Grantee Research Project Results
Publications Details for Grant Number R834786
Novel Immunological Approaches to Link Ambient Air Pollution Exposure to Health Outcomes
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Journal Article | Hew KM, Walker AI, Kohli A, Garcia M, Syed A, McDonald-Hyman C, Noth EM, Mann JK, Pratt B, Balmes J, Hammond SK, Eisen EA, Nadeau KC. Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells. Clinical & Experimental Allergy 2015;45(1):238-248. |
R834596 (2012) R834596 (Final) R834596C003 (Final) R834786 (Final) R835435 (2014) R835435 (2015) R835435 (2016) R835435 (Final) |
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| Journal Article | Kohli A, Garcia MA, Miller RL, Maher C, Humblet O, Hammond SK, Nadeau K. Secondhand smoke in combination with ambient air pollution exposure is associated with increased CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children. Clinical Epigenetics 2012;4(1):17 (16 pp.). |
R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2011) R834596C003 (2012) R834596C003 (Final) R834786 (2012) R835435 (Final) |
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| Journal Article | Liu J, Zhang L, Winterroth LC, Garcia M, Weiman S, Wong JW, Sunwoo JB, Nadeau KC. Epigenetically mediated pathogenic effects of phenanthrene on regulatory T cells. Journal of Toxicology 2013;2013:967029. |
R834596 (2012) R834596 (Final) R834596C003 (2012) R834596C003 (Final) R834786 (2012) R835435 (Final) |
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| Journal Article | Nadeau K, McDonald-Hyman C, Noth EM, Pratt B, Hammond SK, Balmes J, Tager I. Ambient air pollution impairs regulatory T-cell function in asthma. Journal of Allergy and Clinical Immunology 2010;126(4):845-852.e10. |
R834596 (2010) R834596 (2011) R834596C003 (2010) R834596C003 (2011) R834786 (2011) R835435 (Final) |
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| Presentation | Liu J, Cachola L, Nadeau KC. Polycyclic aromatic hydrocarbons methylate Foxp3 through the aryl hydrocarbon receptor in Treg. Presented at the American Academy of Allergy Asthma and Immunology (AAAAI) Annual Meeting, San Francisco, CA, March 18-22, 2011. |
R834786 (2011) |
not available |
| Presentation | Liu J, Nadeau KC. Diesel exhaust particles induce conversion of CD4+CD25hiCD127lo regulatory T cells to CD4+CD25neg effector T cells. Presented at the American Thoracic Society International Conference, Denver, CO, May 13-18, 2011. |
R834596 (2010) R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2010) R834596C003 (2011) R834596C003 (2012) R834786 (2011) |
not available |
| Presentation | McDonald C, Nadeau K. Ambient air pollution effects on Treg in asthma. Presented at the American Academy of Allergy, Asthma and Immunology (AAAAI) National Conference, New Orleans, LA, February 26-March 2, 2010. |
R834596 (2010) R834596 (2011) R834596 (2012) R834596 (Final) R834596C003 (2010) R834596C003 (2011) R834786 (2011) |
not available |
| Presentation | McDonald-Hyman C, Tager I, Nadeau KC. Ambient air pollution effects on Treg in asthma. Presented at the Gordon Research Conference-Atmospheric Chemistry, Waterville Valley, NH, August 23-28, 2009. |
R834786 (2011) |
not available |
| Presentation | Walker AI, Kohli A, Syed A, Eisen EA, Noth EM, Pratt B, Hammond SK, Nadeau K. Exposure to polycyclic aromatic hydrocarbons is associated with higher levels of total IgE, decreased function of T regulatory cells and an increase of asthma occurrence in children. Presented at the Annual Meeting of the American Academy of Allergy, Asthma & Immunology (AAAAI), San Antonio, TX, February 22-26, 2013. |
R834786 (2012) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.