Grantee Research Project Results
Publications Details for Grant Number R834796C003
Cardiovascular Consequences of Immune Modification by Traffic-Related Emissions
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| Reference Type | Citation | Progress Report Year | Document Sources |
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| Abstract | Yin F, Driscoll WS, Sulaiman D, Ramanathan G, Stewart JA, Mehrabian M, Beaven S, Lusis AJ, Rosenfeld ME, Araujo JA. Diesel exhaust induces hyperlipidemia in association with downregulation of PPAR alpha and changes in gut microbiota. Circulation 2016;134(Suppl 1):A20762 |
R834796 (2016) R834796C003 (2016) |
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| Abstract | Yin F, Driscoll WS, Sulaiman D, Ramanathan G, Stewart JA, Mehrabian M, Beaven S, Lusis AJ, Rosenfeld ME, Araujo JA. Diesel exhaust induces hyperlipidemia in association with downregulation of PPAR alpha and changes in gut microbiota. Circulation 2016;134(Suppl 1):A20762. |
R834796C003 (Final) |
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| Journal Article | Aragon MJ, Chrobak I, Brower J, Roldan L, Fredenburgh LE, McDonald JD, Campen MJ. Inflammatory and vasoactive effects of serum following inhalation of varied complex mixtures. Cardiovascular Toxicology 2016;16(2):163-171. |
R834796 (2015) R834796 (Final) R834796C003 (2015) R834796C003 (Final) |
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| Journal Article | Brower JB, Doyle-Eisele M, Moeller B, Stirdivant S, McDonald JD, Campen MJ. Metabolomic changes in murine serum following inhalation exposure to gasoline and diesel engine emissions. Inhalation Toxicology 2016;28(5):241-250. |
R834796 (2016) R834796 (Final) R834796C003 (2016) R834796C003 (Final) |
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| Journal Article | Campen MJ, Lund A, Rosenfeld M. Mechanisms linking traffic-related air pollution and atherosclerosis. Current Opinion in Pulmonary Medicine 2012;18(2):155-160. |
R833990 (2010) R833990 (2011) R834796 (2012) R834796 (2013) R834796 (2015) R834796 (Final) R834796C003 (2012) R834796C003 (2013) R834796C003 (Final) |
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| Journal Article | Campen M, Robertson S, Lund A, Lucero J, McDonald J. Engine exhaust particulate and gas phase contributions to vascular toxicity. Inhalation Toxicology 2014;26(6):353-360. |
R834796 (2014) R834796 (2015) R834796 (Final) R834796C003 (Final) |
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| Journal Article | Lund AK, Doyle-Eisele M, Lin Y-H, Arashiro M, Surratt JD, Holmes T, Schilling KA, Seinfeld JH, Rohr AC, Knipping EM, McDonald, JD. The effects of α-pinene versus toluene-derived secondary organic aerosol exposure on the expression of markers associated with vascular disease. Inhalation Toxicology 2013;25(6):309-324. |
R833990 (2011) R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R834796C002 (2015) R834796C002 (Final) R834796C003 (2013) |
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| Journal Article | Paffett ML, Zychowski KE, Sheppard L, Robertson S, Weaver JM, Lucas SN, Campen MJ. Ozone inhalation impairs coronary artery dilation via intracellular oxidative stress: evidence for serum-borne factors as drivers of systemic toxicity. Toxicological Sciences 2015;146(2):244-253. |
R834796 (2014) R834796 (2015) R834796 (Final) R834796C003 (Final) |
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| Journal Article | Robertson S, Colombo ES, Lucas SN, Hall PR, Febbraio M, Paffett ML, Campen MJ. CD36 mediates endothelial dysfunction downstream of circulating factors induced by O3 exposure. Toxicological Sciences 2013;134(2):304-311. |
R833990 (2011) R833990 (Final) R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R834796C003 (2013) R834796C003 (2016) R834796C003 (Final) |
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| Journal Article | Schisler JC, Ronnebaum SM, Madden M, Channell M, Campen M, Willis MS. Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions. Inhalation Toxicology 2015;27(5):272-280. |
R834796 (2015) R834796 (Final) R834796C003 (Final) |
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| Journal Article | Schisler J, Campen MJ, Madden M, and Willis MS. Transcriptional Endothelial Biosensor Response to Diesel-Induced Plasma Compositional Changes. Inhalation Toxicology. 2015, 27(5):272–280. |
R834796C003 (2016) |
not available |
| Journal Article | Tyler CR, Zychowski KE, Sanchez BN, Rivero V, Lucas S, Herbert G, Liu J, Irshad H, McDonald JD, Bleske BE, Campen MJ. Surface area-dependence of gas-particle interactions influences pulmonary and neuroinflammatory outcomes. Particle and Fibre Toxicology 2016;13(1):64 (18 pp.). |
R834796 (2016) R834796 (Final) R834796C003 (Final) |
