Grantee Research Project Results
Publications submitted after final report Details for Grant Number R835737
Human Models for Analysis of Pathways (H MAPs) Center
RFA:
Organotypic Culture Models for Predictive Toxicology Center (2013)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year (Date Added to Report) | Document Sources |
|---|---|---|---|---|---|---|
| Abstract | Time-lapse microscopy of oxidative stress demonstrates metabolic sensitivity of retinal pericytes under high glucose condition. | JOURNAL OF BIOPHOTONICS | Ghanian Z, Mehvar S, Jamali N, Sheibani N, Ranji M | Ghanian Z, Mehvar S, Jamali N, Sheibani N, Ranji M. Time-lapse microscopy of oxidative stress demonstrates metabolic sensitivity of retinal pericytes under high glucose condition. JOURNAL OF BIOPHOTONICS 2018;11(9):e201700289 |
R835737 (Final) (07/25/23) |
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| Abstract | Exclusive Liquid Repellency: An Open Multi-Liquid-Phase Technology for Rare Cell Culture and Single-Cell Processing. | APPLIED MATERIALS & INTERFACES | Li C, Yu J, Schehr J, Berry S, Leal T, Lang J, Beebe D | Li C, Yu J, Schehr J, Berry S, Leal T, Lang J, Beebe D. Exclusive Liquid Repellency: An Open Multi-Liquid-Phase Technology for Rare Cell Culture and Single-Cell Processing. APPLIED MATERIALS & INTERFACES 2018;10(20):17065-17070 |
R835737 (Final) (07/25/23) |
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| Abstract | Double-exclusive liquid repellency (double-ELR): an enabling technology for rare phenotype analysis. | LAB ON A CHIP | Li C, Yu J, Paine P, Juang D, Berry S, Beebe D | Li C, Yu J, Paine P, Juang D, Berry S, Beebe D. Double-exclusive liquid repellency (double-ELR): an enabling technology for rare phenotype analysis. LAB ON A CHIP 2018;18(18):2710-2719 |
R835737 (Final) (07/25/23) |
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| Abstract | Hydrogel Arrays and Choroidal Neovascularization Models for Evaluation of Angiogenic Activity of Vital Pulp Therapy Biomaterials. | JOURNAL OF ENDODONTICS | Saghiri M, Asatourian A, Nguyn E, Wang S, Sheibani N | Saghiri M, Asatourian A, Nguyn E, Wang S, Sheibani N. Hydrogel Arrays and Choroidal Neovascularization Models for Evaluation of Angiogenic Activity of Vital Pulp Therapy Biomaterials. JOURNAL OF ENDODONTICS 2018;44(5):773-779 |
R835737 (Final) (07/25/23) |
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| Journal Article | Synthetic alternatives to Matrigel | NATURE REVIEWS MATERIALS | Aisenbrey E, Murphy W | Aisenbrey E, Murphy W. Synthetic alternatives to Matrigel. Nature Reviews Materials 2020 |
R835737 (Final) (06/18/20) |
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| Journal Article | A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction | DEVELOPMENTAL BIOLOGHY, STEM CELLS AND REGENERATIVE MEDICINE | Bakooshli M, Lippmann E, Mulcahy B, Iyer N, Nguyen C, Tung K, Stewart B, van den Dorpel H, Fuehrmann T, Gilbert P, Shoichet M, Bigot A, Pegoraro E, Ahn H, Ginsberg H, Zhen M, Ashton R, Gilbert P | Bakooshli M, Lippmann E, Mulcahy B, Iyer N, Nguyen C, Tung K, Stewart B, van den Dorpel H, Fuehrmann T, Gilbert P, Shoichet M, Bigot A, Pegoraro E, Ahn H, Ginsberg H, Zhen M, Ashton R, Gilbert P. A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction. DEVELOPMENTAL BIOLOGHY, STEM CELLS AND REGENERATIVE MEDICINE 2019;8(e44530) |
R835737 (Final) (07/25/23) |
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| Journal Article | Microparticles locally deliver active interleukin-1 receptor antagonist in vivo. | None | Clements AE, Groves ER, Chamberlain CS, Vanderby R, Murphy WL | Clements AE, Groves ER, Chamberlain CS, Vanderby R, Murphy WL. Microparticles locally deliver active interleukin-1 receptor antagonist in vivo. Advanced Healthcare Materials 2018;7(16):1800263. |
R835737 (Final) (07/25/23) |
