Grantee Research Project Results
2022 Progress Report: INnovations to generate estimates of childrens soil/dust inTake (INGEST)
EPA Grant Number: R840200Title: INnovations to generate estimates of childrens soil/dust inTake (INGEST)
Investigators: Nachman, Keeve , Woodruff, Tracey J. , Davis, Meghan , Prasse, Carsten , Quirós-Alcalá, Lesliam , Voegtline, Kristin , Yuille, Alan
Current Investigators: Nachman, Keeve , Woodruff, Tracey J. , Davis, Meghan , Prasse, Carsten , Quirós-Alcalá, Lesliam , Voegtline, Kristin , Yuille, Alan , Lupolt, Sara
Institution: Johns Hopkins University , University of California - San Francisco
EPA Project Officer: Hahn, Intaek
Project Period: August 1, 2021 through June 30, 2024 (Extended to June 30, 2025)
Project Period Covered by this Report: August 1, 2021 through July 31,2022
Project Amount: $1,350,000
RFA: Estimating Childrens Soil and Dust Ingestion Rates for Exposure Science (2020) RFA Text | Recipients Lists
Research Category: Human Health , Children's Health
Objective:
We propose an integrated and highly innovative portfolio of tools and approaches to assess dust and soil exposures for children ages six months to six years via macro-and micro-activity pattern and tracer studies. The objectives are to 1) longitudinally characterize lifestage and developmental milestone-specific macro-activity and microenvironmental patterns for children ages six months – six years; 2) prospectively collect and analyze in-home macro-activity video footage to describe the environmental and human factors that modify micro-activity patterns for children ages six – eighteen months; and 3) identify organic chemical fingerprints in three environmental and two biological samples using non-targeted analytical approaches to propose novel organic candidate tracer compounds and tracer mixtures for estimation of children’s soil and dust intake.
Progress Summary:
Our effort in this initial performance period has been focused on method development and pilot testing. To date, using IRB-approved pilot methodologies, we have developed and tested methods for our Time Activity Assessment (Objective 1), videography (Objective 2), and for collection of individual environmental and biological media involved in the development of novel organic tracers (Objective 3). Following IRB re-assessment of our revised methods, we plan to finalize our data and sample collection protocols in the coming months and begin participant recruitment in our Baltimore and San Francisco cohorts. The goals of the project have not changed from the original application, and that no delays have occurred that will materially impair our ability to meet the results specified in the application.
Future Activities:
Immediate term activities include finalization of protocols, IRB re-approval, and initiation of recruitment for all objectives. Training will begin for human coders/validators of our computer vision methods, and the methodology for video curation and vision-based microactivity assessment will be refined and finalized. At this point, full recruitment and data/sample collection will begin in earnest.
Journal Articles:
No journal articles submitted with this report: View all 5 publications for this projectSupplemental Keywords:
sensitive populations; human health; survey; measurement methods; observationProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.