Grantee Research Project Results
2006 Progress Report: Johns Hopkins Center for Childhood Asthma in the Urban Environment
EPA Grant Number: R832139Center: Center for the Study of Childhood Asthma in the Urban Environment
Center Director: Hansel, Nadia
Title: Johns Hopkins Center for Childhood Asthma in the Urban Environment
Investigators: Breysse, Patrick N. , Matsui, Elizabeth C.
Current Investigators: Breysse, Patrick N. , Butz, Arlene , Diette, Greg , Wills-Karp, Marsha , Georas, Steven
Institution: The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
Project Period Covered by this Report: November 1, 2005 through October 31, 2006
Project Amount: $3,576,564
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The Administrative Core will continue to be responsible for fiscal and administrative activities of the Center. This Core arranges the monthly research conferences, weekly project meetings, quarterly principal investigator retreats, and meetings of the Outside Advisory Committee. The Core also assists in planning for Community Advisory Board meetings. A major administrative step that has occurred is that Dr. Peyton Eggleston has retired; and Dr. Patrick Breysse has become the Director of the Center and Dr. Gregory Diette becomes the Deputy Director.
The Center’s long term goals for years 09 to10 continue to be to understand how exposures to environmental pollutants and allergens may relate to airway inflammation and respiratory morbidity in children with asthma in the inner city of Baltimore and to develop effective strategies to reduce morbidity by changing these exposures. We are addressing these goals with four projects: 1) Epidemiology of Susceptibly to Particulates and Allergens in Asthma (Component B: Greg Diette, MD, MS) will examine the relationship of polymorphisms in genes encoding IL13, TLR4 and BADr and exposure to pollutants and allergen in the homes of asthmatic and control children; 2) A Randomized, Controlled Trial of Behavioral Changes in Home Exposure Control (Component C: Arlene Butz, ScD, RN) will conduct a randomized controlled clinical trial of methods to increase the effectiveness of current intervention methods to reduce hazardous exposures and their adverse health effects; 3) Mechanism of Particulate-Induced Allergic Asthma (Component D: Marsha Wills-Karp, PhD) will examine the mechanisms by which urban airborne particulate matter from may exacerbate an allergen-driven inflammatory response in the airways; and 4) Effects of Particulate Matter on Dendritic Cell Maturation (Component H: Steven Georas, MD) will examine the effect of Baltimore ambient particulates on maturation of peripheral blood monocytes to dendritic cells.
Future Activities:
The Administrative Core will continue to be responsible for fiscal and administrative policy and reports, for calling meetings, for maintaining records of all center meetings, for arranging meetings, and creating progress reports. This office will arrange the research conferences, as well as meetings of the Outside Advisory Committee, the Internal Advisory Committee and the Community Advisory Board. The Core will continue to arrange for the Center personnel to attend annual program meetings. The creation of any public communications will also originate from this office.
Journal Articles: 113 Displayed | Download in RIS Format
Other center views: | All 117 publications | 116 publications in selected types | All 113 journal articles |
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Type | Citation | ||
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Alberg AJ, Diette GB, Ford JG. Invited commentary: Attendance and absence as markers of health status—the example of active and passive cigarette smoking. American Journal of Epidemiology 2003;157(10):870-873. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C001 (2004) |
Exit Exit |
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Barekzi E, Roman J, Hise K, Georas S, Steinke JW. Lysophosphatidic Acid Stimulates Inflammatory Cascade in Airway Epithelial Cells. Prostaglandins, Leukotrienes & Essential Fatty Acids 2006;74(6):357-363. |
R832139 (2007) |
not available |
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Barnes KC, Caraballo L, Munoz M, Zambelli-Weiner A, Ehrlich E, Burki M, Jimenez S, Mathias RA, Stockton ML, Deindl P, Mendoza L, Hershey GK, Nickel R, Wills-Karp M. A novel promoter polymorphism in the gene encoding complement component 5 receptor 1 on chromosome 19q13.3 is not associated with asthma and atopy in three independent populations. Clinical and Experimental Allergy 2004;34(5):736-744. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C003 (2004) |
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Barnes KC, Grant AV, Gao P. A review of the genetic epidemiology of resistance to parasitic disease and atopic asthma:common variants for common phenotypes? Current Opinion in Allergy and Clinical Immunology 2005;5(5):379-385. |
R832139 (2006) |
Exit |
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Barnes KC. Genetic epidemiology of health disparities in allergy and clinical immunology. Journal of Allergy and Clinical Immunology 2006;117(2):243-254. |
R832139 (2006) R832139 (2007) R832139C001 (2007) |
Exit Exit Exit |
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Barnes KC, Grant AV, Baltadzhieva D, Zhang S, Berg T, Shao L, Zambelli-Weiner A, Anderson W, Nelsen A, Pillai S, Yarnall DP, Dienger K, Ingersoll RG, Scott AF, Fallin MD, Mathias RA, Beaty TH, Garcia JG, Wills-Karp M. Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families. Genes and Immunity 2006;7(1):27-35. |
