Grantee Research Project Results

1999 Progress Report: Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality

EPA Grant Number: R827355C001
Subproject: this is subproject number 001 , established and managed by the Center Director under grant R827355
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Center for Air, Climate, and Energy Solutions
Center Director: Robinson, Allen
Title: Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Koenig, Jane Q. , Siscovick, David , Checkoway, Harvey
Current Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Karr, Catharine J. , Schreuder, Astrid , Siscovick, David , Sullivan, Jeff , Shepherd, Kristine , Miller, Kristine , Ishikawa, Naomi
Institution: University of Washington
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2004 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 1999 through May 31, 2000
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Particulate Matter , Air Quality and Air Toxics , Air

Objective:

This project consists of two related study designs addressing associations between ambient PM exposure and cardiorespiratory disease risks. The first is a time-series analysis of cause-specific mortality in Seattle that relates daily mortality with changes in PM and co-pollutant levels. Its emphasis is cardiovascular and respiratory disease mortality. In parallel with this analysis, we also are performing similar time-series analyses of mortality in Spokane, Washington, and Anchorage, Alaska. The contrasts of results between Seattle, Spokane, and Anchorage, which have different PM compositions, should add significant new information about the relative contributions of particle count, size, and chemical composition to cardiorespiratory mortality. The second design is a "case-crossover" study of roughly 1,100 out-of-hospital sudden cardiac arrest (SCA) cases in Seattle. This design compares PM levels in the days immediately preceding SCA events with levels at previous reference time points.

Progress Summary:

The relationship between sudden cardiac death in King County with daily air pollution was evaluated. The title of this project is "A Case Cross-Over Study of Particulate Matter Air Pollution and Out-of Hospital Primary Cardiac Arrest in King County, Washington." There were 362 cases. This analysis did not find an association between any PM parameters and sudden cardiac death. One possible explanation is that the cases were highly selected and not very susceptible. Three additional analyses relating to the cases-crossover study were undertaken as part of the EPA PM Center and/or the National Research Center for Statistics and the Environment at the University of Washington.

Future Activities:

Project 1 plans to extend this analysis to a new cohort of sudden cardiac death cases totaling more than 1,000 individuals. To assess the role of susceptibility, Project 1 investigators also plan to conduct similar case-crossover analyses of asthma, respiratory diseases, and other cardiovascular endpoints. An effort will be made to use data from personal exposure assessments from Project 2 to reduce exposure error.

Journal Articles on this Report : 1 Displayed | Download in RIS Format

Publications Views
Other subproject views:	All 21 publications	14 publications in selected types	All 14 journal articles
Other center views:	All 209 publications	113 publications in selected types	All 109 journal articles

Publications
Type	Citation	Sub Project	Document Sources
Journal Article	Sheppard L, Kaufman J. Sorting out the role of air pollutants in asthma initiation. Epidemiology 2000;11(2):100-101.	R827355 (2004) R827355 (Final) R827355C001 (1999) R827355C001 (2001) R827355C009 (Final)	Abstract from PubMed Abstract: LWW-Abstract and Full Text HTML Exit

Supplemental Keywords:

ambient particles, fine particles, combustion, health, exposure, biostatistics, susceptibility., RFA, Health, Scientific Discipline, Air, PHYSICAL ASPECTS, Geographic Area, Susceptibility/Sensitive Population/Genetic Susceptibility, Health Risk Assessment, Physical Processes, Risk Assessments, State, particulate matter, genetic susceptability, Environmental Chemistry, Incineration/Combustion, Epidemiology, Allergens/Asthma, Children's Health, indoor air, Northwest, Atmospheric Sciences, Biochemistry, Toxicology, air toxics, aerosols, health effects, Human Health Risk Assessment, health risks, incineration, environmental hazard exposures, California (CA), air quality, hazardous air pollutants, hydrocarbons, combustion contaminants, epidemeology, indoor air quality, sensitive populations, epidemelogy, biological markers, allergen, asthma, airway inflammation, harmful environmental agents, ambient aerosol, combustion emissions, indoor environment, atmospheric chemistry, risk assessment, mortality, biological response, human exposure, combustion, animal model, PAHs, morbidity, cardiopulmonary responses, children, particulates, ambient particle health effects, allergens, exposure, air pollutants, toxics, atmospheric aerosols, biostatistics, particle transport, children's vulnerablity, ambient air, airborne pollutants, air pollution, ambient air quality, cardiovascular disease, human health risk, assessment of exposure, human health effects, human susceptibility, acute cardiovascular effects, exposure assessment, exposure and effects, particle exposure, mortality studies, cardiopulmonary response, airway disease

Relevant Websites:

http://depts.washington.edu/pmcenter/ Exit EPA icon

Progress and Final Reports:

Original Abstract

Main Center Abstract and Reports:

R827355 Center for Air, Climate, and Energy Solutions

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827355C001 Epidemiologic Study of Particulate Matter and Cardiopulmonary Mortality
R827355C002 Health Effects
R827355C003 Personal PM Exposure Assessment
R827355C004 Characterization of Fine Particulate Matter
R827355C005 Mechanisms of Toxicity of Particulate Matter Using Transgenic Mouse Strains
R827355C006 Toxicology Project -- Controlled Exposure Facility
R827355C007 Health Effects Research Core
R827355C008 Exposure Core
R827355C009 Statistics and Data Core
R827355C010 Biomarker Core
R827355C011 Oxidation Stress Makers

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.