Grantee Research Project Results
2022 Progress Report: Innovative methodology based on a non-targeted screening approach combined with activity patterns for estimation of soil and dust ingestion rate in children.
EPA Grant Number: R840199Title: Innovative methodology based on a non-targeted screening approach combined with activity patterns for estimation of soil and dust ingestion rate in children.
Investigators: Quinete, Natalia , Gardinali, Piero , Bagner, Daniel , George, Florence
Institution: Florida International University
EPA Project Officer: Hahn, Intaek
Project Period: June 1, 2021 through May 6, 2025
Project Period Covered by this Report: August 1, 2022 through August 1,2023
Project Amount: $1,217,193
RFA: Estimating Childrens Soil and Dust Ingestion Rates for Exposure Science (2020) RFA Text | Recipients Lists
Research Category: Children's Health , Endocrine Disruptors , Human Health
Objective:
The specific objectives are:
Aim 1: Development of a non-targeted screening approach to estimate soil and dust ingestion by children.
Aim 2: Activity pattern study to estimate soil and dust ingestion by children.
Aim 3: Statistical calculations combining both approaches for accurate estimation of soil and dust ingestion rate by children.
Progress Summary:
- Two post-doctoral research associates had left FIU for permanent jobs in the government and industry beginning of January 2023.
- A graduate student in the research group was trained and started working on January 2023 in the project processing the water and urine samples.
- A postdoc was hired and started working in February 2023 and is working on processing food, soil, and dust samples.
- A graduate student has started working in the project in support of Objective 2 and 3, performing statistical analysis.
- A total of 7 undergraduate students were trained to help with family recruitment as well as with chemical analysis.
- All personnel went through CITI IRB training and safety training to work in recruitment and the lab and amendments were done to the initial Institutional Review Board (IRB) approved on 10 October 2021 to account for changes of personnel involved in the project.
- We have recruited a total of 70 children to participate in the project, while we didn’t reach out the targeted enrollment goal of 81, we recruited enough participants to answer the research questions proposed in the project.
- Surveys and questionnaires performed in REDCap were administered online and through the phone.
- A total of 14 children/families have completed the first year of sample collection (N=253 samples) and surveys (N=14) and 28 families have already completed the first two sample sets Q1 and Q2 (N=344 samples) and surveys (N=18).
- Non-targeted screening methods for different matrices (urine, soil, dust, food, and water) were validated in terms of performance and a total of 597samples were received to date, 483 samples were processed and analyzed by LC-Orbitrap MS and a total of 434 samples were further processed by Compound Discoverer for identification of chemicals of concern.
- Specific and unique chemical tracers were identified in dust and soil.
Future Activities:
- Continue efforts for sampling soil, dust, water, food, and urine samples and completing surveys from participants until July 2024
- Continue processing and analyzing samples to elucidate children’s chemical exposure and develop semi-quantification approaches to quantify soil and dust tracers in the samples.
- Calculation of soil and dust ingestion rate by children from identified chemical tracers in dust and soil.
- Statistical analysis to apply activity pattern data to estimate dust and soil ingestion rate.
- Statistical analysis to evaluate correlations between estimated soil and dust ingestion rate and socioeconomic status, child age, region, and children behavior.
Journal Articles on this Report : 1 Displayed | Download in RIS Format
| Other project views: | All 1 publications | 1 publications in selected types | All 1 journal articles |
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Ogunbiyi O, Cappelini L, Mejhias E, George F, Gardinali P, Bagner D. Innovative non-targeted screening approach using High-resolution mass spectrometry for the screening of organic chemicals and identification of specific tracers of soil and dust exposure in children. JOURNAL OF HAZARDOUS MATERIALS 2024;469(134025) |
R840199 (2022) R840199 (2023) |
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Supplemental Keywords:
NTA, drinking water, food, urine, soil, dust, Florida, underrepresented population, SHEDS-HT, environmental exposureRelevant Websites:
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.