Grantee Research Project Results
Publications Details for Grant Number R835612
Toxicogenetics of tetrachloroethylene metabolism and toxicity: Using Collaborative Cross mouse population approach to address remaining gaps in human health assessments
RFA:
Susceptibility and Variability in Human Response to Chemical Exposure (2013)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Journal Article | Target organ metabolism, toxicity, and mechanisms of trichloroethylene and perchloroethylene: key similarities, differences, and data gaps. | None | Cichocki JA, Guyton KZ, Guha N, Chiu WA, Rusyn I, Lash LH | Cichocki JA, Guyton KZ, Guha N, Chiu WA, Rusyn I, Lash LH. Target organ metabolism, toxicity, and mechanisms of trichloroethylene and perchloroethylene: key similarities, differences, and data gaps. Journal of Pharmacology and Experimental Therapeutics 2016;359(1):110-123. |
R835612 (2016) R835612 (Final) |
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| Journal Article | Impact of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene. | None | Cichocki JA, Furuya S, Konganti K, Luo Y-S, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I | Cichocki JA, Furuya S, Konganti K, Luo Y-S, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. Impact of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene. Journal of Pharmacology and Experimental Therapeutics 2017;361(1):17-28. |
R835612 (2016) R835612 (Final) |
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| Journal Article | Characterization of variability in toxicokinetics and toxicodynamics of tetrachloroethylene using the Collaborative Cross mouse population. | None | Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap AH, Wade T, Sweet S, Chiu WA, Threadgill DW, Rusyn I | Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap AH, Wade T, Sweet S, Chiu WA, Threadgill DW, Rusyn I. Characterization of variability in toxicokinetics and toxicodynamics of tetrachloroethylene using the Collaborative Cross mouse population. Environmental Health Perspectives 2017;125(5):057006 (12 pp.). |
R835612 (Final) |
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| Journal Article | Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice. | TOXICOLOGICAL SCIENCES | Cichocki JA, Luo YS, Furuya S, Venkatratnam A, Konganti K, Chiu, WA,Threadgill DW, Pogribny IP | Cichocki JA, Luo YS, Furuya S, Venkatratnam A, Konganti K, Chiu, WA, Threadgill DW, Pogribny IP. Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice. Toxicological Sciences 2019;167(1):126-137. |
R835612 (Final) |
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| Journal Article | PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice | TOXICOLOGY AND APPLIED PHARMACOLOGY | Dalaijamts C, Cichocki J, Luo Y, Rusyn I, Chiu W | Dalaijamts C, Cichocki J, Luo Y, Rusyn I, Chiu W. PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice. Toxicology and Applied Pharmacology 2020;400(115069). |
R835612 (Final) |
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| Journal Article | Comparative analysis of Rapid Equilibrium Dialysis (RED) and solid phase micro-extraction (SPME) methods for In Vitro-In Vivo extrapolation of environmental chemicals. | TOXICOLOGY IN VITRO | Ferguson KC, Luo YS, Rusyn I, Chiu WA | Ferguson KC, Luo YS, Rusyn I, Chiu WA. Comparative analysis of Rapid Equilibrium Dialysis (RED) and solid phase micro-extraction (SPME) methods for In Vitro-In Vivo extrapolation of environmental chemicals. Toxicology in Vitro2019;60:245-251 |
R835612 (Final) |
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| Journal Article | In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances | TOXICOLOGICAL SCIENCES | Luo Y, Ferguson K, Rusyn I, Chiu W | Luo Y, Ferguson K, Rusyn I, Chiu W. In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances. Toxicological Sciences 2020;174(2):168-177. |
R835612 (Final) |
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| Journal Article | Model systems and organisms for addressing inter- and intra-species variability in risk assessment | REGULATORY TOXICOLOGY AND PHARMACOLOGY | Rusyn I, Chiu W, Wright F | Rusyn I, Chiu W, Wright F. Model systems and organisms for addressing inter-and intra-species variability in risk assessment. REGULATORY TOXICOLOGY AND PHARMACOLOGY 2022;132(105197). |