R832139 (2006) R832139 (2007) |
Exit Exit Exit |
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Barnes KC, Grant A, Gao P, Baltadjieva D, Berg T, Chi P, Zhang S, Zambelli-Weiner A, Ehrlich E, Zardkoohi O, Brummet ME, Stockton M, Watkins T, Gao L, Gittens M, Wills-Karp M, Cheadle C, Beck LA, Beaty TH, Becker KG, Garcia JGN, Mathias RA. Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes. Journal of Allergy and Clinical Immunology 2006;118(1):70-77. |
R832139 (2006) R832139 (2007) R832139C001 (2007) |
Exit Exit Exit |
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Barnes KC, Grant AV, Hansel NN, Gao P, Dunston GM. African Americans with Asthma: Genetic Insights. Proceedings of the American Thoracic Society 2007;4(1):58-68. |
R832139 (2007) |
not available |
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Bartlett SJ, Krishnan JA, Riekert KA, Butz AM, Malveaux FJ, Rand CS. Maternal depressive symptoms and adherence to therapy in inner-city children with asthma. Pediatrics 2004;113(2):229-237. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C001 (2004) |
Exit Exit |
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Bezemer GFG, Bauer SM, Oberdorster G, Breysse PN, Pieters RHH, Georas SN, Williams MA. Activation of pulmonary dendritic cells and Th2-type inflammatory responses on instillation of engineered, environmental diesel emission source or ambient air pollutant particles in vivo. Journal of Innate Immunity 2011;3(2):150-166. |
R832139 (Final) R832415 (Final) |
Exit Exit |
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Bollinger ME, Butz A, Mudd K, Hamilton RG. Contamination of nebulizers with environmental allergens. Annals of Allergy Asthma & Immunology 2005;95(5):429-432. |
R832139 (2006) |
Exit |
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Bose S, Diette GB, Woo H, Koehler K, Romero K, Rule AM, Detrick B, Brigham E, McCormack MC, Hansel NN. Vitamin D Status Modifies the Response to Indoor Particulate Matter in Obese Urban Children with Asthma. Journal of Allergy and Clinical Immunology-In Practice2019;7(6):1815. |
R832139 (Final) R834510 (Final) |
Exit |
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Breysse PN, Buckley TJ, Williams D, Beck CM, Jo SJ, Merriman B, Kanchanaraksa S, Swartz LJ, Callahan KA, Butz AM, Rand CS, Diette GB, Krishnan JA, Moseley AM, Curtin-Brosnan J, Durkin NB, Eggleston PA. Indoor exposures to air pollutants and allergens in the homes of asthmatic children in inner-city Baltimore. Environmental Research 2005;98(2):167-176. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139 (2007) R832139 (Final) R832139C001 (2006) R832139C002 (2004) |
Exit Exit Exit |
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Breysse PN, Diette GB, Matsui EC, Butz AM, Hansel NN, McCormack MC. Indoor air pollution and asthma in children. Proceedings of the American Thoracic Society 2010;7(2):102-106. |
R832139 (Final) R834510 (2010) R834510 (2011) R834510 (Final) |
Exit Exit |
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Butz AM, Riekert KA, Eggleston P, Winkelstein M, Thompson RE, Rand C. Factors associated with preventive asthma care in inner-city children. Clinical Pediatrics 2004;43(8):709-719. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C002 (2004) |
Exit |
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Butz AM, Tsoukleris M, Donithan M, Hsu VD, Mudd K, Zuckerman IH, Bollinger ME. Patterns of inhaled antiinflammatory medication use in young underserved children with asthma. Pediatrics 2006;118(6):2504-2513. |
R832139 (2007) R832139 (Final) R832139C002 (2007) R832139C002 (Final) |
Exit Exit Exit |
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Butz AM, Tsoukleris MG, Donithan M, Hsu VD, Zuckerman I, Mudd KE, Thompson RE, Rand C, Bollinger ME. Effectiveness of nebulizer use--targeted asthma education on underserved children with asthma. Archives of Pediatric and Adolescent Medicine 2006;160(6):622-628. |
R832139 (2007) R832139C002 (2006) R832139C002 (2007) |
Exit |
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Butz AM, Walker J, Pulsifer M. Shared Decision Making in Children with Asthma. Pediatric Nursing 2007;33(2):111-116. |
R832139 (Final) R832139C002 (2007) |
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Butz AM, Walker J, Land CL, Vibbert C, Winkelstein M. Improving asthma communication in high-risk children. Journal of Asthma 2007;44(9):739-745. |
R832139 (Final) R832139C002 (Final) |
Exit Exit |
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Butz AM, Thompson RE, Tsoukleris MG, Donithan M, Hsu VD, Mudd K, Zuckerman IH, Bollinger ME. Seasonal patterns of controller and rescue medication dispensed in underserved children with asthma. Journal of Asthma 2008;45(9):800-806. |
R832139 (Final) R832139C002 (Final) |
Exit Exit |
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Butz A, Pham L, Lewis L, Lewis C, Hill K, Walker J, Winkelstein M. Rural children with asthma: impact of a parent and child asthma education program. Journal of Asthma 2005;42(10):813-821. |
R832139 (2006) |
Exit |
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Butz A. Evidence-Based Practice: What is the Evidence for Medication Adherence in Children? Journal of Pediatric Health Care 2006;20(5):338-341. |
R832139 (2007) R832139C002 (2007) |
not available |
