Grantee Research Project Results
Publications Details for Grant Number R835736C001
Mammosphere Bioreactor For Life-Stage Specific Toxicology
RFA:
Organotypic Culture Models for Predictive Toxicology Center (2013)
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Reference Type | Citation | Progress Report Year | Document Sources |
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Abstract | Auner A, Tasneem K, McCawley L, Markov D, Hutson S. Sorption of potential toxicants by PDMS in microfluidic devices. Bulletin of the American Physical Society 2017;62(13):BAPS.2017.SES.B2.6. |
R835736C001 (2017) R835736C001 (2018) |
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Abstract | Markov DA, Fryman P, McCawley LJ. Toxicant bioavailability when using low volume polymer based organ-on-a-chip bioreactors to study exposures to chemical contaminants. The Toxicologist, Supplement to Toxicological Sciences 2016;150(1):596 (Abstract No. 3541). |
R835736C001 (2016) R835736C001 (2018) |
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Journal Article | Auner AW, Tasneem KM, Markov DA, McCawley LJ, Hutson MS. Chemical-PDMS Binding Kinetics and Implications for Bioavailability in microfluidic Devices. Lab on a Chip 2019;19(5):864-874 |
R835736C001 (2018) R835736C001 (Final) R835736C005 (2018) |
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Journal Article | Hutson MS, Alexander PG, Allwardt V, Aronoff DM, Bruner-Tran KL, Cliffel DE, Davidson JM, Gough A, Markov DA, McCawley LJ, McKenzie JR, McLean JA, Osteen KG, Pensabene V, Samson PC, Senutovitch NK, Sherrod SD, Shotwell MS, Taylor DL, Tetz LM, Tuan RS, Vernetti LA, Wikswo JP. Organs-on-chips as bridges for predictive toxicology. Applied In Vitro Toxicology 2016;2(2):97-102. |
R835736 (2015) R835736 (2016) R835736 (2017) R835736C001 (2018) R835736C003 (2016) R835736C003 (2017) R835736C003 (2018) |
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Journal Article | Karolak A, Markov DA, McCawley LJ, Rejniak KA. Towards personalized computational oncology: from spatial models of tumour spheroids, to organoids, to tissues. Journal of the Royal Society Interface 2018;15(138):20170703. |
R835736C001 (2017) |
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Patent/Patent Application | Samson PC, Schaffer DK, Reiserer RS, Schatzki L, Markov DA, Britt CM, Wikswo JP. Pressure Regulation System, Pressure Release Valves Thereof, Passive Pressurized Fluid Reservoirs, and Applications of Same. International Patent Pending PCT/US19/47324, August 2019 |
R835736C001 (Final) R835736C005 (Final) |
not available |
Patent/Patent Application | Schaffer DK, Markov DA, Reiserer RS, McCawley LJ, Geuy MD, Britt CM, Wikswo JP. Cartridge Systems, Capacitive Pumps and Multi-Throw Valves and Pump-Valve Systems and Applications of Same.International Patent Pending, PCT/US19/4730, August 2019 |
R835736C001 (Final) |
not available |
Patent/Patent Application | Schaffer DK, Geuy M, Reiserer RS, Britt CM, Samson PC, Markov DA, Schatzki L, Wikswo JP. Fluidic Chips, Cartridges, and Connectors for Rotary Planar Pumps and Rotary Planar Valves. U.S. Patent Pending, June 2019 |
R835736C001 (Final) R835736C005 (Final) |
not available |
Patent/Patent Application | Wikswo JP, Reiserer RS, Schaffer DK, Markov DA, Britt CM. Multichannel Pumps and Applications of Same. International Patent Pending PCT/US19/47190, August 2019. |
R835736C001 (Final) R835736C005 (Final) |
not available |
Presentation | D.A. Markov, G. Bazilevich, P. Fryman, L.J. McCawley. Application of the Mammary Gland-Thick Tissue Bioreactor for Screening for the Effects of Potential Environmental Toxicants BMES, Philadelphia, PA , 2019 |
R835736C001 (Final) |
not available |
Presentation | Markov DA, Block III FE, Brown JA, McCawley LJ, Wikswo JP. Compact mechanatronic system for the perfusion, control, analysis, and maintenance of organ-on-chip microbioreactors. Presented at SLAS2016, the 5th Annual Society for Laboratory Automation and Screening International Conference & Exhibition, San Diego, CA, January 23-27, 2016. |
R835736 (2016) R835736 (2017) R835736C001 (2016) R835736C001 (2018) |
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Presentation | Markov DA. Advances in the development of organ-on-chip microbioreactors. Presented at the Aalborg University Medical Center, Aalborg, Denmark, June 2016. |
R835736 (2016) R835736 (2017) R835736C001 (2016) R835736C001 (2018) |
not available |
Presentation | Markov DA, Fryman P, McCawley LJ. Toxicant bioavailability when using low volume polymer based organ-on-a-chip bioreactors to study exposures to chemical contaminants. Poster presented at the Society of Toxicology 55th Annual Meeting & ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835736 (2016) R835736 (2017) R835736C001 (2016) R835736C001 (2018) |
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Presentation | Markov DA, Auner A, Schafer E, Fryman P, Hutson HS, McCawley LJ. Mammosphere vioreactor for life-stage specific toxicology: considerations for toxicant bioavailability in organ-on-chip bioreactors. Presented at the Society of Toxicology Satellite Meeting "Horizons and Challenges in Organotypic Culture Models for Predictive Toxicology," Baltimore, MD, March 11, 2017. |
R835736C001 (2017) R835736C001 (2018) |
not available |
Presentation | Markov DA. Advanced Systems For Perfusion, Control, Analysis, and Maintenance of Organ-on-chip Microbioreactors.Presented at: 3rd Annual STAR Organotypic Culture Models (OCM) for Predictive Toxicology Research Centers Progress Review: Implementation of Microphysiological Systems in Toxicological Assessments; May 2018, Durhan, NC |
R835736C001 (2018) |
not available |
Presentation | McCawley LJ. Physical dynamics of cancer response to chemotherapy in 3D microenvironments: a platform to examine complex physical and chemical microenvironments. Presented at the 7th Annual Symposium: Annual Physics of Cancer, Leipzig, Germany, October 4-6, 2016. |
R835736 (2016) R835736 (2017) R835736C001 (2016) R835736C001 (2017) R835736C001 (2018) |
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Presentation | McCawley LJ. Mammary Gland-Organotypic Culture Module (MG-OCM) as a microfluidic platform for assessment of toxicant exposures on organoid development. Presented at:FutureTox IV Progress to Maturity:Predictive Developmental and Reproductive Toxicology for Healthy Children November 2018, Arlington, VA. |
R835736C001 (2018) |
not available |
Presentation | McCawley, LJ. Mammary Gland-Organotypic Culture Module (MG-OCM) as a microfluidic platform for assessment of toxicant exposures on organoid development. Presented at: 3rd Annual STAR Organotypic Culture Models (OCM) for Predictive Toxicology Research Centers Progress Review:Implementation of Microphysiological Systems in Toxicological Assessments; May 2018. |
R835736C001 (2018) |
not available |
Presentation | D.A. Markov, E. Shafer, L.J. McCawley “Examining PDMS – Compound Interactions as a Function of PDMS Treatments in Organ-On-Chip Systems” BMES 2018, Atlanta GA, 2018 ". |
R835736C001 (2018) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.