Grantee Research Project Results
Final Report: The Role of IgG in Mouse Models of Food Allergy
EPA Grant Number: R834067Title: The Role of IgG in Mouse Models of Food Allergy
Investigators: Sperling, Anne I. , Bryce, Paul J.
Institution: University of Chicago , Northwestern University
EPA Project Officer: Aja, Hayley
Project Period: June 1, 2009 through May 31, 2011
Project Amount: $433,100
RFA: Exploratory Investigations in Food Allergy (2007) RFA Text | Recipients Lists
Research Category: Human Health
Objective:
Summary/Accomplishments (Outputs/Outcomes):
Conclusions:
The work carried out under this grant award has provided definitive results that have added to our understanding of food allergy. In Aim #1, we have established definitively that immune complexes are sufficient to diminish food allergy responses and that this occurs via CD32 through an IL-21 dependent mechanism. In Aim #2, we have defined that the regulatory T cell responses are important to induction and magnitude of responses while the dendritic cell is unlikely to be the cause of the loss of oral tolerance. This work has led to several new findings that were not obvious at the beginning of the study. Specifically, our existing data from allergic models in the lung showed that immune complexes assist in promoting allergyl; this is seemingly not the case in the intestine, where the opposite role is observed. Thus, together our studies have provided new insight into how the food allergy response occurs, and potential methods for how to correct these problems. Based on these studies novel strategies for the treatment of human food allergy disease may someday be tested.
Journal Articles on this Report : 1 Displayed | Download in RIS Format
Other project views: | All 6 publications | 1 publications in selected types | All 1 journal articles |
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Ganeshan K, Bryce PJ. Regulatory T cells enhance mast cell production of IL-6 via surface-bound TGF-β. Journal of Immunology 2012;188(2):594-603. |
R834067 (Final) |
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Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.