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Butz A, Sellers MD, Land C, Walker J, Tsoukleris M, Bollinger ME. Factors affecting primary care provider and caregiver concordance for pediatric asthma medications. Journal of Asthma 2009;46(3):308-313. |
R832139 (Final) R832139C002 (Final) |
Exit Exit |
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Callahan KA, Eggleston PA, Rand CS, Kanchanaraksa S, Swartz LJ, Wood RA. Knowledge and practice of dust mite control by specialty care. Annals of Allergy, Asthma & Immunology 2003;90(3):302-307. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C002 (2004) |
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Cheadle C, Becker KG, Cho-Chung YS, Nesterova M, Watkins T, Wood W 3rd, Prabhu V, Barnes KC. A Rapid Method for Microarray Cross Platform Comparisons using Gene Expression Signatures. Molecular and Cellular Probes 2007;21(1):35-46. |
R832139 (2007) |
not available |
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Chen R, Roman J, Guo J, West E, McDyer J, Williams MA, Georas SN. Lysophosphatidic acid modulates the activation of human monocyte-derived dendritic cells. Stem Cells and Development 2006;15(6):797-804. |
R832139 (2007) |
not available |
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Curtin-Brosnan J, Matsui EC, Breysse P, McCormack MC, Hansel NN, Tonorezos ES, Eggleston PA, Williams DL, Diette GB. Parent report of pests and pets and indoor allergen levels in inner-city homes. Annals of Allergy, Asthma & Immunology 2008;101(5):517-523. |
R832139 (Final) R832139C001 (Final) |
Exit Exit |
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Diette GB, Krishnan JA, Wolfenden LL, Skinner EA, Steinwachs DM, Wu AW. Relationship of physician estimate of underlying asthma severity to asthma outcomes. Annals of Allergy, Asthma & Immunology 2004;93(6):546-552. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C001 (2004) |
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Diette GB, Patino CM, Merriman B, Paulin L, Riekert K, Okelo S, Thompson K, Krishnan JA, Quartey R, Perez-Williams D, Rand C. Patient factors that physicians use to assign asthma treatment. Archives of Internal Medicine 2007;167(13):1360-1366. |
R832139 (2007) R832139 (Final) R832139C001 (2007) R832139C001 (Final) |
Exit Exit Exit |
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Eggleston PA. Cockroach allergen abatement in inner-city homes. Annals of Allergy, Asthma & Immunology 2003;91(6):512-514. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C002 (2004) |
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Eggleston PA. Environmental control for fungal allergen exposure. Current Allergy and Asthma Reports 2003;3(5):424-429. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C002 (2004) |
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Eggleston PA, Butz A, Rand C, Curtin-Brosnan J, Kanchanaraksa S, Swartz L, Breysse P, Buckley T, Diette G, Merriman B, Krishnan JA. Home environmental intervention in inner-city asthma:a randomized controlled clinical trial. Annals of Allergy, Asthma & Immunology 2005;95(6):518-524. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139 (2007) R832139 (Final) R832139C001 (2006) R832139C002 (2005) R832139C002 (2006) R832139C003 (2005) |
Exit Exit Exit |
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Eggleston PA. Improving indoor environments: reducing allergen exposures. Journal of Allergy and Clinical Immunology 2005;116(1):122-126. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139 (2007) R832139C002 (2005) R832139C003 (2005) |
Exit Exit Exit |
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Eggleston PA, Diette G, Lipsett M, Lewis T, Tager I, McConnell R, Chrischilles E, Lanphear B, Miller R, Krishnan J. Lessons learned for the study of childhood asthma from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1430-1436. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139C002 (2005) R832139C003 (2005) R826710 (Final) R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R829389 (Final) R831710 (2004) R831710 (2005) R831710 (Final) R831861 (2005) R831861 (2006) R831861C001 (2006) R832141 (2006) R832141 (2007) R832141 (Final) |
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Ferrari E, Tsay A, Eggleston PA, Spisni A, Chapman MD. Environmental detection of mouse allergen by means of immunoassay for recombinant Mus m 1. Journal of Allergy and Clinical Immunology 2004;114(2):341-346. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C002 (2004) |
Exit Exit |
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Gao L, Grant AV, Rafaels N, Stockton-Porter M, Watkins T, Gao P, Chi P, Munoz M, Watson A, Dunston G, Togias A, Hansel N, Sevransky J, Maloney JP, Moss M, Shanholtz C, Brower R, Garcia JGN, Grigoryev DN, Cheadle C, Beaty TH, Mathias RA, Barnes KC. Polymorphisms in the Myosin Light Chain Kinase Gene that Confer Risk of Severe Sepsis are Associated with a Lower Risk of Asthma. Journal of Allergy and Clinical Immunology 2007;119(5):1111-1118. |
R832139 (2007) |
not available |
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Gao P-S, Shimizu K, Grant AV, Rafaels N, Zhou L-F, Hudson SA, Konno S, Zimmermann N, Araujo MI, Ponte EV, Cruz AA, Nishimura M, Su S-N, Hizawa N, Beaty TH, Mathias RA, Rothenberg ME, Barnes KC, Bochner BS. Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma. European Journal of Human Genetics 2010;18(6):713-719. |
R832139 (Final) |
Exit Exit Exit |
