, indoor exposure, biological response, respiratory, risk assessment, lung cancer, Washington (WA), gaseous co-polutants, human exposure, genetic susceptibility, chemical exposure, chronic effects, particulate exposure, cardiopulmonary responses, dosimetry, susceptibility, pulmonary, lung, monitoring, children, developmental effects, ambient particle health effects, exposure, particulates, toxics, inhalation toxicology, inhaled particles, molecular epidemiology, environmental health hazard, indoor air, Illinois (IL), Minnesota, ambient air, air pollutants, air pollution, cardiovascular disease, human health risk, assessment of exposure, ambient air quality, human health effects, human susceptibility, Connecticut (CT), cardiopulmonary, PM 2.5, particle exposure, cardiopulmonary response, interindividual variability, inhalation, ambient measurement methods, Massachusetts (MA), Utah (UT)

Progress and Final Reports:

Original Abstract

Main Center Abstract and Reports:

R827353 Health Effects Institute (2015 - 2020)

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core

Top of Page

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.