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| Journal Article | Single-injection ex ovo transplantation method for broad spinal cord engraftment of human pluripotent stem cell-derived motor neurons | JOURNAL OF NEUROSCIENCE METHODS | Estevez-Silva M, Sreeram A, Cuskey S, Fedorchak N, Layer N, Ashton R | Estevez-Silva M, Sreeram A, Cuskey S, Fedorchak N, Layer N, Ashton R. Single-injection ex ovo transplantation method for broad spinal cord engraftment of human pluripotent stem cell-derived motor neurons. JOURNAL OF NEUROSCIENCE METHODS 2018;298:16-23 |
R835737 (Final) (07/26/23) |
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| Journal Article | Cyp1b1-deficient retinal astrocytes are more proliferative and migratory and are protected from oxidative stress and inflammation. | AMERICAN JOURNAL OF PHYSIOLOGY | Falero-Perez J, Sorenson C, Sheibani N | Falero-Perez J, Sorenson C, Sheibani N. Cyp1b1-deficient retinal astrocytes are more proliferative and migratory and are protected from oxidative stress and inflammation. AMERICAN JOURNAL OF PHYSIOLOGY 2019;306(6):C767-C781 |
R835737 (Final) (07/26/23) |
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| Journal Article | Modular derivation of diverse, regionally discrete human posterior CNS neurons enables discovery of transcriptomic patterns | SCIENCE ADVANCES | Iyer N, Shin J, Cuskey S, Tian Y, Nicol N, Doersch T, Seipel F, McCalla S, Roy S, Ashton R | Iyer N, Shin J, Cuskey S, Tian Y, Nicol N, Doersch T, Seipel F, McCalla S, Roy S, Ashton R. Modular derivation of diverse, regionally discrete human posterior CNS neurons enables discovery of transcriptomic patterns. SCIENCE ADVANCES 2022;8(39):eabn7430 |
R835737 (Final) (01/13/23) |
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| Journal Article | A Microphysiological Approach to Evaluate Effectors of Intercellular Hedgehog Signaling in Development | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | Johnson B, VItek R, Morgan M, Fink D, Beames T, Geiger P, Beebe D, Lipinski R | Johnson B, VItek R, Morgan M, Fink D, Beames T, Geiger P, Beebe D, Lipinski R. A Microphysiological Approach to Evaluate Effectors of Intercellular Hedgehog Signaling in Development. Frontiers in Cell and Developmental Biology 2021;9:71. |
R835737 (Final) (03/25/21) |
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| Journal Article | Engineered Perineural Vascular Plexus for Modeling Developmental Toxicity | ADVANCED HEALCARE MATERIALS | Kauschik G, Gupta K, Harms V, Torr E, Evans J, Johnson H, Soref C, Acevedo-Acevedo S, Antosiewicz-Bourget J, Mamott D | Kauschik G, Gupta K, Harms V, Torr E, Evans J, Johnson H, Soref C, Acevedo-Acevedo S, Antosiewicz-Bourget J, Mamott D. Engineered Perineural Vascular Plexus for Modeling Developmental Toxicity. Advanced Healcare Materials 2020;(2000825). |
R835737 (Final) (07/17/20) |
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| Journal Article | Single-dose mRNA therapy via biomaterial-mediated sequestration of overexpressed proteins | SCIENCE ADVANCES | Khalil A, Yu X, Umhoefer J, Chamberlain C, COnnie S, Wildenauer L, Diarra G, Hacker T, Murphy W | Khalil A, Yu X, Umhoefer J, Chamberlain C, COnnie S, Wildenauer L, Diarra G, Hacker T, Murphy W. Single-dose mRNA therapy via biomaterial-mediated sequestration of overexpressed proteins. Science Advances 2020;6(27):eaba2422. |
R835737 (Final) (08/13/20) |
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| Journal Article | Engineering induction of singular neural rosette emergence within jPSC-derived tissues. | None | Knight GT, Lundin BF, Iyer N, Ashton LMT, Sethares WA, Willett RM, Ashton RS | Knight GT, Lundin BF, Iyer N, Ashton LMT, Sethares WA, Willett RM, Ashton RS. Engineering induction of singular neural rosette emergence within jPSC-derived tissues. eLIFE 2018;7:e37549 (23 pp.). |
R835737 (Final) (07/25/23) |