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Garg A, Serwint J, Higman S, Kanof A, Schell D, Colon I, Butz A. Self-Efficacy at Smoking Cessation Counseling Parents in Primary Care: An Office-Based Intervention for Pediatricians and Family Physicians. Clinical Pediatrics 2007;46(3):252-257. |
R832139 (2007) R832139C002 (2007) |
not available |
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Georas SN. Inhaled glucocorticoids, lymphocytes, and dendritic cells in asthma and obstructive lung diseases. Proceedings of the American Thoracic Society 2004;1(3):215-221. |
R832139 (Final) R832139C004 (Final) |
Exit Exit Exit |
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Georas SN, Guo J, De Fanis U, Casolaro V. T-helper type 2 regulation in allergic disease. European Respiratory Journal 2005;26(6):1119-1137. |
R832139 (2006) R832139 (Final) R832139C004 (Final) |
Exit Exit Exit |
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Georas SN, Berdyshev E, Hubbard W, Gorshkova IA, Usatyuk PV, Saatian B, Myers AC, Williams MA, Xiao HQ, Liu M, Natarajan V. Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge. Clinical and Experimental Allergy 2007;37(3):311-322. |
R832139 (2007) R832139 (Final) R832139C004 (Final) |
Exit |
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Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, Buckley T, Breysse P, Keeler G, de Villiers T, McConnell R. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1447-1454. |
R832139 (2006) R826708 (2000) R826708 (2001) R826708 (2002) R826708 (Final) R826710 (Final) R827027 (2002) R831845 (2005) R831861 (2004) R831861 (2005) R831861 (2006) R831861 (Final) R831861C001 (2006) R831861C001 (Final) R831861C002 (Final) R831861C003 (2006) R831861C003 (Final) R832141 (2006) R832141 (2007) R832141 (Final) |
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Guajardo JR, Schleifer KW, Daines MO, Ruddy RM, Aronow BJ, Wills-Karp M, Hershey GK. Altered gene expression profiles in nasal respiratory epithelium reflect stable versus acute childhood asthma. Journal of Allergy and Clinical Immunology 2005;115(2):243-251. |
R832139 (2007) R832139C003 (2006) |
Exit Exit Exit |
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Hansel NN, Hilmer SC, Georas SN, Cope LM, Guo J, Irizarry RA, Diette GB. Oligonucleotide-microarray analysis of peripheral-blood lymphocytes in severe asthma. The Journal of Laboratory and Clinical Medicine 2005;145(5):263-274. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139 (2007) R832139C001 (2005) R829458 (2005) |
Exit Exit Exit |
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Hansel NN, Eggleston PA, Krishnan JA, Curtin-Brosnan J, Rand CS, Patino CM, Diette GB. Asthma-related health status determinants of environmental control practices for inner-city preschool children. Annals of Allergy, Asthma & Immunology 2006;97(3):409-417. |
R832139 (2007) R832139C001 (2007) |
Exit |
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Hansel NN, Rand CS, Krishnan JA, Okelo S, Breysse PN, Eggleston PA, Matsui E, Curtin-Brosnan J, Diette GB. Influence of caregivers' health beliefs and experiences on their use of environmental control practices in homes of pre-school children with asthma. Pediatric Asthma, Allergy & Immunology 2006;19(4):231-242. |
R832139 (2007) R832139C001 (2007) |
Exit |
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Hansel NN, Diette GB. Gene expression profiling in human asthma. Proceedings of the American Thoracic Society 2007;4(1):32-36. |
R832139 (2007) R832139 (Final) R832139C001 (2007) R832139C001 (Final) |
Exit Exit Exit |
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Hansel NN, Breysse PN, McCormack MC, Matsui EC, Curtin-Brosnan J, Williams DL, Moore JL, Cuhran JL, Diette GB. A longitudinal study of indoor nitrogen dioxide levels and respiratory symptoms in inner-city children with asthma. Environmental Health Perspectives 2008;116(10):1428-1432. |
R832139 (Final) R832139C001 (Final) |
Exit |
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Hawlisch H, Wills-Karp M, Karp CL, Kohl J. The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma. Molecular Immunology 2004;41(2-3):123-131. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C003 (2004) |
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Huang I-C, Frangakis C, Dominici F, Diette GB, Wu AW. Application of a propensity score approach for risk adjustment in profiling multiple physician groups on asthma care. Health Services Research 2005;40(1):253-278. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139 (2007) R832139 (Final) R832139C001 (2004) R832139C001 (2006) |
Exit Exit |
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Huang I-C, Dominici F, Frangakis C, Diette GB, Damberg CL, Wu AW. Is risk-adjustor selection more important than statistical approach for provider profiling? Asthma as an example. Medical Decision Making 2005;25(1):20-34. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139 (Final) R832139C001 (2005) R832139C001 (2006) |
Exit Exit Exit |
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Huang I-C, Diette GB, Dominici F, Frangakis C, Wu AW. Variations of physician group profiling indicators for asthma care. The American Journal of Managed Care 2005;11(1):38-44. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C001 (2005) |
Exit Exit |