R835612 (Final) |
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| Journal Article | Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. | None | Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar W, Konganti K, Threadgill DW, Gillespie KM, Aylor DL, Wright FA, Chiu WA, Rusyn I | Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar W, Konganti K, Threadgill DW, Gillespie KM, Aylor DL, Wright FA, Chiu WA, Rusyn I. Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Toxicological Sciences 2017;158(1):48-62. |
R835612 (Final) |
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| Presentation | Inter-individual variability in the relationship between toxicokinetics and toxicodynamics of tetrachoroethylene. | None | Chichocki JA, Furuya S, Venkatratnam A, Kanp A, Wade T, Sweet S, McDonald T, Chiu W, Threadgill D, Rusyn I | Chichocki JA, Furuya S, Venkatratnam A, Kanp A, Wade T, Sweet S, McDonald T, Chiu W, Threadgill D, Rusyn I. Inter-individual variability in the relationship between toxicokinetics and toxicodynamics of tetrachoroethylene. Poster presented at the Society of Toxicology's 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835612 (2015) R835612 (Final) |
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| Presentation | Non-alcoholic fatty liver disease as a modifier of perchloroethylene-induced toxicity. | None | Cichocki J, Furuya S, Luo Y-S, Pogribny I, Chiu WA, Threadgill DW, Rusyn I | Cichocki J, Furuya S, Luo Y-S, Pogribny I, Chiu WA, Threadgill DW, Rusyn I. Non-alcoholic fatty liver disease as a modifier of perchloroethylene-induced toxicity. Poster presented at the Society of Toxicology's 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835612 (2016) R835612 (Final) |
not available |
| Presentation | Simultaneous detection of the tetrachloroethylene metabolites S-(1,2,2-trichlorovinyl) glutathione, S-(1,2,2-trichlorovinyl)-L-cysteine, and N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine in multiple mouse tissues via ultra-high performance liquid chromatography electrospray ionization tandem mass spectrometry. | None | Luo Y-S, Cichocki J, McDonald TJ, Rusyn I | Luo Y-S, Cichocki J, McDonald TJ, Rusyn I. Simultaneous detection of the tetrachloroethylene metabolites S-(1,2,2-trichlorovinyl) glutathione, S-(1,2,2-trichlorovinyl)-L-cysteine, and N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine in multiple mouse tissues via ultra-high performance liquid chromatography electrospray ionization tandem mass spectrometry. Poster presented at the Society of Toxicology's 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835612 (2016) R835612 (Final) |
not available |
| Presentation | Investigation of inter-individual variability in response to trichloroethylene (TCE) or tetrachloroethylene (PCE) exposure using the Collaborative Cross mouse population model. | None | Venkatratnam A, Cichocki J, Furuya S, Chappell GA, Grimm FA, Sweet S, Wade T, Knap A, Kosyk O, Yoo HS, Vorpahl A, Lynch R, Hillhouse A, Threadgill DW, Rusyn I | Venkatratnam A, Cichocki J, Furuya S, Chappell GA, Grimm FA, Sweet S, Wade T, Knap A, Kosyk O, Yoo HS, Vorpahl A, Lynch R, Hillhouse A, Threadgill DW, Rusyn I. Investigation of inter-individual variability in response to trichloroethylene (TCE) or tetrachloroethylene (PCE) exposure using the Collaborative Cross mouse population model. Poster presented at the Complex Trait Community 14th Annual Meeting, Portland, OR, June 8-11, 2015. |
R835612 (2015) R835612 (Final) |
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| Presentation | A population-wide study of metabolism and toxicodynamics of trichloroethylene using Collaborative Cross mouse panel provides critical insights into the mechanisms of inter-individual variability. | None | Venkatratnam A, Furuya S, Kosyk O, Konganti K, Aylor D, Hillhouse A, Chiu WA, Threadgill DW, Rusyn I | Venkatratnam A, Furuya S, Kosyk O, Konganti K, Aylor D, Hillhouse A, Chiu WA, Threadgill DW, Rusyn I. A population-wide study of metabolism and toxicodynamics of trichloroethylene using Collaborative Cross mouse panel provides critical insights into the mechanisms of inter-individual variability. Presented at the Society of Toxicology's 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835612 (2016) R835612 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.