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| Journal Article | β2-adrenergic receptor antagonism attenuates CNV through inhibition of VEGF and IL-6 expression. | None | Lavine JA, Farnoodian M, Wang S, Darjatmoko SR, Wright LS, Gamm DM, Ip MS, Sorenson CM, Sheibani N | Lavine JA, Farnoodian M, Wang S, Darjatmoko SR, Wright LS, Gamm DM, Ip MS, Sorenson CM, Sheibani N. β2-adrenergic receptor antagonism attenuates CNV through inhibition of VEGF and IL-6 expression. Investigative Ophthalmology & Visual Science 2017;58(1):299-308. |
R835737 (Final) (07/25/23) |
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| Journal Article | Combination of Heparin Binding Peptide and Heparin Cell Surface Coatings for Mesenchymal Stem Cell Spheroid Assembly. | BIOCONJUGATE CHEMISTRY | Lei J, Murphy W, Temenoff J | Lei J, Murphy W, Temenoff J. Combination of Heparin Binding Peptide and Heparin Cell Surface Coatings for Mesenchymal Stem Cell Spheroid Assembly. BIOCONJUGATE CHEMISTRY 2018;29(4):878-884 |
R835737 (Final) (07/25/23) |
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| Journal Article | The effect of Tmem135 overexpression on the mouse heart. | PLOS ONE | Lewis S, Takimoto T, Mehrvar S, Higuchi H, Doebley A, Stokes G, Sheibani N, Ideda S, Ranji M, Ikeda A | Lewis S, Takimoto T, Mehrvar S, Higuchi H, Doebley A, Stokes G, Sheibani N, Ideda S, Ranji M, Ikeda A. The effect of Tmem135 overexpression on the mouse heart. PLOS ONE 2018;13(8):e0201986 |
R835737 (Final) (07/25/23) |
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| Journal Article | Social motility of biofilm-like microcolonies in a gliding bacterium | NATURE COMMUNICATIONS | Li C, Hurley A, Hu W, Warrick J, Lozano G, Ayuso J, Pan W, Handlesman J, Beebe D | Li C, Hurley A, Hu W, Warrick J, Lozano G, Ayuso J, Pan W, Handlesman J, Beebe D. Social motility of biofilm-like microcolonies in a gliding bacterium. Nature Communications 2021;12(1). |
R835737 (Final) (11/05/21) |
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| Journal Article | New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop | REGULATORY TOXICOLOGY AND PHARMACOLOGY | Mahony C, Ashton R, Birk B, Boobis A, Cull T, Datson G, Ewart L, Knudsen T, Manou I, Maurer-Stroh S | Mahony C, Ashton R, Birk B, Boobis A, Cull T, Datson G, Ewart L, Knudsen T, Manou I, Maurer-Stroh S. New ideas for non-animal approaches to predict repeated-dose systemic toxicity:Report from an EPAA Blue Sky Workshop. Regulatory Toxicology and Pharmacology 2020;114(UNSP 104668). |
R835737 (Final) (07/17/20) |
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| Journal Article | Human induced pluripotent stem cell-derived planar neural organoids assembled on synthetic hydrogels | None | Majumder J, Torr E, Aisenbrey E, Lebakken C, Favreau P, Richards W, Yin Y, Chang Q, Murphy W | Majumder J, Torr E, Aisenbrey E, Lebakken C, Favreau P, Richards W, Yin Y, Chang Q, Murphy W. Human induced pluripotent stem cell-derived planar neural organoids assembled on synthetic hydrogels. JOURNAL OF TISSUE ENGINEERING 2024;15(20417314241230633) |
R835737 (Final) (03/01/24) |
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| Journal Article | Intravitreal Delivery of VEGF-A(165)-loaded PLGA Microparticles Reduces Retinal Vaso-Obliteration in an In Vivo Mouse Model of Retinopathy of Prematurity. | CURRENT EYE RESEARCH | Mezu-Ndubuisi O, Wang Y, Schoephoerster J, Falero_Perez J, Zaitoun I, Sheibani, Gong S | Mezu-Ndubuisi O, Wang Y, Schoephoerster J, Falero_Perez J, Zaitoun I, Sheibani, Gong S. Intravitreal Delivery of VEGF-A(165)-loaded PLGA Microparticles Reduces Retinal Vaso-Obliteration in an In Vivo Mouse Model of Retinopathy of Prematurity. CURRENT EYE RESEARCH 2018;44(Full Text HTML):275-286 |
R835737 (Final) (07/25/23) |
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| Journal Article | Tracking and Predicting Human Somatic Cell Reprogramming Using Nuclear Characteristics | BIOPHYSICAL JOURNAL | Molugy K, Harkness T, Carlson-Tevermer J, Prestil R, Piscopo N, Seymour S, Knight G, Ashton R, Saha K | Molugy K, Harkness T, Carlson-Tevermer J, Prestil R, Piscopo N, Seymour S, Knight G, Ashton R, Saha K. Tracking and Predicting Human Somatic Cell Reprogramming Using Nuclear Characteristics. BIOPHYSICAL JOURNAL 2020;118(9):2086-2102. |
