Grantee Research Project Results
Final Report: Technology Development and Transfer Core
EPA Grant Number: R827353C017Subproject: this is subproject number 017 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Health Effects Institute (2015 - 2020)
Center Director: Greenbaum, Daniel S.
Title: Technology Development and Transfer Core
Investigators: Coull, Brent , Schwartz, Joel , Lawrence, Joy , Wolfson, Mike , Koutrakis, Petros , Demokritou, Philip
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Air Quality and Air Toxics , Particulate Matter , Air
Objective:
The Technology Core led by Dr. Koutrakis focused on implementation and integration of the new technologies into the work of researchers at Harvard and a number of other research centers.
Summary/Accomplishments (Outputs/Outcomes):
In conjunction with the analytical and facilities core, we supported a number of exposure assessment studies through the development and provision of state-of-the-art personal, microenvironmental, and outdoor particulate and gaseous samplers. This core also supported use of the instruments in toxicological studies by operating and servicing the concentrator and by developing new concentrator technologies. As new particle samplers and generating systems were developed, they were made available to other Centers and research groups. We published a number of research papers documenting the performance of these instruments (Demokritou, et al., 2003; Demokritou, et al., 2004a; Gupta, et al., 2004), and we assisted a number of research groups in installation and operation of these systems (Savage, et al., 2003). These studies have already substantially improved our understanding of particle health effects.
References:
Demokritou P, Lee SJ, Ferguson ST, Koutrakis P. A compact multistage (cascade) impactor for the characterization of atmospheric aerosols. Journal of Aerosol Science 2004a;35(3):281-299.
Demokritou P, Gupta T, Ferguson S, Koutrakis P. Development of a high-volume concentrated ambient particles system (caps) for human and animal inhalation toxicological studies. Inhalation Toxicology 2003;15(2):111-129.
Gupta T, Demokritou P, Koutrakis P. Development and performance evaluation of a high-volume ultrafine particle concentrator for inhalation toxicological studies. Inhalation Toxicology 2004;16(13):851-862.
Savage ST, Lawrence J, Katz T, Stearns RC, Coull BA, Godleski JJ. Does the Harvard/U.S. Environmental Protection Agency ambient particle concentrator change the toxic potential of particles? Journal of the Air & Waste Management Association 2003;53(9):1088-1097.
Journal Articles on this Report : 20 Displayed | Download in RIS Format
| Other subproject views: | All 20 publications | 20 publications in selected types | All 20 journal articles |
|---|---|---|---|
| Other center views: | All 207 publications | 205 publications in selected types | All 204 journal articles |
| Type | Citation | ||
|---|---|---|---|
|
|
Demokritou P, Kavouras IG, Harrison D, Koutrakis P. Development and evaluation of an impactor for a PM2.5 speciation sampler. Journal of the Air & Waste Management Association 2001;51(4):514-523. |
R827353 (Final) R827353C017 (Final) R833626 (Final) |
Exit Exit |
|
|
Demokritou P, Kavouras IG, Ferguson ST, Koutrakis P. Development and laboratory performance evaluation of a personal multipollutant sampler for simultaneous measurements of particulate and gaseous pollutants. Aerosol Science and Technology 2001;35(3):741-752. |
R827353 (Final) R827353C017 (Final) |
Exit Exit Exit |
|
|
Demokritou P, Gupta T, Ferguson S, Koutrakis P. Development and laboratory characterization of a prototype coarse particle concentrator for inhalation toxicological studies. Journal of Aerosol Science 2002;33(8):1111-1123. |
R827353 (Final) R827353C017 (Final) R825270 (2000) R825270 (Final) |
Exit Exit Exit |
|
|
Demokritou P, Gupta T, Koutrakis P. A high volume apparatus for the condensational growth of ultrafine particles for inhalation toxicological studies. Aerosol Science and Technology 2002;36(11):1061-1072. |
R827353 (Final) R827353C017 (Final) R825270 (2000) R825270 (Final) |
Exit Exit |
|
|
Demokritou P, Gupta T, Ferguson S, Koutrakis P. Development and laboratory performance evaluation of a personal cascade impactor. Journal of the Air & Waste Management Association 2002;52(10):1230-1237. |
R827353 (Final) R827353C017 (Final) R825270 (2000) R825270 (Final) |
Exit Exit |
|
|
Demokritou P, Kavouras IG, Ferguson ST, Koutrakis P. Development of a high volume cascade impactor for toxicological and chemical characterization studies. Aerosol Science and Technology 2002;36(9):925-933. |
R827353 (Final) R827353C017 (Final) R825270 (2000) R825270 (Final) |
Exit Exit |
|
|
Demokritou P, Gupta T, Ferguson S, Koutrakis P. Development of a high-volume concentrated ambient particles system (CAPS) for human and animal inhalation toxicological studies. Inhalation Toxicology 2003;15(2):111-129. |
R827353 (Final) R827353C017 (Final) |
Exit Exit |
|
|
Demokritou P, Lee SJ, Koutrakis P. Development and evaluation of a high loading PM2.5 speciation sampler. Aerosol Science and Technology 2004;38(2):111-119. |
R827353 (Final) R827353C017 (Final) |
Exit Exit Exit |
|
|
Demokritou P, Lee SJ, Ferguson ST, Koutrakis P. A compact multistage (cascade) impactor for the characterization of atmospheric aerosols. Journal of Aerosol Science 2004;35(3):281-299. |
R827353 (Final) R827353C017 (Final) |
Exit Exit Exit |
|
|