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| Journal Article | Yin F, Lawal A, Ricks J, Fox JR, Larson T, Navab M, Fogelman AM, Rosenfeld ME, Araujo JA. Diesel exhaust induces systemic lipid peroxidation and development of dysfunctional pro-oxidant and pro-inflammatory high-density lipoprotein. Arteriosclerosis, Thrombosis, and Vascular Biology 2013;33(6):1153-1161. |
R834796 (2013) R834796 (2014) R834796 (2015) R834796 (Final) R834796C003 (2013) R834796C003 (2016) R834796C003 (Final) |
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| Journal Article | Peroxidation and Development of Dysfunctional Pro-Oxidant and Pro-Inflammatory High-Density Lipoprotein. Arterioscler Thromb Vasc Biol. 2013, 33(6):1153-61. |
R834796C003 (2016) |
not available |
| Journal Article | Aragon MJ, Chrobak I, Brower J, Roldan L, Fredenburgh LE, McDonald JD, Campen MJ:Inflammatory and Vasoactive Effects of Serum Following Inhalation of Varied Complex Mixtures. Cardiovascular toxicology. 2016, 16(2):163-171. |
R834796C003 (2016) |
not available |
| Journal Article | Campen MJ, Lund A, Rosenfeld M:Mechanisms linking traffic-related air pollution and atherosclerosis. Current opinion in pulmonary medicine. 2012, 18(2):155. |
R834796C003 (2016) |
not available |
| Journal Article | Campen M, Robertson S, Lund A, Lucero J, McDonald J:Engine exhaust particulate and gas phase contributions to vascular toxicity. Inhalation toxicology. 2014, 26(6):353-360. |
R834796C003 (2016) |
not available |
| Journal Article | Paffett ML, Sheppard L, Robertson S, Weaver J, Lucas SN, Campen MJ. Ozone inhalation enhances coronary artery constriction and impairs dilation via superoxide-dependent mechanisms. Toxicol Appl Pharmacol. 2015, In press. |
R834796C003 (2016) |
not available |
| Presentation | Campen MJ, McDonald JM, Rosenfeld ME, Lund AK. Cardiovascular consequences of immune modification by traffic-related emissions. Poster presented at the Clean Air Research Centers Annual Meeting, Boston, MA, June 21-22, 2012. |
R834796 (2012) R834796 (Final) R834796C003 (2013) |
not available |
| Presentation | Campen MJ, McDonald JM, Rosenfeld ME, Lund AK. Cardiovascular consequences of immune modification by traffic-related emissions. Poster presented at the Clean Air Research Centers Annual Meeting, Boston, MA, June 21-22, 2012. |
R834796 (2013) R834796 (2015) R834796C003 (2012) R834796C003 (2016) R834796C003 (Final) |
not available |
| Presentation | Campen MJ. Circulatory mechanisms underlying the systemic effects of inhaled nanoparticles and complex combustion mixtures:common pathways for diverse toxicants. Presented at the Society of Toxicology (SOT) 56th Annual Meeting & ToxExpo, Baltimore, MD, March 12-16, 2017. |
R834796 (2016) R834796 (Final) R834796C003 (Final) |
not available |
| Presentation | Campen M. Endothelial cell pattern recognition receptors, CD36 and LOX-1, contribute to responses to pollution-induced circulating factors. Presented at the Role of Circulating Factors in Mediating Systemic Toxicity of Inhaled Substances Symposium, Society of Toxicology (SOT) 53rd Annual Meeting & ToxExpo, Phoenix, AZ, March 23-27, 2014. |
R834796 (2014) R834796 (2015) R834796 (Final) R834796C003 (2015) R834796C003 (2016) R834796C003 (Final) |
not available |
| Presentation | Campen M, Heine L, Liu J, Brower J, Herbert G, Sanchez B, Zychowski K, Topper L, Doyle-Eisele M, McDonald J. Woodsmoke exposure alters serum composition that induces inflammatory gene expression and impairs ex vivo wound healing. Poster presented at the Society of Toxicology (SOT) 55th Annual Meeting & ToxExpo, New Orleans, LA, March 13-17, 2016. |
R834796 (Final) R834796C003 (2016) R834796C003 (Final) |
not available |
| Presentation | Liu J, Brower J, Doyle-Eisele M, Herbert G, Heine L, Sanchez B, Zychowski K, Topper L, McDonald J, Campen M. Serum-borne vascular toxicity following inhalation of mixed engine emissions and treated particles. Poster presented at the Society of Toxicology (SOT) 55th Annual Meeting & ToxExpo, New Orleans, LA, March 13-17, 2016. |
R834796 (Final) R834796C003 (2016) R834796C003 (Final) |
not available |
| Presentation | Mota RI, Norenberg JP, Daniels T, Lucas S, Campen M. Competitive receptor-binding assays of 111In-DANBIRT targeting of Luekocyte-function associated antigen-1 in a systemic inflammation rat model to inhaled ozone exposure. Poster presented at the Society of Nuclear Medicine and Molecular Imagine Annual Meeting, San Diego, CA, June 11-13, 2016. |
R834796 (Final) R834796C003 (2016) R834796C003 (Final) |
not available |
| Presentation | Ramanathan G, Zhao Y, Yin F, Rosenfeld ME, Yang X, Araujo JA. Liver transcriptomic and metabolic reprogramming after exposure to diesel exhaust. Poster presented at the Society of Toxicology (SOT) 55th Annual Meeting & ToxExpo, New Orleans, LA, March 13-17, 2016. |
R834796 (Final) R834796C003 (2016) R834796C003 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.