Grantee Research Project Results
2009 Progress Report: The Role of IgG in Mouse Models of Food Allergy
EPA Grant Number: R834067Title: The Role of IgG in Mouse Models of Food Allergy
Investigators: Sperling, Anne I. , Bryce, Paul J.
Institution: University of Chicago , Northwestern University
EPA Project Officer: Aja, Hayley
Project Period: June 1, 2009 through May 31, 2011
Project Period Covered by this Report: June 1, 2009 through May 31,2010
Project Amount: $433,100
RFA: Exploratory Investigations in Food Allergy (2007) RFA Text | Recipients Lists
Research Category: Human Health
Objective:
The purpose of this project was to assess the role of IgG and its receptors (the Fcγ receptors) in the responsiveness of food allergy. This would be investigated through collaboration between the two PIs of this research grant, Dr. Anne Sperling at the University of Chicago and Dr. Paul Bryce at Northwestern University. Each PI brings unique skills and knowledge to the project—Dr. Sperling possesses extensive experience in dendritic cells, Th2 immunity and the Fcγ receptors in airway models and Dr. Bryce has developed a murine model of food allergy that displays several hallmark aspects of clinical food allergy. The aims of the research are as follows:
Aim #1: Determine the role of FcγRIII signaling on dendritic cells in the induction of food allergy in a novel murine model.
Aim #2: Determine the role of IgG-mediated processes on anaphylaxis to oral antigen exposure.
Progress Summary:
Future Activities:
- Determine the Fcγ receptor involved in the decreased allergic response in mice given direct administration of allergen-specific IgG.
- Determine the mechanism by which the decrease is mediated in the mice given direct administration of allergen-specific IgG.
- Determine whether Tregs are responsible for the loss of gut tolerance to food allergens in our model.
Journal Articles:
No journal articles submitted with this report: View all 6 publications for this projectProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.