Grantee Research Project Results
2023 Progress Report: INnovations to generate estimates of childrens soil/dust inTake (INGEST)
EPA Grant Number: R840200Title: INnovations to generate estimates of childrens soil/dust inTake (INGEST)
Investigators: Nachman, Keeve , Woodruff, Tracey J. , Davis, Meghan , Prasse, Carsten , Quirós-Alcalá, Lesliam , Voegtline, Kristin , Yuille, Alan , Lupolt, Sara
Current Investigators: Nachman, Keeve , Woodruff, Tracey J. , Davis, Meghan , Prasse, Carsten , Quirós-Alcalá, Lesliam , Voegtline, Kristin , Yuille, Alan
Institution: Johns Hopkins University , University of California - San Francisco
EPA Project Officer: Hahn, Intaek
Project Period: August 1, 2021 through June 30, 2024 (Extended to June 30, 2026)
Project Period Covered by this Report: August 1, 2022 through July 31,2023
Project Amount: $1,350,000
RFA: Estimating Childrens Soil and Dust Ingestion Rates for Exposure Science (2020) RFA Text | Recipients Lists
Research Category: Children's Health , Endocrine Disruptors , Human Health
Objective:
We propose an integrated and highly innovative portfolio of tools and approaches to assess dust and soil exposures for children ages six months to six years via macro-and micro-activity pattern and tracer studies. The objectives are to 1) longitudinally characterize lifestage and developmental milestone-specific macro-activity and microenvironmental patterns for children ages six months – six years; 2) prospectively collect and analyze in-home macro-activity video footage to describe the environmental and human factors that modify micro-activity patterns for children ages six – eighteen months; and 3) identify organic chemical fingerprints in three environmental and two biological samples using non-targeted analytical approaches to propose novel organic candidate tracer compounds and tracer mixtures for estimation of children’s soil and dust intake.
Progress Summary:
IRB approval has been secured for all aims (including modifications), and all data and sample collection protocols have been finalized. Participant recruitment for all three project objectives is underway. For the first objective, we have successfully collected the Summer season of time-activity using smartphone surveys and have begun the fall collection; for the Baltimore cohort, we are entering into the second season of collection, and we are initiating collection for our San Francisco cohort. For the second objective, we are actively recruiting and conducting home visits to collect videography data. The computer vision and behavioral coding methods for quantifying microactivities are in active development. For the third objective, method development is complete and recruitment and sample collection has begun; non-target analytical data are being generated and initial phases of organic tracer work are underway. The goals of the project have not changed from the original application, and that no delays have occurred that will materially impair our ability to meet the results specified in the application.
Future Activities:
Immediate-term activities include continuation of participant recruitment and data/sample for all three objectives. Concurrently, we will conduct exploratory/initial data analyses to assess progress, and further develop the computer vision methodology for microactivity assessment to include consideration of pacifier/comfort object use and “rewetting” behaviors. We will continue to process the results of our multi-media non-target analytical data to begin consideration of candidates for tracer development.
Journal Articles on this Report : 1 Displayed | Download in RIS Format
| Other project views: | All 7 publications | 2 publications in selected types | All 2 journal articles |
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Lupolt SN, Newmeyer MN, Lyu Q, Prasse C, Nachman KE. Optimization of a method for collecting infant and toddler urine for non-target analysis using cotton pads and commercially available disposable diapers. Journal of Exposure Science & Environmental Epidemiology 2023:1-8. |
R840200 (2023) |
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Supplemental Keywords:
sensitive populations; human health; survey; measurement methods; observationRelevant Websites:
The INnovations to Generate Estimates of children's Soil/dust inTake (INGEST) Study Exit
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.