Grantee Research Project Results

2021 Progress Report: PFAS UNITED: Poly - and Perfluoroalkyl Substances - U.S.National Investigation of Transport & Exposure from Drinking Water and Diet

EPA Grant Number: R839482
Title: PFAS UNITED: Poly - and Perfluoroalkyl Substances - U.S.National Investigation of Transport & Exposure from Drinking Water and Diet
Investigators: Higgins, Christopher , Illangasekare, Tissa , Adgate, John L. , Stapleton, Heather , Knappe, Detlef , Hoppin, Jane , Carignan, Courtney , Duckorth, Owen , Choyke, Sarah , Brown, Juliane , Stults, John , Barton, Kelsey , Bhattacharya, Ankita , Bauer, Rachel , Guo, Ying , Li, Allen , Meng, Pingping , Doydora, Sarah , Zhang, Chuhui , Holden, Kate , Hoxie, Taylor
Current Investigators: Higgins, Christopher , Illangasekare, Tissa , Adgate, John L. , Stapleton, Heather , Knappe, Detlef , Hoppin, Jane , Carignan, Courtney
Institution: Colorado School of Mines , Duke University , Michigan State University , University of Colorado at Denver , North Carolina State University
EPA Project Officer: Packard, Benjamin H
Project Period: May 1, 2019 through April 30, 2022 (Extended to March 31, 2024)
Project Period Covered by this Report: May 1, 2021 through April 30,2022
Project Amount: $1,964,375
RFA: National Priorities: Per- and Polyfluoroalkyl Substances (2018) RFA Text | Recipients Lists
Research Category: Ecological Indicators/Assessment/Restoration , Climate Change , Water , Water Quality

Objective:

The goal of this study is to develop a comprehensive set of data related to the fate, transport, and bioaccumulation of poly- and perfluoroalkyl substances (PFASs) and resultant human exposure. This study seeks to fill the data gaps on the fundamental environmental behavior of overlooked PFASs, the uptake into local food sources in impacted communities, and the relevance of that uptake for human exposure to PFASs.

Progress Summary:

As of the three-year mark, we have held one in-person team meeting with all collaborating institutions and three virtual introductory Advisory Board meetings. Thus far in the research we have successfully achieved the following:

Completed range-finding, kinetic, and preliminary studies for PFAS isotherm experiments
Completed method development for the determination of perfluoroalkyl ether acids (PFEAs) and other PFASs in plant products and analyzed field samples collected in North Carolina
Finished PFAS plant uptake greenhouse experiments and completed preliminary extraction and analysis.
Completed method development for the detection and quantification of PFASs in honey, meat and egg samples and analyzed samples collected in Michigan.
Finished collection of blood, wristband, and samples from participants in Michigan
Ran additional statistical analyses of Colorado and North Carolina PFAS serum datasets

Future Activities:

Complete analysis and submit results of sorption studies for publication
Submit results of unsaturated transport experiments for publication
Complete analysis of greenhouse experiments and submit for publication
Submit results of TSCF experiments for publication
Complete analysis of market basket samples and submit for publication
Complete analysis of human biomonitoring samples and submit for publication
Summarize and report-back results to participants and community members in Michigan

Journal Articles on this Report : 4 Displayed | Download in RIS Format

Publications Views
Other project views:	All 19 publications	10 publications in selected types	All 10 journal articles

Publications
Type	Citation	Project	Document Sources
Journal Article	Herkert NJ, Kassotis CD, Zhang S, Han Y, Pulikkal VF, Sun M, Ferguson PL, Stapleton HM. Characterization of per-and polyfluorinated alkyl substances present in commercial anti-fog products and their in vitro adipogenic activity. Environmental Science & TechnologyM 2022;56(2):1162-73.	R839482 (2021)	Abstract from PubMed Full-text: ACS Publications - Full Text HTML Exit Abstract: Pubmed Abstract- HTML Other: ACS Publications - Full Text PDF Exit
Journal Article	Herkert NJ, Kassotis CD, Zhang S, Han Y, Pulikkal VF, Sun M, Ferguson PL, Stapleton HM. Characterization of per-and polyfluorinated alkyl substances present in commercial anti-fog products and their in vitro adipogenic activity. Environmental Science & Technology 2022;56(2):1162-73.	R839482 (2021) R839482 (2022)	Full-text: ACS Full Text HTML Exit Abstract: Pubmed Abstract- HTML
Journal Article	Meng P, DeStefano NJ, Knappe DR. Extraction and Matrix Cleanup Method for Analyzing Novel Per-and Polyfluoroalkyl Ether Acids and Other Per-and Polyfluoroalkyl Substances in Fruits and Vegetables. Journal of Agricultural and Food Chemistry 2022;70(16):4792-804.	R839482 (2021)	Full-text: ACS Full Text- HTML Exit Abstract: PubMed Abstract- HTML
Journal Article	Zhang C, McElroy AC, Liberatore HK, Alexander NL, Knappe DR. Stability of Per-and Polyfluoroalkyl Substances in Solvents Relevant to Environmental and Toxicological Analysis. Environmental Science & Technology. 2021 Nov 4.	R839482 (2021)	Full-text: ACS Full Text- HTML Exit Abstract: Pubmed Abstract - HTML

Supplemental Keywords:

PFAS, drinking water, food, contaminants, exposure

Relevant Websites:

PFAS Unitedd Exit

Progress and Final Reports:

Original Abstract

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.