Grantee Research Project Results
Publications Details for Grant Number R832415C005
Ultrafine Particle Cell Interactions In Vitro: Molecular Mechanisms Leading To Altered Gene Expression in Relation to Particle Composition
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Book Chapter | Effects of inhaled fine/ultrafine particles combined with other air pollutants. | None | Elder ACP, Gelein R, Finkelstein J, Frampton M, Utell M, Carter J, Driscoll K, Kittelson, Watts W, Hopke P, Vincent R, Premkumari K, Oberdorster G | Elder ACP, Gelein R, Finkelstein J, Frampton M, Utell M, Carter J, Driscoll K, Kittelson, Watts W, Hopke P, Vincent R, Premkumari K, Oberdorster G. Effects of inhaled fine/ultrafine particles combined with other air pollutants. In: Heinrich U, ed. Effects of Air Contaminants on the Respiratory Tract - Interpretations from Molecules to Meta Analysis. Hannover, Germany: Fraunhofer IRB Verlag, 2004, pp. 53-68. |
R827354 (Final) R827354C001 (Final) R827354C003 (Final) R827354C004 (2003) R827354C004 (Final) R827354C005 (Final) R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R832415C005 (2011) |
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| Journal Article | Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains. | INHALATION TOXICOLOGY | Elder ACP, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdorster G | Elder ACP, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdorster G. Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains. Inhalation Toxicology 2004;16(6-7):461-471. |
R826784 (Final) R827354 (Final) R827354C003 (Final) R827354C004 (2003) R827354C004 (Final) R827354C005 (Final) R828046 (Final) R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R832415C005 (2011) |
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| Journal Article | Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate. | EXPERIMENTAL LUNG RESEARCH | Elder ACP, Gelein R, Oberdorster G, Finkelstein J, Notter R, Wang Z | Elder ACP, Gelein R, Oberdorster G, Finkelstein J, Notter R, Wang Z. Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate. Experimental Lung Research 2004;30(2):105-120. |
R827354 (Final) R827354C003 (Final) R827354C004 (2003) R827354C004 (Final) R827354C005 (Final) R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R832415C005 (2011) |
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| Journal Article | On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats. | INHALATION TOXICOLOGY | Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong C-H, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdorster G | Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong C-H, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdorster G. On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats. Inhalation Toxicology 2004;16(Suppl 1):41-53. |
R827354 (Final) R827354C003 (Final) R827354C004 (2003) R827354C004 (Final) R827354C005 (Final) R828046 (Final) R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R832415C005 (2011) |
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| Journal Article | Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate. | EXPERIMENTAL LUNG RESEARCH | Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdorster G | Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdorster G. Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate. Experimental Lung Research 2005;31(6):527-546. |
R827354 (Final) R827354C004 (Final) R827354C005 (Final) R828046 (Final) R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R832415C005 (2011) |
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| Journal Article | Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. | ENVIRONMENTAL HEALTH PERSPECTIVES | Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdorster G | Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdorster G. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environmental Health Perspectives 2006;114(8):1172-1178. |
R827354 (Final) R827354C004 (Final) R827354C005 (Final) R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2011) R832415C005 (2011) |
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| Journal Article | Particulate matter (PM) research centers (1999-2005) and the role of interdisciplinary center-based research. | ENVIRONMENTAL HEALTH PERSPECTIVES | Fanning EW, Froines JR, Utell MJ, Lippmann M, Oberdorster G, Frampton M, Godleski J, Larson TV | Fanning EW, Froines JR, Utell MJ, Lippmann M, Oberdorster G, Frampton M, Godleski J, Larson TV. Particulate Matter (PM) Research Centers (1999-2005) and the role of interdisciplinary center-based research. Environmental Health Perspectives 2009;117(2):167-174. |
R827351 (Final) R827352 (Final) R827353 (Final) R827354 (Final) R827355 (Final) R832415 (2010) R832415 (2011) R832415 (Final) R832415C003 (2011) R832415C004 (2011) R832415C005 (2011) R832416 (2009) R832416C003 (2009) |
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| Journal Article | Validation of an LDH assay for assessing nanoparticle toxicity. | None | Han X, Gelein R, Corson N, Wade-Mercer P, Jiang J, Biswas P, Finkelstein JN, Elder A, Oberdorster G | Han X, Gelein R, Corson N, Wade-Mercer P, Jiang J, Biswas P, Finkelstein JN, Elder A, Oberdorster G. Validation of an LDH assay for assessing nanoparticle toxicity. Toxicology 2011;287(1-3):99-104. |
R832415 (2011) R832415 (Final) R832415C004 (2011) R832415C005 (2011) |
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| Journal Article | Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics. | Journal of Toxicology and Environmental Health Part A | Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, Elder A, Han X, Gelein R, Finkelstein J, Oberdorster G | Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, Elder A, Han X, Gelein R, Finkelstein J, Oberdorster G. Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics. Journal of Toxicology and Environmental Health, Part A 2010;73(5-6):445-461. |
R832415 (2010) R832415 (2011) R832415 (Final) R832415C004 (2010) R832415C004 (2011) R832415C005 (2010) R832415C005 (2011) |
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| Journal Article | Use of indicator cell lines for determining inflammatory gene changes and screening the inflammatory potential of particulate and non-particulate stimuli. | INHALATION TOXICOLOGY | Singal M, Finkelstein JN | Singal M, Finkelstein JN. Use of indicator cell lines for determining inflammatory gene changes and screening the inflammatory potential of particulate and non-particulate stimuli. Inhalation Toxicology 2005;17(9):415-425. |
R827354 (Final) R827354C005 (Final) R832415 (2010) R832415 (Final) R832415C005 (2011) |
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| Journal Article | Amorphous silica particles promote inflammatory gene expression through the redox sensitive transcription factor, AP-1, in alveolar epithelial cells. | EXPERIMENTAL LUNG RESEARCH | Singal M, Finkelstein JN | Singal M, Finkelstein JN. Amorphous silica particles promote inflammatory gene expression through the redox sensitive transcription factor, AP-1, in alveolar epithelial cells. Experimental Lung Research 2005;31(6):581-597. |
R827354 (Final) R827354C005 (Final) R832415 (2010) R832415 (Final) R832415C005 (2011) |
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| Presentation | Mechanisms of low solubility particle-induced lung tumors. | None | Elder A | Elder A. Mechanisms of low solubility particle-induced lung tumors. Presented at the Society of Toxicology 45th Annual Meeting & ToxExpo, San Diego, CA, March 5-9, 2006 (speaker and co-chair). |
R832415 (Final) R832415C004 (2006) R832415C005 (2006) |
not available |
| Presentation | Hyperglycemia alters vascular endothelial responses to ultrafine particles in vitro. | None | Finkelstein JN, Reed C, Johnston C, Oberdorster G | Finkelstein JN, Reed C, Johnston C, Oberdorster G. Hyperglycemia alters vascular endothelial responses to ultrafine particles in vitro. Presented at the 2007 American Thoracic Society Meeting, San Francisco, CA, May 18-23, 2007. |
R832415C005 (2007) R832415C005 (2008) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.