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Israel BA, Parker EA, Rowe Z, Salvatore A, Minkler M, Lopez J, Butz A, Mosley A, Coates L, Lambert G, Potito PA, Brenner B, Rivera M, Romero H, Thompson B, Coronado G, Halstead S. Community-based participatory research:lessons learned from the Centers for Children's Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1463-1471. |
R832139 (2006) R826710 (Final) R829391 (2004) R829391 (2005) R829391 (2006) R829391C005 (2006) R831709 (2005) R831709 (2007) R831709C003 (2005) R831709C003 (2006) R831710 (2004) R831710 (2005) R831710 (Final) R831710C001 (2006) R831710C002 (2006) R831710C004 (2006) R831711 (2005) R831711 (2006) R831711 (2007) R831711 (Final) R831711C001 (2006) R831711C002 (2006) R831711C003 (2006) |
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Keen JC, Cianferoni A, Florio G, Guo J, Chen R, Roman J, Wills-Karp M, Casolaro V, Georas SN. Characterization of a novel PMA-inducible pathway of interleukin-13 gene expression in T cells. Immunology 2006;117(1):29-37. |
R832139 (2006) R832139 (2007) R832139C001 (2007) |
Exit Exit Exit |
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Kohl J, Baelder R, Lewkowich IP, Pandey MK, Hawlisch H, Wang L, Best J, Herman NS, Sproles AA, Zwirner J, Whitsett JA, Gerard C, Sfyroera G, Lambris JD, Wills-Karp M. A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma. Journal of Clinical Investigation 2006;116(3):783-796. |
R832139 (2007) R832139C003 (2006) R832139C003 (2007) |
Exit Exit Exit |
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Kohl J, Wills-Karp M. Complement regulates inhalation tolerance at the dendritic cell/T cell interface. Molecular Immunology 2007;44(1-3):44-56. |
R832139 (Final) R832139C003 (2007) |
Exit |
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Kohl J, Wills-Karp M. A dual role for complement in allergic asthma. Current Opinion in Pharmacology 2007;7(3):283-289. |
R832139 (Final) R832139C003 (2007) |
Exit |
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Krishnan V, Diette GB, Rand CS, Bilderback AL, Merriman B, Hansel NN, Krishnan JA. Mortality in patients hospitalized for asthma exacerbations in the United States. American Journal of Respiratory and Critical Care Medicine 2006;174(6):633-638. |
R832139 (2007) R832139C001 (2007) |
Exit Exit |
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Levin A, Mathias R, Huang L, Roth L, Daley D, Myers R, Himes B, Romieu I, Yang M, Eng C, Park J, Zoratti K, Gignoux C, Torgerson D, Galanter J, Huntsman S, Nguyen E, Becker A, Chan-Yeung M, Kozyrskyj A, Dwok P, Gilliland F, Gauderman W, Bleecker E, Raby B, Meyers D, London S, Martinez F, Weiss S, Burchard E, Nicolae D, Ober C, Barnes K, WIlliams L. A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2013;131(4):1176-1184. |
R832139 (Final) R826708 (Final) R831861 (Final) |
Exit Exit |
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Lewkowich IP, Herman NS, Schleifer KW, Dance MP, Chen BL, Dienger KM, Sproles AA, Shah JS, Kohl J, Belkaid Y, Wills-Karp M. CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. Journal of Experimental Medicine 2005;202(11):1549-1561. |
R832139 (2006) R832139 (2007) R832139C003 (2006) |
Exit Exit |
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Limb SL, Brown KC, Wood RA, Wise RA, Eggleston PA, Tonascia J, Adkinson NF Jr. Irreversible lung function deficits in young adults with a history of childhood asthma. Journal of Allergy and Clinical Immunology 2005;116(6):1213-1219. |
R832139 (2006) |
Exit Exit Exit |
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Limb SL, Brown KC, Wood RA, Wise RA, Eggleston PA, Tonascia J, Hamilton RG, Adkinson Jr NF. Adult asthma severity in individuals with a history of childhood asthma. Journal of Allergy and Clinical Immunology 2005;115(1):61-66. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139 (2007) R832139C002 (2005) R832139C003 (2005) |
Exit Exit |
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Mathias RA, Gao P, Goldstein JL, Wilson AF, Pugh EW, Furbert-Harris P, Dunston GM, Malveaux FJ, Togias A, Barnes KC, Beaty TH, Huang S-K. A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q. BMC Genetics 2006;7:38. |
R832139 (2007) |
not available |
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Mathias RA, Grant AV, Rafaels N, Hand T, Gao L, Vergara C, Tsai YJ, Yang M, Campbell M, Foster C, Gao P, Togias A, Hansel NN, Diette G, Adkinson NF, Liu MC, Faruque M, Dunston GM, Watson HR, Bracken MB, Hoh J, Maul P, Maul T, Jedlicka AE, Murray T, Hetmanski JB, Ashworth R, Ongaco CM, Hetrick KN, Doheny KF, Pugh EW, Rotimi CN, Ford J, Eng C, Burchard EG, Sleiman PMA, Hakonarson H, Forno E, Raby BA, Weiss ST, Scott AF, Kabesch M, Liang L, Abecasis G, Moffatt MF, Cookson WOC, Ruczinski I, Beaty TH, Barnes KC. A genome-wide association study on African-ancestry populations for asthma. The Journal of Allergy and Clinical Immunology 2010;125(2):336-346. |
R832139 (Final) R834510 (2010) R834510 (2011) R834510 (Final) |
Exit Exit Exit |
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Matsui EC, Wood RA, Rand C, Kanchanaraksa S, Swartz L, Curtin-Brosnan J, Eggleston PA. Cockroach allergen exposure and sensitization in suburban middle-class children with asthma. Journal of Allergy and Clinical Immunology 2003;112(1):87-92. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C002 (2004) |
Exit |
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Matsui EC, Wood RA, Rand C, Kanchanaraksa S, Swartz L, Eggleston PA. Mouse allergen exposure and mouse skin test sensitivity in suburban, middle-class children with asthma. The Journal of Allergy and Clinical Immunology 2004;113(5):910-915. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139 (Final) R832139C001 (Final) R832139C002 (2004) |
