Grantee Research Project Results
Publications Details for Grant Number R834998
Model of Toxicant Response in Engineered Liver
RFA:
Computational Toxicology: Biologically-Based Multi-Scale Modeling (2010)
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| Reference Type | Citation | Progress Report Year | Document Sources |
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| Book Chapter | Cassin ME, Rajagopalan P. Polyelectrolyte multilayers for applications in hepatic tissue engineering. In: Picart C, Caruso F, Voegl J-C, eds. Layer-by-Layer Films for Biomedical Applications. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co., 2015, Chapter 22, pp. 487-506. |
R834998 (2013) R834998 (Final) |
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| Conference Proceedings | Ritz A, Murali TM. Pathway analysis with signaling hypergraphs. In: Proceedings of the 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, Newport Beach, CA, September 20-23, 2014, pp. 249-258. |
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| Journal Article | Bharadwaj A, Singh D, Ritz A, Tegge A, Poirel C, Kraivkivski P, Adames N, Luther K, Kale S, Peccoud J, Tyson T, Murali T. GraphSpace: stimulating interdisciplinary collaborations in network biology. BIOINFORMATICS 2017;33(19):3134-3436 |
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| Journal Article | Larkin AL, Rodrigues RR, Murali TM, Rajagopalan P. Designing a multicellular organotypic 3D liver model with a detachable, nanoscale polymeric Space of Disse. Tissue Engineering Part C: Methods 2013;19(11):875-884. |
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| Journal Article | Lasher CD, Rajagopalan P, Murali TM. Summarizing cellular responses as biological process networks. BMC Systems Biology 2013;7:68. |
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| Journal Article | Rajagopalan P, Kasif S, Murali TM. Systems biology characterization of engineered tissues. Annual Review of Biomedical Engineering 2013;15:55-70. |
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| Journal Article | Rita A, Poirel C, Tegge A, Sharp N, Simmons K, Powell A, Kale S, Murali T. Pathways on demand: automated reconstruction of human signaling networks. SYSTEMS BIOLOGY AND APPLICATIONS 2016;2(16002) |
R834998 (2013) R834998 (Final) |
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| Journal Article | Sam SA, Teel J, Tegge AN, Bharadwaj A, Murali TM. XTalkDB: a database of signaling pathway crosstalk. Nucleic Acids Research 2017;45(D1):D432-D439. |
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| Journal Article | Tegge AN, Sharp N, Murali TM. XTALK: a path-based approach for identifying crosstalk between signaling pathways. Bioinformatics 2016;32(2):242-251. |
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| Journal Article | Tegge A, Rodrigues R, Larkin A, Murali T, Pagagopalan P. Transcriptomic Analysis of Hepatic Cells in Multicellular Organotypic Liver Models. NATURE 2018;8(11306) |
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| Journal Article | Vu LT, Less RR, Rajagopalan P. The promise of organotypic hepatic and gastrointestinal models. Trends in Biotechnology 2014;32(8):406-413. |
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| Journal Article | Vu L, Orbach S, Ray W, Cassin ME, Rajagopalan P, Helm R. The hepatocyte proteome in organotypic rat liver models and the influence of the local microenvironment. PROTEOME SCIENCE 2017;15(12) |
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| Journal Article | Orbach SM, Cassin ME, Ehrich MF, Rajagopalan P. Investigating acetaminophen hepatotoxicity in multi-cellular organotypic liver models. Toxicology in Vitro 2017;42:10-20. |
R834998 (Final) |
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| Journal Article | Orbach SM, Ehrich MF, Rajagopalan P. High-throughput toxicity testing of chemicals and mixtures in organotypic multi-cellular cultures of primary human hepatic cells. Toxicology in Vitro 2018;51:83-94. |
R834998 (Final) |
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| Journal Article | Tegge AN, Rodrigues RR, Larkin AL, Vu L, Murali TM, Rajagopalan P. Transcriptomic analysis of hepatic cells in multicellular organotypic liver models. Scientific Reports 2018;8(1):11306. |
R834998 (Final) |
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| Patent/Patent Application | Rajagopalan P, Larkin AL. Organotypic 3D liver models with detachable nanoscale self-assembled multilayers and hepatic cells. U.S. Provisional Patent Application, April 2013. |
R834998 (2012) R834998 (2013) |
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| Presentation | Jain E, Rodrigues RR, Ehrich MF, Murali TM, Rajagopalan P. 3D liver models for investigating drug induced hepatotoxicity. Poster presented at the Society of Toxicology 52nd Annual Meeting & ToxExpo™, San Antonio, TX, March 10-14, 2013 (Abstract 1461). |
