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Abstract (5)
Journal Article (8)
Presentation (5)
Reference Type Citation Progress Report Year Document Sources
Abstract Hwang H, Simkhovich BZ, Kleinman MT, Kloner RA. The direct toxic effect of ultrafine particles on coronary flow: the importance of the hydroxyl radical. Journal of the American College of Cardiology 2008;51(10S1):A303. R831952 (Final)
 not available
Abstract Simkhovich BZ, Kleinman MT, Wold LE, Kloner RA. Direct and acute cardiotoxicity of ultrafine air pollutants in Langendorff-perfused young and old rat hearts. In: Abstracts of The Role of Air Pollutants in Cardiovascular Disease, U.S. EPA/NHLBI/NIEHS, Research Triangle Park, NC, October 12-13, 2006, p. 35. R831952 (Final)
 not available
Abstract Simkhovich BZ, Mehrian-Shai R, Hsu N, Lin SM, Feng G, Kleinman MT, Kloner RA. Cardiac pro-oxidant gene expression patterns are altered by chronic exposure to particulate air pollutants. A gene chip study. Journal of the American College of Cardiology 2009;53(10S):A145. R831952 (Final)
 not available
Abstract Simkhovich BZ, Gookin G, Meacher D, Willert P, Kleinman MT, Kloner RA. Pathologic changes to the heart induced by chronic exposure to air pollutants generated in traffic and the wildfires of Southern California in October 2007. Journal of the American College of Cardiology 2009;53(10S):A167-A168. R831952 (Final)
 not available
Abstract Wold LE, Simkhovich BZ, Nordlie MA, Kleinman MT, Sioutas C, Kloner RA. Direct and acute cardiotoxicity of ultrafine air pollutants. Journal of the American College of Cardiology 2006;47(4 Suppl 1):84A. R831952 (2005)
R831952 (Final)
 not available
Journal Article Hwang H, Kloner RA, Kleinman MT, Simkhovich BZ. Direct and acute cardiotoxic effects of ultrafine air pollutants in spontaneously hypertensive rats and Wistar-Kyoto rats. Journal of Cardiovascular Pharmacology and Therapeutics 2008;13(3):189-198. R831952 (Final)
Journal Article Kleinman MT, Araujo JA, Nel A, Sioutas C, Campbell A, Cong PQ, Li H, Bondy SC. Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways. Toxicology Letters 2008;178(2):127-130. R831952 (Final)
R832413 (2007)
R832413 (2008)
R832413 (2009)
R832413 (Final)
R832413C001 (2007)
R832413C001 (2008)
R832413C001 (Final)
Journal Article Simkhovich BZ, Marjoram P, Kleinman MT, Kloner RA. Direct and acute cardiotoxicity of ultrafine particles in young adult and old rat hearts. Basic Research in Cardiology 2007;102(6):467-475. R831952 (Final)
Journal Article Simkhovich BZ, Kleinman MT, Kloner RA. Air pollution and cardiovascular injury epidemiology, toxicology, and mechanisms. Journal of the American College of Cardiology 2008;52(9):719-726. R831952 (2005)
R831952 (Final)
Journal Article Simkhovich BZ, Kleinman MT, Kloner RA. Particulate air pollution and coronary heart disease. Current Opinion in Cardiology 2009;24(6):604-609. R831952 (Final)
Journal Article Simkhovich BZ, Kleinman MT, Willet P, Gookin G, Salazar K, Keebaugh A, Kloner RA. Chronically inhaled ambient particles cause cardiac inflammation in normal, diseased, and elderly rat hearts. Air Quality Atmosphere and Health 2011;4(1):27-36. R831952 (Final)
Journal Article Simkhovich BZ, Kleinman MT, Mehrian-Shai R, Hsu YH, Meacher D, Gookin G, Kinnon MM, Salazar K, Willet P, Feng G, Lin SM, Kloner RA. Chronic exposure to ambient particulate matter alters cardiac gene expression patterns and markers of oxidative stress in rats. Air Quality Atmosphere and Health 2011;4(1):15-25. R831952 (Final)
Journal Article Wold LE, Simkhovich BZ, Kleinman MT, Nordlie MA, Dow JS, Sioutas C, Kloner RA. In vivo and in vitro models to test the hypothesis of particle-induced effects on cardiac function and arrhythmias. Cardiovascular Toxicology 2006;6(1):69-78. R827352 (Final)
R831952 (2005)
R831952 (Final)
R832413 (2008)
R832413 (Final)
R832413C001 (2007)
R832413C001 (Final)
Presentation Hamade A, Sioutas C, Froines J, Kloner R, Kleinman M. Inflammatory and oxidant/antioxidant status of 22-month-old rats exposed to PM2.5 in Los Angeles, CA. Presented at the 24th Annual American Association for Aerosol Research Conference, Los Angeles, CA, October 17-21, 2005. R831952 (2005)
R831952 (Final)
 not available
Presentation Kleinman MT, Simkhovich BZ, Meacher D, Gookin G, Mac KM, Salazar K, Willet P, Kloner RA. Acute and sub-chronic cardiotoxic effects of inhaled ultrafine particles in spontaneously hypertensive rats and Wistar-Kyoto rats. Presented at the Society of Toxicology 49th Annual Meeting and ToxExpo, Salt Lake City, UT, March 7-11, 2010. R831952 (Final)
 not available
Presentation Kloner RA. Ischemia/myocardium molecular view. Presented at The Role of Air Pollutants in Cardiovascular Disease, U.S. EPA/NHLBI/NIEHS, Research Triangle Park, NC, October 12-13, 2006. R831952 (Final)
 not available
Presentation Wold LE, Simkhovich BZ, Kleinman MT, Nordlie MA, Dow JS, Sioutas C, Kloner RA. Ultra-fine particles isolated from ambient air and diesel fuel have direct cardiovascular mechanisms independent of pulmonary inflammation. Presented at the 2005 Young Investigators Forum of the American Heart Association Western States Affiliate at the University of California, Irvine, CA, September 30, 2005. R831952 (Final)
 not available
Presentation Wold LE, Simkhovich BZ, Nordlie MA, Kleinman MT, Sioutas C, Kloner RA. Direct and acute cardiotoxicity of ultrafine air pollutants. Presented at the American College of Cardiology 55th Annual Scientific Session, Atlanta, GA, March 11-14, 2006. R831952 (2005)
R831952 (Final)
 not available

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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