Exit Exit Exit |
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Matsui EC, Krop EJM, Diette GB, Aalberse RC, Smith AL, Eggleston PA. Mouse allergen exposure and immunologic responses: IgE-mediated mouse sensitization and mouse-specific IgG and IgG4 levels. Annals of Allergy, Asthma & Immunology 2004;93(2):171-178. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C001 (2004) |
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Matsui EC, Diette GB, Krop EJM, Aalberse RC, Smith AL, Curtin-Brosnan J, Eggleston PA. Mouse allergen-specific immunoglobulin G and immunoglobulin G4 and allergic symptoms in immunoglobulin E-sensitized laboratory animal workers. Clinical & Experimental Allergy 2005;35(10):1347-1353. |
R832139 (2006) R832139 (2007) R832139 (Final) R832139C001 (2006) |
Exit |
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Matsui EC, Simons E, Rand C, Butz A, Buckley TJ, Breysse P, Eggleston PA. Airborne mouse allergen in the homes of inner-city children with asthma. Journal of Allergy and Clinical Immunology 2005;115(2):358-363. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139 (2007) R832139C002 (2005) R832139C003 (2005) |
Exit Exit |
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Matsui EC, Diette GB, Krop EJ, Aalberse RC, Smith AL, Eggleston PA. Mouse allergen-specific immunoglobulin G4 and risk of mouse skin test sensitivity. Clinical & Experimental Allergy 2006;36(8):1097-1103. |
R832139 (2007) R832139 (Final) R832139C001 (2006) R832139C001 (2007) |
Exit |
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Matsui EC, Eggleston PA, Buckley TJ, Krishnan JA, Breysse P, Rand C, Diette GB. Household mouse allergen exposure and asthma morbidity in inner-city preschool children. Annals of Allergy, Asthma & Immunology 2006;97(4):514-520. |
R832139 (2007) R832139C001 (2007) |
Exit |
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Matsui EC, Eggleston PA, Breysse PN, Rand CS, Diette GB. Mouse allergen-specific antibody responses in inner-city children with asthma. Journal of Allergy and Clinical Immunology 2007;119(4):910-915. |
R832139 (2007) R832139C001 (2007) |
Exit |
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Mudd KE, Bollinger ME, Hsu VD, Manning A, Tsoukleris MG, Butz AM. Concordance of Medicaid and pharmacy record data in inner-city children with asthma. Contemporary Clinical Trials 2008;29(1):13-20. |
R832139 (Final) R832139C002 (Final) |
Exit Exit |
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Mudd K, Bollinger ME, Hsu VD, Donithan M, Butz A. Pharmacy fill patterns in young urban children with persistent asthma. Journal of Asthma 2006;43(8):597-600. |
R832139 (2007) R832139C002 (2007) |
not available |
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Okelo SO, Wu AW, Krishnan JA, Rand CS, Skinner EA, Diette GB. Emotional quality-of-life and outcomes in adolescents with asthma. Journal of Pediatrics 2004;145(4):523-529. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C001 (2004) |
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Okelo SO, Wu AW, Merriman B, Krishnan JA, Diette GB. Are physician estimates of asthma severity less accurate in black than in white patients? Journal of General Internal Medicine 2007;22(7):976-981. |
R832139 (2007) R832139C001 (2007) |
Exit |
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Paasche-Orlow MK, Riekert KA, Bilderback A, Chanmugam A, Hill P, Rand CS, Brancati FL, Krishnan JA. Tailored education may reduce health literacy disparities in asthma self-management. American Journal of Respiratory and Critical Care Medicine 2005;172(8):980-986. |
R832139 (2006) |
Exit Exit |
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Perkins C, Wills-Karp M, Finkelman FD. IL-4 induces IL-13-independent allergic airway inflammation. Journal of Allergy and Clinical Immunology 2006;118(2):410-419. |
R832139 (Final) R832139C003 (2007) |
Exit Exit |
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Perry TT, Wood RA, Matsui EC, Curtin-Brosnan J, Rand C, Eggleston PA. Room-Specific Characteristics of Suburban Homes as Predictors of Indoor Allergen Concentrations. Annals of Allergy, Asthma & Immunology 2006;97(5):628-635. |
R832139 (2007) |
not available |
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Perry T, Matsui E, Merriman B, Duong T, Eggleston P. The prevalence of rat allergen in inner-city homes and its relationship to sensitization and asthma morbidity. Journal of Allergy and Clinical Immunology 2003;112(2):346-352. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C002 (2004) |
Exit |
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Phipatanakul W, Cronin B, Wood RA, Eggleston PA, Shih M-C, Song L, Tachdjian R, Oettgen HC. Effect of environmental intervention on mouse allergen levels in homes of inner-city Boston children with asthma. Annals of Allergy, Asthma & Immunology 2004:92(4):420-425. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C002 (2004) |
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Porter M, Karp M, Killedar S, Bauer SM, Guo J, Williams D, Breysse P, Georas SN, Williams MA. Diesel-enriched particulate matter functionally activates human dendritic cells. American Journal of Respiratory Cell and Molecular Biology 2007;37(6):706-719. |
R832139 (2007) |
not available |
