Grantee Research Project Results
Publications Details for Grant Number R835736C005
Systems Engineering & Analysis for Organotypic Culture Models
RFA:
Organotypic Culture Models for Predictive Toxicology Center (2013)
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| Reference Type | Citation | Progress Report Year | Document Sources |
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| Journal Article | Auner AW, Tasneem KM, Markov DA, McCawley LJ, Hutson MS. Chemical-PDMS Binding Kinetics and Implications for Bioavailability in microfluidic Devices. Lab on a Chip 2019;19(5):864-874 |
R835736C001 (2018) R835736C001 (Final) R835736C005 (2018) |
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| Journal Article | Cyr KJ, Avaldi OM, Wikswo JP. Circadian hormone control in a human-on-a-chip:in vitro biology’s ignored component? Experimental Biology and Medicine 2017;242(17):1714-1731. |
R835736 (2017) R835736C005 (2017) |
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| Journal Article | Leung MC, Hutson MS, Seifert AW, Spencer RM, Knudsen TB. Computational modeling and simulation of genital tubercle development. Reproductive Toxicology 2016;64:151-161. |
R835736 (2015) R835736 (2016) R835736C005 (2016) |
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| Journal Article | Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL. Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle. Scientific Reports 2017;7:42296 (15 pp.). |
R835736 (2015) R835736 (2016) R835736C004 (2016) R835736C005 (2016) R835738 (2016) R835738C003 (2017) R835738C005 (2017) |
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| Journal Article | Watson DE, Hunziker R, Wikswo JP. Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology. Experimental Biology and Medicine 2017;242(16):1559-1572. |
R835736 (2017) R835736C005 (2017) |
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| Journal Article | Wikswo JP. Looking to the future of organs-on-chips: interview with Professor John Wikswo. Future science OA 2017;3(2):FSO163. |
R835736C005 (2017) |
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| Journal Article | Miller DR, McClain ES, Cliffel DE. Electrochemical Microphysiometry Detects Cellular Glutamate Up-take. Journal of The Electrochemical Society 2018;165(12):G3120-G3124. |
R835736 (Final) R835736C005 (2018) R835736C005 (Final) |
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| Journal Article | Rogers M, Sobolik T, Schaffer DK, Samson PC, Johnson AC, Owens P, Codreanu SG, Sherrod SD, McLean JA, Wikswo JP, Richmond A. Engineered microfluidic bioreactor for examining the three-dimensional breast tumor microenvironment Biomicrofluidics 2018;12(3):034102. |
R835736C005 (Final) |
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| Patent/Patent Application | Samson PC, Schaffer DK, Reiserer RS, Schatzki L, Markov DA, Britt CM, Wikswo JP. Pressure Regulation System, Pressure Release Valves Thereof, Passive Pressurized Fluid Reservoirs, and Applications of Same. International Patent Pending PCT/US19/47324, August 2019 |
R835736C001 (Final) R835736C005 (Final) |
not available |
| Patent/Patent Application | Schaffer DK, Markov DA, Reiserer RS, McCawley LJ, Geuy MD, Britt CM, Wikswo JP. Cartridge Systems, Capactive Pumps and Multi-Throw Valves and Pump-Valve Systems and Applications of Same. International Patent Pending August 2019. |
R835736C005 (Final) |
not available |
| Patent/Patent Application | Schaffer DK, Geuy M, Reiserer RS, Britt CM, Samson PC, Markov DA, Schatzki L, Wikswo JP. Fluidic Chips, Cartridges, and Connectors for Rotary Planar Pumps and Rotary Planar Valves. U.S. Patent Pending, June 2019 |
R835736C001 (Final) R835736C005 (Final) |
not available |
| Patent/Patent Application | Wikswo JP, Reiserer RS, Schaffer DK, Markov DA, Britt CM. Multichannel Pumps and Applications of Same. International Patent Pending PCT/US19/47190, August 2019. |
R835736C001 (Final) R835736C005 (Final) |
not available |
| Patent/Patent Application | Wilkso, John P. Integrated Organ-on-Chip Systems and Applications of the Same, US Patent, 10,078,075 B2, 2018. |
R835736C005 (2018) |
not available |
| Patent/Patent Application | Wilkso JP, Interconnections of Multiple Perfused Engineered Tissue Constructs and Microbioreactors, Multi-Microformulators and Applications of the Same. US Patent 10,023,832 B2, 2018 |
R835736C005 (2018) |
not available |
| Patent/Patent Application | Wikswo et Multicompartment Microfluidic Bioreactors, Cylindrical Rotary Valves and Applications of Same. Patent Pending Serial No. 62/677,468. 2018 |
R835736C005 (2018) |
not available |
| Patent/Patent Application | System for Extensible Cell Culture, Microdialysis Imaging, and Regional Chemical Delivery and Control. Patent Pending. 2018 |
R835736C005 (2018) |
not available |
| Presentation | Wikswo JP. Nanoscience and biology: connecting nano to micro and milli for in vitro interrogation and control. Presented at the NSF-sponsored Annual Nanoscale Science and Engineering Grantees Conference, Arlington, VA, December 9-10, 2015 (invited). |
R835736 (2015) R835736C005 (2015) |
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| Presentation | Wikswo JP. Organs on chips: bioreactors, sensors, controls and interconnects to support constructionist biology. Presented to the Department of Biomedical Engineering, Northwestern University, Evanston, IL, April 27-28, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) |
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| Presentation | Wikswo JP. Hands on with organ-on-a-chip workshop. Presented at the 3D Tissue Models Conference, San Diego, CA, August 29-31, 2016 (invited). |