Ding Y, Koutrakis P. Development of a dichotomous slit nozzle virtual impactor. Journal of Aerosol Science 2000;31(12):1421-1431. |
R827353 (Final) R827353C017 (Final) |
Exit Exit Exit |
|
|
Franklin M, Zeka A, Schwartz J. Association between PM2.5 and all-cause and specific-cause mortality in 27 US communities. Journal of Exposure Science and Environmental Epidemiology 2007;17(3):279-287. |
R827353 (Final) R827353C017 (Final) R832416 (2008) |
Exit Exit Exit |
|
|
Gupta T, Demokritou P, Koutrakis P. Development and performance evaluation of a high-volume ultrafine particle concentrator for inhalation toxicological studies. Inhalation Toxicology 2004;16(13):851-862. |
R827353 (Final) R827353C017 (Final) |
Exit Exit Exit |
|
|
Hopke PK, Ito K, Mar T, Christiansen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Liu H, Neas L, Pinto J, Stolzel M, Suh H, Paatero P, Thurston GD. PM source apportionment and health effects:1. Intercomparison of source apportionment results. Journal of Exposure Science & Environmental Epidemiology 2006;16(3):275-286. |
R827353 (Final) R827353C017 (Final) R827351 (Final) R827351C001 (Final) R827354 (Final) R827354C001 (Final) R827355 (Final) R827355C008 (Final) R832415 (2010) R832415 (2011) R832415 (Final) |
Exit Exit Exit |
|
|
Lee SJ, Demokritou P, Koutrakis P. Performance evaluation of commonly used impaction substrates under various loading conditions. Journal of Aerosol Science 2005;36(7):881-895. |
R827353 (Final) R827353C017 (Final) |
Exit Exit Exit |
|
|
Lee SJ, Demokritou P, Koutrakis P, Delgado-Saborit JM. Development and evaluation of personal respirable particulate sampler (PRPS). Atmospheric Environment 2006;40(2):212-224. |
R827353 (Final) R827353C017 (Final) |
Exit Exit Exit |
|
|
Liu Y, Sarnat JA, Coull BA, Koutrakis P, Jacob DJ. Validation of Multiangle Imaging Spectroradiometer (MISR) aerosol optical thickness measurements using Aerosol Robotic Network (AERONET) observations over the contiguous United States. Journal of Geophysical Research–Atmospheres 2004;109(D6):D06205 (9 pp.). |
R827353 (Final) R827353C017 (Final) |
Exit Exit Exit |
|
|
Liu Y, Park RJ, Jacob DJ, Li Q, Kilaru V, Sarnat JA. Mapping annual mean ground-level PM2.5 concentrations using Multiangle Imaging Spectroradiometer aerosol optical thickness over the contiguous United States. Journal of Geophysical Research–Atmospheres 2004;109(D22):D22206. |
R827353 (Final) R827353C017 (Final) |
Exit Exit Exit |
|
|
Liu Y, Sarnat JA, Kilaru V, Jacob DJ, Koutrakis P. Estimating ground-level PM2.5 in the eastern United States using satellite remote sensing. Environmental Science & Technology 2005;39(9):3269-3278. |
R827353 (Final) R827353C017 (Final) |
Exit Exit Exit |
|
|
Liu Y, Franklin M, Kahn R, Koutrakis P. Using aerosol optical thickness to predict ground-level PM2.5 concentrations in the St. Louis area:a comparison between MISR and MODIS. Remote Sensing of Environment 2007;107(1-2):33-44. |
R827353 (Final) R827353C017 (Final) |
Exit Exit Exit |
|
|
Savage ST, Lawrence J, Katz T, Stearns RC, Coull BA, Godleski JJ. Does the Harvard/U.S. Environmental Protection Agency Ambient Particle Concentrator change the toxic potential of particles? Journal of the Air & Waste Management Association 2003;53(9):1088-1097. |
R827353 (Final) R827353C014 (Final) R827353C017 (Final) |
Exit Exit Exit |
Supplemental Keywords:
RFA, Scientific Discipline, Health, PHYSICAL ASPECTS, Air, ENVIRONMENTAL MANAGEMENT, HUMAN HEALTH, Toxicology, particulate matter, Air Pollution Monitoring, Environmental Chemistry, air toxics, Epidemiology, Air Pollution Effects, Environmental Microbiology, Risk Assessments, Susceptibility/Sensitive Population/Genetic Susceptibility, Health Effects, Physical Processes, Environmental Monitoring, Atmospheric Sciences, Molecular Biology/Genetics, indoor air, Children's Health, genetic susceptability, Biology, Risk Assessment, particulates, microbiology, ambient air quality, chemical exposure, interindividual variability, molecular epidemiology, sensitive populations, monitoring, cardiopulmonary responses, human health effects, ambient air monitoring, indoor exposure, health risks, air pollutants, exposure and effects, PM 2.5, ambient air, biological response, ambient measurement methods, pulmonary disease, developmental effects, respiratory disease, exposure, lead, children, Human Health Risk Assessment, air pollution, particle exposure, biological mechanism , ambient monitoring, inhalation, pulmonary, assessment of exposure, susceptibility, particulate exposure, cardiopulmonary response, ambient particle health effects, human exposure, environmental health hazard, inhalation toxicology, human susceptibility, indoor air quality, inhaled particles, cardiopulmonary, air quality, respiratory, dosimetry, cardiovascular disease, genetic susceptibility, human health riskRelevant Websites:
http://www.hsph.harvard.edu/epacenter/epa_center_99-05/index.html Exit
Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R827353 Health Effects Institute (2015 - 2020) Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological
Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards
Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to
Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate
Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition,
and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters,
Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
20 journal articles for this subproject
Main Center: R827353
207 publications for this center
204 journal articles for this center