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Rangasamy T, Guo J, Mitzner WA, Roman J, Singh A, Fryer AD, Yamamoto M, Kensler TW, Tuder RM, Georas SN, Biswal S. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. Journal of Experimental Medicine 2005;202(1):47-59. |
R832139 (2006) |
Exit Exit |
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Riekert KA, Butz AM, Eggleston PA, Huss K, Winkelstein M, Rand CS. Caregiver-physician medication concordance and undertreatment of asthma among inner-city children. Pediatrics 2003;111(3):e214-e220. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C002 (2004) |
Exit Exit |
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Rubenfeld J, Guo J, Sookrung N, Chen R, Chaicumpa W, Casolaro V, Zhao Y, Natarajan V, Georas S. Lysophosphatidic Acid Enhances Interleukin-13 Gene Expression and Promoter Activity in T Cells. Lung Cellular and Molecular Physiology 2006;290(1):L66-L74. |
R832139 (2007) |
not available |
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Rubinson L, Wu AW, Haponik EF, Diette GB. Why is it that internists do not follow guidelines for preventing intravascular catheter infections? Infection Control and Hospital Epidemiology 2005;26(6):525-533. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139 (2007) R832139 (Final) R832139C001 (2005) R832139C001 (2006) |
Exit Exit |
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Rule AM, Geyh AS, Ramos-Bonilla JP, Mihalic JN, Margulies JD, Polyak LM, Kesavan J, Breysse PN. Design and characterization of a sequential cyclone system for the collection of bulk particulate matter. Journal of Environmental Monitoring 2010;12(10):1807-1814. |
R832139 (Final) R832417 (Final) |
Exit |
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Saatian B, Zhao Y, He D, Georas SN, Watkins T, Spannhake EW, Natarajan V. Transcriptional Regulation of Lysophosphatidic Acid-Induced Interleukin-8 Expression and Secretion by p38 MAPK and JNK in Human Bronchial Epithelial Cells. Biochemical Journal 2006;393(3):657-668. |
R832139 (2007) |
not available |
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Sapkota A, Symons JM, Kleissl J, Wang L, Parlange MB, Ondov J, Breysse PN, Diette GB, Eggleston PA, Buckley TJ. Impact of the 2002 Canadian forest fires on particulate matter air quality in Baltimore city. Environmental Science & Technology 2005;39(1):24-32. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139 (2007) R832139 (Final) R832139C001 (2005) R832139C001 (2006) |
Exit Exit Exit |
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Saunders V, Breysse P, Clark J, Sproles A, Davila M, Wills-Karp M. Particulate matter-induced airway hyperresponsiveness is lymphocyte dependent. Environmental Health Perspectives 2010;118(5):640-646. |
R832139 (Final) R832139C003 (Final) |
Exit |
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Schmier JK, Manjunath R, Halpern MT, Jones ML, Thompson K, Diette GB. The impact of inadequately controlled asthma in urban children on quality of life and productivity. Annals of Allergy, Asthma & Immunology 2007;98(3):245-251. |
R832139 (2007) R832139C001 (2007) |
Exit |
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Schweitzer IB, Smith E, Harrison DJ, Myers DD, Eggleston PA, Stockwell JD, Paigen B, Smith AL. Reducing exposure to laboratory animal allergens. Comparative Medicine 2003;53(5):487-492. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C002 (2004) |
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Sharma HP, Hansel NN, Matsui EC, Diette GB, Eggleston PA, Breysee PN. Indoor environmental influences on children's asthma. Pediatric Clinics of North America 2007;54(1):103-120. |
R832139 (2007) R832139C001 (2007) |
Exit |
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Sharma HP, Matsui EC, Eggleston PA, Hansel NN, Curtin-Brosnan J, Diette GB. Does current asthma control predict future health care use among black preschool-aged inner-city children? Pediatrics 2007;120(5):e1174-1181. |
R832139 (Final) R832139C001 (Final) |
Exit Exit |
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Simons E, Curtin-Brosnan J, Buckley TJ, Breysse P, Eggleston PA. Indoor Environmental Differences between Inner City and Suburban Homes of Children with Asthma. Journal of Urban Health 2007;84(4):577-590. |
R832139 (2007) |
not available |
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Skinner EA, Diette GB, Algatt-Bergstrom PJ, Nguyen TT, Clark RD, Markson LE, Wu AW. The Asthma Therapy Assessment Questionnaire (ATAQ) for children and adolescents. Disease Management 2004;7(4):305-313. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C001 (2004) |
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Smith A, Krishnan JA, Bilderback A, Riekert KA, Rand CS, Bartlett SJ. Depressive symptoms and adherence to asthma therapy after hospital discharge. Chest 2006;130(4):1034-1038. |
R832139 (2007) |
not available |
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Swartz LJ, Callahan KA, Butz AM, Rand CS, Kanchanaraksa S, Diette GB, Krishnan JA, Breysse PN, Buckley TJ, Mosley AM, Eggleston PA. Methods and issues in conducting a community-based environmental randomized trial. Environmental Research 2004;95(2):156-165. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C001 (2004) |
Exit Exit |
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Walker J, Lewis-Land C, Kub J, Tsoukleris M, Butz A. The effect of violence on asthma:are our children facing a double-edged sword? Journal of Community Health 2008;33(6):384-388. |