R835736 (2016) R835736C005 (2016) |
not available |
| Presentation | Wikswo JP. In vitro modeling of the blood brain barrier using complex 3D models. Presented at the 3D Tissue Models Conference, San Diego, CA, August 29-31, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) |
not available |
| Presentation | Wikswo JP. Organs-on-chips, metabolomics, systems biology, and closing the hermeneutic circle of biology. Presented at the University of Tennessee Health Science Center, Memphis, TN, December 15, 2016 (invited). |
R835736 (2017) R835736C005 (2016) |
not available |
| Presentation | Wikswo JP. Organs on chips for drug development, toxicology, and systems biology: a distributed yet interconnected modular approach. Presented at the Organ-on-a-Chip World Congress 2016 & 3D-Culture, Boston, MA, July 7-8, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) |
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| Presentation | Wikswo JP. Human neurovascular unit on-a-chip: microscale systems for tissue-level response. Presented at the 56th Annual Meeting of the Teratology Society, San Antonio, TX, June 25-29, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) |
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| Presentation | Wikswo JP. Cutting-edge safety—preclinical in vitro models. Presented at American Society of Tropical Medicine & Hygiene (ASTMH), Atlanta, GA, November 13, 2016 (invited). |
R835736C005 (2016) |
not available |
| Presentation | Wikswo JP. Probing the complexities of biology and medicine: closing the hermeneutic circle with in vitro and in silico models. Presented at the Eighth Scientific Meeting of the TMJ Association, Bethesda, MD, September 11-13, 2016 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) |
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| Presentation | Wikswo JP. Hormonal modulation of organs-on-chips to recapitulate in vivo ADME tox profiles in vitro. Presented at the 3D Tissue Models Summit, Boston, MA, August 29-30, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
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| Presentation | Wikswo JP. Organs-on-chips: a developer's masterclass. Presented at the 3D Tissue Models Summit, Boston, MA, August 29-30, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
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| Presentation | Wikswo JP. Modular architectures and control strategies for coupled microphysiological systems. Presented at Eli Lilly, Indianapolis, IN, January 4, 2017 (invited). |
R835736 (2016) R835736 (2017) R835736C005 (2016) R835736C005 (2017) |
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| Presentation | Wikswo JP. Fitting iPSCs, 3D cell culture, tissue chips and microphysiological systems into the grand scheme of biology, medicine, pharmacology, and toxicology. Presented at the Select Biosciences Organ-on-a-Chip World Congress & 3D-Culture Conference, Boston. MA, July 10, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. Scientific and technical strengths and limitations of MPS for drug toxicity testing. Presented at The Toxicology Forum 43rd Annual Summer Meeting, Annapolis, MD, July 12, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. Analytical chemistry for understanding the physiology and pathology of 3D cellular models. Presented at the World Preclinical Congress, Boston, MA, June 13-15, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. Multichannel microformulators suitable for massively parallel automated design of biological experiments. Presented at the American Physical Society Meeting, New Orleans, LA, March 13-17, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. Organs on chips for drug discovery and development. Preseneted at the Eli Lilly Grand Rounds, Indianapolis, IN, March 22, 2017 (invited). |
R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. Topologies, analytics, and automation for microphysiological systems. Presented at the Select Biosciences Organ-on-a-Chip Europe Conference, Munich, Germany, May 10-11, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. The opportunities and challenges of engineered models of cancer: cells, hardware, analytics, and interpretation. Presented at the Physical Sciences-Oncology Network Annual Investigators Meeting, Cambridge, MA, October 17-19, 2017 (invited). |
R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. Strengths, limitations and applications of microphysiological systems for drug development. Presented at the FDA Toxicology Working Group Meeting, Washington, DC, October 26, 2017 (invited). |
R835736 (2017) R835736C005 (2017) |
not available |
| Presentation | Wikswo JP. Functional coupling of human microphysiological systems. Presented at the Roundtable on Science and Welfare in Laboratory Animal Use, Institute for Laboratory Animal Research, Washington, DC, October 5-6, 2017 (invited). |
R835736C005 (2017) |
not available |
| Presentation | International Organ-on-Chip Workshop:From Systems Biology to Societal Issues (Milan); Biomedical Advanced Research and Development Authority (BARDA) TechWatch; Gordon Conference on Cellular and Molecular Mechanisms of Toxicology; 4th PREDiCT 3D Tissue Models Summit; Briefing for the U.S. Army Combat Capabilities Development Command Chemical Biological Center (CCDC-CBC), Vander-bilt; SelectBIO Organ-on-a-Chip World Congress; NIH Workshop on Tissue Chip Platforms as Tools for Testing Biocompatibility and Biotoxicity of Biomaterials; 2019 Chemical and Biological Defense Science & Technology (CBD S&T) Conference; FDA Internal MPS and Stem Cell User Group. |
R835736C005 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.