Grantee Research Project Results
2006 Progress Report: Current-Use Pesticides: Assessing Exposure and Spermatoxicity
EPA Grant Number: R832515 aka R832098Title: Current-Use Pesticides: Assessing Exposure and Spermatoxicity
Investigators: Swan, Shanna Helen , Thomas, Peter , Sparks, Amy
Institution: University of Rochester , The University of Texas at Austin , University of Iowa
Current Institution: The University of Texas at Austin , University of Iowa , University of Rochester
EPA Project Officer: Klieforth, Barbara I
Project Period: September 1, 2005 through August 31, 2010
Project Period Covered by this Report: September 1, 2005 through August 31,2006
Project Amount: $672,821
RFA: Application of Biomarkers to Environmental Health and Risk Assessment (2004) RFA Text | Recipients Lists
Research Category: Hazardous Waste/Remediation , Human Health
Objective:
Prior to this grant we had found, in our multicenter study of semen quality (Study for Future Families), significant geographic variation in semen quality that could not be attributed to confounding or methodological differences between centers. We looked for environmental factors that might explain the differences in semen quality between our most rural center (Mid-Missouri, MO) and an urban center (Minneapolis, MN). Using a small sample and a nested case-control study design we found that urinary metabolites of several current-use pesticides were significantly related to semen quality in a nested case-control study of men in MO. This study was published in 2003 and provided the rationale for the study funded by EPA Grant Number: RD832515, entitled Current-use pesticides: Assessing exposure and spermatoxicity.
Initial Objectives:
In this STAR grant we proposed to examine associations between current use pesticides and semen quality by conducting additional testing in MO and MN men and extending this analysis to Iowa men.
Revised objectives to including and BPA analyses and structural equation modeling:
Due to CDCs heavy workload there were several years of delay in obtaining pesticide results. (See annual reports). We therefore applied for and received permission from EPA (December 2007) to use some of the funds for other analyses. The extended aims included estimating the strength of the associations between biomarkers of BPA and semen parameters, as well as developing statistical methods for examining multiple samples per man, and examining effects of joint exposure to multiple chemicals (such as BPA and pesticides).
Progress Summary:
Journal Articles on this Report : 2 Displayed | Download in RIS Format
Other project views: | All 13 publications | 12 publications in selected types | All 9 journal articles |
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Type | Citation | ||
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Mendiola J, Jorgensen N, Andersson AM, Calafat AM, Ye X, Redmon JB, Drobnis EZ, Wang C, Sparks A, Thurston SW, Liu F, Swan SH. Are environmental levels of bisphenol A associated with reproductive function in fertile men? Environmental Health Perspectives 2010;118(9):1286-1291. |
R832515 aka R832098 (2006) R832515 aka R832098 (Final) |
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Stokes-Riner A, Thurston SW, Brazil C, Guzick D, Liu F, Overstreet JW, Wang C, Sparks A, Redmon JB, Swan SH. One semen sample or two? Insights from a study of fertile men. Journal of Andrology 2007;28(5):638-643. |
R832515 aka R832098 (2006) R832515 aka R832098 (2007) R832515 aka R832098 (2008) R832515 aka R832098 (Final) |
Exit Exit Exit |
Supplemental Keywords:
BPA, semen quality, hmPRα density, serum hormones, latent variable model, RFA, Health, Scientific Discipline, Health Risk Assessment, Endocrine Disruptors - Environmental Exposure & Risk, endocrine disruptors, Biochemistry, Endocrine Disruptors - Human Health, pesticide exposure, altered sexual development, EDCs, endocrine disrupting chemicals, exposure studies, developmental biology, human growth and development, atrazine, agrochemicalsProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.