Grantee Research Project Results
2007 Progress Report: Current-Use Pesticides: Assessing Exposure and Spermatoxicity
EPA Grant Number: R832515 aka R832098Title: Current-Use Pesticides: Assessing Exposure and Spermatoxicity
Investigators: Swan, Shanna Helen
Current Investigators: Swan, Shanna Helen , Thomas, Peter , Sparks, Amy
Institution: University of Rochester
Current Institution: The University of Texas at Austin , University of Iowa , University of Rochester
EPA Project Officer: Klieforth, Barbara I
Project Period: September 1, 2005 through August 31, 2010
Project Period Covered by this Report: September 1, 2006 through August 31, 2007
Project Amount: $672,821
RFA: Application of Biomarkers to Environmental Health and Risk Assessment (2004) RFA Text | Recipients Lists
Research Category: Hazardous Waste/Remediation , Human Health
Objective:
Primary objectives:
- Increase the precision of our prior estimates of exposure to current-use pesticides and compare these in agricultural (IA and MO) and urban (MN) areas;
- Estimate the strength of the associations between biomarkers of current-use pesticides and semen parameters across our three study centers, as well as within center;
Secondary objectives:
- Examine correlation between the man’s and the woman’s biomarker levels of current-use pesticides as well as geographical clustering of exposure levels;
- Examine the effects of simultaneous exposure to multiple pesticides on semen quality and compare the fit of additive, sub-additive and super-additive models to these data;
- Measure associations between urinary and serum biomarkers of current-use pesticides;
- Measure levels of human sperm membrane progesterone receptor (hmPRα) in relation to both semen parameters and levels of current-use pesticides.
Progress Summary:
Year 2 Progress and Accomplishments:
- In the second study year we continued data cleaning and coding completed data entry, cleaning and documenting all SAS data sets fro the Study for Future Families, which are essential for the analyses to be conducted under this STAR award.
- While the 589 stored urine samples from SFF adult participants to be analyzed for pesticide metabolites as well as creatinine and specific gravity had been shipped to CDC, due to the backlog in the pesticide lab, CDC was not able to run these analyses in this study year.
- Therefore, we conducted analyses on several factors potentially related to related to semen quality. By identifying additional risk factors for impaired semen quality, we will be able to control for these in our analysis of pesticides and semen quality, thus increasing the power of that study to identify effects of pesticide exposure. These analyses (and citations if published) are listed below.
Future Activities:
We have a commitment from Dana Barr at the Pesticides Lab in CDC to analyze 300 male samples in the first 3 months of 2008. We have a commitment from Antonia Calafat to analyze 300 samples for BPA in the same time period. Therefore we expect to:
- Obtain urinary metabolites of 15 pesticide metabolites in 300 men from MO, MN and IA for whom we have measured phthalates, semen parameters and hormone levels.
- Analyze the relationships between these pesticide concentrations and sperm concentration, motility and morphology and prepare a manuscript on this topic.
- Obtain urinary metabolites of bisphenol-A (BPA) in the same 300 men from MO, MN and IA for whom we have measured phthalates, semen parameters and hormone levels
- Analyze the relationships between BPA concentration and sperm concentration, motility and morphology and prepare a manuscript on this topic.
- Develop Bayesian methods using structural equation modeling to examine the effects on semen quality of exposure to mixtures of these chemicals.
- Examine associations between pesticide concentration as well as BPA concentration on hmPRα in 77 IA men and prepare a manuscript on this topic.
Journal Articles on this Report : 5 Displayed | Download in RIS Format
Other project views: | All 13 publications | 12 publications in selected types | All 9 journal articles |
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Cooper TG, Brazil C, Swan SH, Overstreet JW. Ejaculate volume is seriously underestimated when semen is pipetted or decanted into cylinders from the collection vessel. Journal of Andrology 2007;28(1):1-4. |
R832515 aka R832098 (2007) R832515 aka R832098 (2008) |
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Gollenberg AL, Liu F, Brazil C, Drobnis EZ, Guzick D, Overstreet JW, Redmon JB, Sparks A, Wang C, Swan SH. Semen quality in fertile men in relation to psychosocial stress. Fertility and Sterility 2010;93(4):1104-1111. |
R832515 aka R832098 (2007) R832515 aka R832098 (2008) |
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Stokes-Riner A, Thurston SW, Brazil C, Guzick D, Liu F, Overstreet JW, Wang C, Sparks A, Redmon JB, Swan SH. One semen sample or two? Insights from a study of fertile men. Journal of Andrology 2007;28(5):638-643. |
R832515 aka R832098 (2006) R832515 aka R832098 (2007) R832515 aka R832098 (2008) R832515 aka R832098 (Final) |
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Swan SH, Liu F, Overstreet JW, Brazil C, Skakkebaek NE. Semen quality of fertile US males in relation to their mothers' beef consumption during pregnancy. Human Reproduction 2007;22(6):1497-1502. |
R832515 aka R832098 (2007) R832515 aka R832098 (2008) |
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Swan SH, Liu F, Overstreet JW, Brazil C, Skakkebaek NE. Reply: testis development, beef consumption and study methods. Human Reproduction 2007;22(9):2574-2575 (letter to the editor). |
R832515 aka R832098 (2007) R832515 aka R832098 (2008) |
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Supplemental Keywords:
semen quality, pesticides, atrazine, bisphenol-A, mixtures, fertility,, RFA, Health, Scientific Discipline, Health Risk Assessment, Endocrine Disruptors - Environmental Exposure & Risk, endocrine disruptors, Biochemistry, Endocrine Disruptors - Human Health, pesticide exposure, altered sexual development, EDCs, endocrine disrupting chemicals, exposure studies, developmental biology, human growth and development, atrazine, agrochemicalsRelevant Websites:
http://www.urmc.rochester.edu/obgyn/sff Exit (User ID: sff; password: family1)
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.