R835737 (Final) (05/26/20) |
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| Journal Article | Modeling chemical effects on breast cancer: the importance of the microenvironment in vitro | INTEGRATIVE BIOLOGY | Morgan M, Schuler L, Ciciliano J, Johnson B, Alarid E, Beebe D | Morgan M, Schuler L, Ciciliano J, Johnson B, Alarid E, Beebe D. Modeling chemical effects on breast cancer: the importance of the microenvironment in vitro. Integrative Biology 2020;12(2):21-33 |
R835737 (Final) (07/17/20) |
not available |
| Journal Article | Reproducibility across single-cell RNA-seq protocols for spatial ordering analysis | PLOS ONE | Seirup M, Chu L, Sengupta S, Leng N, Browder H, Kapadia K, Shafer C, Duffin B, Elwell A, Bolin J | Seirup M, Chu L, Sengupta S, Leng N, Browder H, Kapadia K, Shafer C, Duffin B, Elwell A, Bolin J. Reproducibility across single-cell RNA-seq protocols for spatial ordering analysis. PLOS One 2020;15(9). |
R835737 (Final) (11/05/20) |
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| Journal Article | Rapid changes in chromatin structure during dedifferentiation of primary hepatocytes in vitro | GENOMICS | Seirup M, Sengupta S, Swanson S, McIntosh B, Collins M, Cu L, Cheng Z, Gorkin D, Duffin B, Bolin J, Argus C, Stewart R, Thompson J | Seirup M, Sengupta S, Swanson S, McIntosh B, Collins M, Cu L, Cheng Z, Gorkin D, Duffin B, Bolin J, Argus C, Stewart R, Thompson J. Rapid changes in chromatin structure during dedifferentiation of primary hepatocytes in vitro. GENOMICS 2022;114(3):110330. |
R835737 (Final) (08/11/22) |
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| Journal Article | Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling | SCIENTIFIC REPORTS | Virumbrales-Munoz M, Ayuso J, Lacueva A, Randelovic T, Livingston M, Beebe D, Olivan S, Pereboom D, Doblare M, Fernandez L | Virumbrales-Munoz M, Ayuso J, Lacueva A, Randelovic T, Livingston M, Beebe D, Olivan S, Pereboom D, Doblare M, Fernandez L. Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling. Scientific Reports 2020;10(1):757. |
R835737 (Final) (08/13/20) |
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| Journal Article | Controlled aggregation enhances immunomodulatory potential of mesenchymal stromal cell aggregates | STEM CELLS TRANSLATIONAL MEDICINE | Xie A, Zacharias N, Binder B, Murphy W | Xie A, Zacharias N, Binder B, Murphy W. Controlled aggregation enhances immunomodulatory potential of mesenchymal stromal cell aggregates. Stem Cells Translational Medicine 2021;1(18). |
R835737 (Final) (04/21/21) |
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| Journal Article | Addition of mineral coated microparticles to soluble interleukin-1 receptor antagonist injected subcutaneously improves and extends systemic interleukin-1 inhibition. | None | Clements AE, Leiferman EM, Chamberlain CS, Vanderby R, Murphy WL | Clements AE, Leiferman EM, Chamberlain CS, Vanderby R, Murphy WL. Addition of mineral coated microparticles to soluble interleukin-1 receptor antagonist injected subcutaneously improves and extends systemic interleukin-1 inhibition. Advanced Therapeutics 2018;1(7):1800048. |
R835737 (Final) (07/25/23) |
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| Journal Article | Sustained release and protein stabilization reduce the growth factor dosage required for human pluripotent stem cell expansion. | None | Khalil AS, Xie AW, Johnson HJ, Murphy WL | Khalil AS, Xie AW, Johnson HJ, Murphy WL. Sustained release and protein stabilization reduce the growth factor dosage required for human pluripotent stem cell expansion. Biomaterials 2020:120007. |
R835737 (Final) (05/26/20) |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.