Grantee Research Project Results

Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures

EPA Grant Number: R827353C010
Subproject: this is subproject number 010 , established and managed by the Center Director under grant R827353
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Health Effects Institute (2015 - 2020)
Center Director: Greenbaum, Daniel S.
Title: Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
Investigators: Speizer, Frank E.
Current Investigators: Speizer, Frank E. , Park, S.
Institution: Harvard University
EPA Project Officer: Chung, Serena
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Amount: Refer to main center abstract for funding details.
RFA: Airborne Particulate Matter (PM) Centers (1999) RFA Text | Recipients Lists
Research Category: Particulate Matter , Air Quality and Air Toxics , Air

Objective:

This project is one of three under Theme III: Biological Mechanisms and Dosimetry of our proposal. The main objective of this project is to investigate associations of selected inflammatory and blood clotting parameters in free living humans with particle and criteria gas exposures.

Theme III includes three projects which aim to identify the particulate and gaseous air pollutants responsible for increased cardiac vulnerability and to define the biological mechanisms that lead to this outcome. Projects IIIa and IIIb are both based on a dog model of coronary occlusion and controlled exposures to concentrated ambient particles. Project IIIa will use this model and technology to explore the role of particle size (coarse, fine, and ultra fine), particle composition (metals, ions, and carbon), and criteria gases (O3, NO2, CO, and SO2) on cardiac and respiratory health. Project IIIa will also use pharmacological intervention to explore biological mechanisms by which particles accelerate and increase sensitivity to the ischemic response, examining both autonomic nervous system and inflammatory mechanisms. Project IIIb will determine in-situ particle doses during the inhalation studies using online measurements of particle number and size in the inhaled and exhaled air. This will enable us to provide a better interpretation of the observed outcomes and to examine the role of particle composition, gaseous co-pollutants, and susceptibility on particle deposition. The third project, Project IIIc, is a human panel study, which will be performed concurrent with our animal inhalation projects. Project IIIc will investigate the effects of particle mass, composition, and gaseous co-pollutants on blood viscosity, other clotting parameters, and cardiac health of individuals living in the Boston Metropolitan area. Results from this project will be integrated with results from animal inhalation studies to improve our understanding of the role of particle composition and gaseous co-pollutants on cardiovascular health and of the biological mechanisms leading to the adverse effects.

Publications and Presentations:

Publications have been submitted on this subproject: View all 6 publications for this subproject | View all 207 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 6 journal articles for this subproject | View all 204 journal articles for this center

Supplemental Keywords:

particulate matter, PM2.5, PM10, air pollutants, particulates, health effects, exposure, ambient particles, susceptibility, metals, public policy, biology, engineering, epidemiology, toxicology, environmental chemistry, monitoring., Health, RFA, Air, Scientific Discipline, Geographic Area, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessments, State, particulate matter, Biology, Environmental Chemistry, Epidemiology, Molecular Biology/Genetics, Atmospheric Sciences, Disease & Cumulative Effects, Toxicology, air toxics, Environmental Engineering, Environmental Monitoring, epidemelogy, respiratory disease, cardiac ischemia, air quality, health risks, Human Health Risk Assessment, indoor air quality, sensitive populations, health effects, human health, inhaled, particle size, biological mechanism , pulmonary disease, cardiac arrhythmia, particle chemical composition, ambient air monitoring, elderly, blood viscosity, respiratory, gaseous co-polutants, risk assessment, lung cancer, human exposure, automotive emissions, genetic susceptibility, chemical exposure, chronic effects, particulate exposure, cardiopulmonary responses, dosimetry, pulmonary, monitoring, developmental effects, ambient particle health effects, exposure, children, cardiopulmonery responses, particulates, PM, inhalation toxicology, inhaled particles, molecular epidemiology, heart rate, air pollutants, ambient air, toxics, atmospheric particulate matter, air pollution, cardiovascular disease, human health risk, ambient air quality, human health effects, human susceptibility, cardiopulmonary, metals, traffic related air pollution, Massachusetts (MA), particle exposure, cardiopulmonary response, interindividual variability, inhalation, ambient measurement methods

Progress and Final Reports:

Main Center Abstract and Reports:

R827353 Health Effects Institute (2015 - 2020)

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827353C001 Assessing Human Exposures to Particulate and Gaseous Air Pollutants
R827353C002 Quantifying Exposure Error and its Effect on Epidemiological Studies
R827353C003 St. Louis Bus, Steubenville and Atlanta Studies
R827353C004 Examining Conditions That Predispose Towards Acute Adverse Effects of Particulate Exposures
R827353C005 Assessing Life-Shortening Associated with Exposure to Particulate Matter
R827353C006 Investigating Chronic Effects of Exposure to Particulate Matter
R827353C007 Determining the Effects of Particle Characteristics on Respiratory Health of Children
R827353C008 Differentiating the Roles of Particle Size, Particle Composition, and Gaseous Co-Pollutants on Cardiac Ischemia
R827353C009 Assessing Deposition of Ambient Particles in the Lung
R827353C010 Relating Changes in Blood Viscosity, Other Clotting Parameters, Heart Rate, and Heart Rate Variability to Particulate and Criteria Gas Exposures
R827353C011 Studies of Oxidant Mechanisms
R827353C012 Modeling Relationships Between Mobile Source Particle Emissions and Population Exposures
R827353C013 Toxicological Evaluation of Realistic Emissions of Source Aerosols (TERESA) Study
R827353C014 Identifying the Physical and Chemical Properties of Particulate Matter Responsible for the Observed Adverse Health Effects
R827353C015 Research Coordination Core
R827353C016 Analytical and Facilities Core
R827353C017 Technology Development and Transfer Core

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.