R832139 (Final) R832139C002 (Final) |
Exit Exit |
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Williams MA, Porter M, Roman J, Breysse P, Williams D, Georas SN. Ambient Baltimore Particulate Matter Directs Non-Classical Immune Activation of Human Myeloid Dendritic Cells. Journal of Allergy and Clinical Immunology 2007;119(2):488-497. |
R832139 (2007) R832139C004 (2007) |
not available |
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Williams MA, Cheadle C, Watkins T, Killedar S, Tailor A, Barnes K, Georas S. TLR2 and TLR4 are potential biomarkers of environmental particulate matter exposed human myeloid dendritic cells. Biomarker Insights 2007;2:225-239. |
R832139C004 (2007) |
not available |
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Williams MA, Bauer S, Lu W, Guo J, Walter S, Bushnell TP, Lillehoj EP, Georas SN. Deletion of the mucin-like molecule muc1 enhances dendritic cell activation in response to toll-like receptor ligands. Journal of Innate Immunity 2010;2(2):123-143. |
R832139 (Final) R832139C004 (Final) |
Exit Exit |
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Williams MC, Georas S. Gene expression patterns and susceptibility to allergic responses. Expert Review of Clinical Immunology 2006;2(1):59-73. |
R832139 (2006) R832139 (2007) R832139C001 (2007) R832139C004 (2006) |
Exit |
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Wills-Karp M, Ewart SL. Time to draw breath: asthma-susceptibility genes are identified. Nature Reviews Genetics 2004;5(5):376-387. |
R832139 (2004) R832139 (2005) R832139C003 (2004) |
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Wills-Karp M, Koehl J. New insights into the role of the complement pathway in allergy and asthma. Current Allergy and Asthma Reports 2005;5(5):362-369. |
R832139 (2007) R832139C003 (2006) |
Exit |
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Wills-Karp M. Complement activation pathways: a bridge between innate and adaptive immune responses in asthma. Proceedings of the American Thoracic Society 2007;4:247-251. |
R832139C003 (2007) |
not available |
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Winkelstein ML, Quartey R, Pham L, Lewis-Boyer L, Lewis C, Hill K, Butz A. Asthma education for rural school nurses: resources, barriers, and outcomes. Journal of School Nursing 2006;22(3):170-177. |
R832139 (2007) R832139C002 (2006) R832139C002 (2007) |
Exit Exit Exit |
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Wolfenden LL, Diette GB, Krishnan JA, Skinner EA, Steinwachs DM, Wu AW. Lower physician estimate of underlying asthma severity leads to undertreatment. Archives of Internal Medicine 2003;163(2):231-236. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C001 (2004) |
Exit Exit |
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Yurk RA, Diette GB, Skinner EA, Dominici F, Clark RD, Steinwachs DM, Wu AW. Predicting patient-reported asthma outcomes for adults in managed care. The American Journal of Managed Care 2004;10(5):321-328. |
R832139 (2004) R832139 (2005) R832139 (2007) R832139C001 (2004) |
Exit Exit |
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Zambelli-Weiner A, Ehrlich E, Stockton ML, Grant AV, Zhang S, Levett PN, Beaty TH, Barnes KC. Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study. Journal of Allergy and Clinical Immunology 2005;115(6):1203-1209. |
R832139 (2006) |
Exit Exit Exit |
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Zeldin DC, Eggleston P, Chapman M, Piedimonte G, Renz H, Peden D. How exposures to biologics influence the induction and incidence of asthma. Environmental Health Perspectives 2006;114(4):620-626. |
R832139 (2004) R832139 (2005) R832139 (2006) R832139 (2007) R832139C001 (2007) R832139C002 (2005) R832139C003 (2005) |
Exit Exit |
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Zhao Y, He D, Zhao J, Wang L, Leff AR, Spannhake EW, Georas S, Natarajan V. Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells. Journal of Biological Chemistry 2007;282(14):10172-10179. |
R832139 (2007) |
not available |
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Tsou PY, McCormack MC, Matsui EC, Peng RD, Diette GB, Hansel NN, Davis MF. The effect of dog allergen exposure on asthma morbidity among inner‐city children with asthma. Pediatric Allergy and Immunology 2020;31(2):210-3. |
R832139 (Final) R834510 (Final) R836150 (2020) R836152 (Final) |
Exit |
Supplemental Keywords:
Health, Scientific Discipline, Geographic Area, HUMAN HEALTH, Health Risk Assessment, Epidemiology, State, Risk Assessments, Biochemistry, Health Effects, asthma, children's health, particulate matter, adolescents, morbidity, airway disease, allergic airway disease, ozone, respiratory disease, air pollution, asthmatic children, human exposure, Maryland (MD), cigarette smoke, environmental tobacco smoke, urban environment, airborne urban contaminantsProgress and Final Reports:
Original Abstract Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832139C001 The Epidemiology of Susceptibility to Airborne Particulates and Allergens to Asthma in African Americans
R832139C002 A Randomized Controlled Trial of Behavior Changes in Home Exposure Control
R832139C003 Mechanisms of Particulate-Induced Allergic Asthma
R832139C004 Dendritic Cell Activation by Particulate Matter and Allergen
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2009
- 2008
- 2007 Progress Report
- 2005 Progress Report
- 2004 Progress Report
- Original Abstract
113 journal articles for this center