Grantee Research Project Results
Publications Details for Grant Number R835550
Identification and Scientific Validation of AOPS Involving Genomic and Nongenomic Intracellular Thyroid Hormone Signaling in Neurodevelopment
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| Reference Type | Citation | Progress Report Year | Document Sources |
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| Journal Article | Chen H, Streifel KM, Singh V, Yang D, Mangini L, Wulff H, Lein PJ. From the cover:BDE-47 and BDE-49 inhibit axonal growth in primary rat hippocampal neuron-glia co-cultures via ryanodine receptor-dependent mechanisms. Toxicological Sciences 2017;156(2):375-386. |
R835550 (Final) |
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| Journal Article | Dach K, Bendt F, Huebenthal U, Giersiefer S, Lein PJ, Heuer H, Fritschea E. BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action. Scientific Reports 2017;7:44861 (11 pp.). |
R835550 (Final) |
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| Journal Article | Frank DF, Miller GW, Harvey DJ, Brander SM, Geist J, Connon RE, Lein PJ. Bifenthrin causes transcriptomic alterations in mTOR and ryanodine receptor-dependent signaling and delayed hyperactivity in developing zebrafish (Danio rerio). Aquatic Toxicology 2018;200:50-61. |
R835550 (Final) R835799 (2017) |
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| Journal Article | Harrill JA, Chen H, Streifel KM, Yang D, Mundy WR, Lein PJ. Ontogeny of biochemical, morphological and functional parameters of synaptogenesis in primary cultures of rat hippocampal and cortical neurons. Molecular Brain 2015;8:10 (15 pp.). |
R835432 (2014) R835550 (Final) |
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| Journal Article | Klose J, TRigges J, Masjosthusmann S, Schmuck K, Bendt F, Hubenthal U, Petzsch P, Kohrer K, Koch K, Fritsche E. TBBPA Targets Converging Key Events of Human Oligodendrocyte Development Resulting in Two Novel AOPs. Altex 2021;38(2):215-234. |
R835550 (Final) |
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| Journal Article | Singh L, Pressly B, Mengeling BJ, Fettinger JC, Furlow JD, Lein PJ, Wulff H, Singh V. Chasing the elusive benzofuran impurity of the THR antagonist NH-3: synthesis, isotope labeling, and biological activity. Journal of Organic Chemistry 2016;81(5):1870-1876. |
R835164 (Final) R835550 (Final) |
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| Journal Article | Frank DF, Miller GW, Connon RE, Geist J, Lein PJ. Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95. PeerJ 2017;5:e4106. doi:10.7717/peerj.4106. |
R835550 (Final) |
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| Journal Article | Mengeling BJ, Wei Y, Dobrawa LN, Streekstra M, Louisse J, Singh V, Singh L, Lein PJ, Wulff H, Murk AJ, Furlow JD. A multi-tiered, in vivo, quantitative assay suite for environmental disruptors of thyroid hormone signaling. Aquatic Toxicology 2017;190:1-10. |
R835550 (Final) |
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| Presentation | Dach K, Giersiefer S, Heuer H, Fritsche E. Neurospheres as a 3D in vitro model for DNT testing: studying endocrine disruption of thyroid hormone signaling during brain development in a species-specific context. Poster presented at the 11th CONCAWE Symposium, 2015 CONCAWE Young Researcher Awards, Brussels, Belgium, February 23-24, 2015. |
R835550 (2015) R835550 (Final) |
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| Presentation | Dach K, Giersiefer S, Bendt F, Huebenthal U, Heuer H, Fritsche E. Characterization of molecular and cellular effects of thyroid hormone within an AOP frame for thyroid hormone disruption using human and murine neural progenitor cells. Poster presented at the 16th Annual Congress of the European Society for Alternative to Animal Testing (EUSAAT), Linz, Austria, September 20-23, 2015. |
R835550 (2015) R835550 (Final) |