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| Presentation | Less RR, Rajagopalan P. Novel integrated in vitro gastrointestinal and hepatic cellular models for investigating drug toxicity. Presented at the American Institute of Chemical Engineers (AIChE) Annual Meeting, Atlanta, GA, November 16-21, 2014. |
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| Presentation | Murali TM. Top-down network analysis to drive bottom-up modeling of physiological processes. Presented at the ACM Conference on Bioinformatics, Computational Biology, and Biomedical Informatics, Washington, DC, September 22-25, 2013. |
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| Presentation | Murali TM. Hypergraphs for computational systems biology. Presented to the Department of Computer Science, Arizona State University, Tempe, AZ, April 2014. |
R834998 (2013) |
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| Presentation | Murali TM. Advice to tenure-track faculty. Presented at the Computing Research Association Career Mentoring Workshop, Washington, DC, February 24-25, 2014. |
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| Presentation | Murali TM. Pathways on demand: bridging top-down and bottom-up models of physiological processes. Presented to the Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, IL, March 2014. |
R834998 (2013) |
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| Presentation | Orbach SM, Cassin ME, Rajagopalan P. Engineering the hepatic sinusoidal microenvironment to investigate toxicity pathways. Presented at the American Institute of Chemical Engineers (AIChE) Annual Meeting, Atlanta, GA, November 16-21, 2014. |
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| Presentation | Orbach SM, Cassin ME, Rajagopalan P. Engineering the hepatic sinusoidal microenvironment to investigate toxicity pathways. Poster presented at the Biomedical Engineering Society (BMES) Annual Meeting, San Antonio, TX, October 22-25, 2014. |
R834998 (2013) R834998 (Final) |
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| Presentation | Rajagopalan P. Design of liver models using self-assembled polyelectrolyte multilayers. Presented at Duke Biomaterials Day, Duke University, Durham, NC, April 2012. |
R834998 (2013) |
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| Presentation | Rajagopalan P. 3D liver models to investigate hepatotoxicity. Presented at the Biomedical Engineering Society (BMES) Annual Meeting, Atlanta, GA, October 24-27, 2012. |
R834998 (2013) |
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| Presentation | Rajagopalan P. The design of 3D liver models using biopolymer-based polyelectrolyte multilayers. Presented at the International Conference on Bioinspired and Biobased Chemistry & Materials, Nice, France, October 3-5, 2012. |
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| Presentation | Rajagopalan P. Design and assembly of multi-cellular organs. Presented to the Department of Chemical Engineering, Virginia Commonwealth University, Richmond, VA, May 2013. |
R834998 (2013) |
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| Presentation | Rajagopalan P. Design and assembly of multi-cellular organs. Presented to the Department of Chemical Engineering, University of Kansas, Lawrence, KS, May 2013. |
R834998 (2013) |
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| Presentation | Rajagopalan P. The design of 3D liver models for inter-cellular signaling and toxicology studies. Presented to the Department of Chemical Engineering, Arizona State University, Tempe, AZ, April 2014. |
R834998 (2013) |
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| Presentation | Rajagopalan P. The design of organotypic liver models: studies on intercellular signaling and toxicology. Presented to the Department of Chemical Engineering, Texas A&M University, College Station, TX, August 2014. |
R834998 (2013) |
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| Presentation | Rajagopalan P. The design of 3D liver models for inter-cellular signaling and toxicology studies. Presented to the Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, March 2014. |
R834998 (2013) |
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| Presentation | Rajagopalan P. The design of 3D liver models for inter-cellular signaling and toxicology studies. Presented to the Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN, May 2014. |
R834998 (2013) |
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| Presentation | Rodrigues RR, Rajagopalan P, Murali TM. Transcriptome analysis of multi-cellular signaling in an organotypic 3D liver model. Poster presented at the Annual Meeting of the Biomedical Engineering Society (BMES), Seattle, WA, September 25-28, 2013. |
R834998 (2012) R834998 (2013) R834998 (Final) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.