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| Presentation | Giersiefer S. Species-specific effects of thyroid hormone on neurodevelopmental processes in vitro. Presented at the Arbeitstagung Experimentelle Schilddrüsenforschung (AESF) Working Conference (experimental thyroid research) as part of the Thyroid Trans Act (TTA) IC 1st International Conference, Jacobs University Bremen, Bremen, Germany, December 4-5, 2014. |
R835550 (2015) R835550 (Final) |
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| Presentation | Giersiefer S. Distinct actions of thyroid hormone on early neurodevelopmental processes of human and rodent NPCs in vitro. Poster presented at the Thyroid Trans Act (TTA) IC 1st International Conference, Jacobs University Bremen, Bremen, Germany, December 5-7, 2014. |
R835550 (2015) R835550 (Final) |
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| Presentation | Giersiefer S, Dach K, Heuer H, Fritsche E. Identification of AOPs involving disruption of thyroid hormone signaling in neurodevelopmental processes by using 3D neurospheres. Poster presented at the Society of Toxicology (SOT) 54th Annual Meeting and ToxExpoTM, San Diego, CA, March 22-26, 2015 (Abstract # 646). |
R835550 (2015) R835550 (Final) |
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| Presentation | Giersiefer S. Generation of the molecular basis for studying thyroid hormone disruption in neural progenitor cells of humans and rats. Presented at the 16th Annual Congress of the European Society for Alternative to Animal Testing (EUSAAT), Linz, Austria, September 20-23, 2015. |
R835550 (2015) R835550 (Final) |
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| Presentation | Hayakawa KA, Walter KM, Miller GW, Lein PJ. Gene expression of thyroid hormone signaling pathways during neurodevelopment. Poster presented at the Society of Toxicology (SOT) 54th Annual Meeting and ToxExpoTM, San Diego, CA, March 22-26, 2015 (Abstract # 1773). |
R835550 (2015) R835550 (Final) |
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| Presentation | Lein PJ. Identification of molecular, cellular and behavioral endpoints associated with developmental hyperthyroidism and hypothyroidism in larval zebrafish. Poster presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 13-17, 2016. |
R835550 (Final) |
not available |
| Presentation | Lein PJ. Neurodevelopmental endpoints modulated by thyroid hormone in primary rat neuron-glia co-cultures. Poster presented at the Society of Toxicology Annual Meeting, New Orleans, LA, March 13-17, 2016. |
R835550 (Final) |
not available |
| Presentation | Lein PJ. Developmental hyperthyroidism and hypothyroidism in larval zebrafish alter oligodendrocyte precursor cell proliferation and maturation. Presented at the American College of Toxicology 37th Annual Meeting, Baltimore, MD, November 6-9, 2016. |
R835550 (Final) |
not available |
| Presentation | Lein P. Thyroid hormone drives early neurodevelopmental processes of humans and rodents in vitro (Fritsche lab). Presented at the Bregenz Summer School on Endocrinology, Bregenz, Austria, August 2014. |
R835550 (2014) |
not available |
| Presentation | Lein P. BDE-47 and BDE-49 selectively disrupt axonal outgrowth in cultured hippocampal neurons (Lein lab). Presented at the Society of Toxicology 53rd Annual Meeting and ToxExpo, Phoenix, AZ, March 23-27, 2014. |
R835550 (2014) |
not available |
| Presentation | Lein P. Of mice and men: mechanistic studies on the developmental neurotoxicity of polybrominated diphenyl ethers (PBDEs) in a 3D in vitro model (Frische lab). Presented at Eurotox 2014: 50th Congres of the European Societies of Toxicology, Edinburgh, Scotland, September 7-10, 2014. |
R835550 (2014) |
not available |
| Presentation | Walter KM, Miller GW, Chang Y, Hayakawa KA, Draper BW, Lein P. Development of a zebrafish model to identify adverse outcome pathways linking thyroid hormone disruption to developmental neurotoxicity. Poster presented at the Society of Toxicology (SOT) 54th Annual Meeting and ToxExpoTM, San Diego, CA, March 22-26, 2015 (Abstract # 265). |
R835550 (2015) R835550 (Final) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.