Grantee Research Project Results
2022 Progress Report: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air):Next Stage
EPA Grant Number: R838300Title: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air):Next Stage
Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Kronmal, Richard , Barr, R. Graham , Burke, Gregory L. , Jacobs, David , Folsom, Aaron , Liu, Kiang J. , Sampson, Paul , Watson, Karol , Szpiro, Adam , Post, Wendy , Allen, Norrina , Pankow, James F.
Current Investigators: Kaufman, Joel D. , Sheppard, Lianne (Elizabeth) A. , Kronmal, Richard , Barr, R. Graham , Burke, Gregory L. , Jacobs, David , Folsom, Aaron , Liu, Kiang J. , Sampson, Paul , Watson, Karol , Szpiro, Adam , Post, Wendy
Institution: University of Washington , Columbia University in the City of New York , Northwestern University , University of California - Los Angeles , Wake Forest University , University of Minnesota , The Johns Hopkins University
EPA Project Officer: Callan, Richard
Project Period: September 1, 2017 through August 31, 2021 (Extended to August 31, 2023)
Project Period Covered by this Report: September 1, 2021 through August 31,2022
Project Amount: $2,996,426
RFA: Long-term Exposure to Air Pollution and Development of Cardiovascular Disease (2016) RFA Text | Recipients Lists
Research Category: Air , Human Health , Airborne Particulate Matter Health Effects , Environmental Justice
Objective:
The aims for this project are unchanged from the original application. Our aims are: 1. To evaluate the relationship between individual-level long-term exposures to ambient air pollutants and the incidence of clinical CVD disease in the entire MESA Air cohort; 2. To characterize the relationships among individual-level long-term exposures to air pollutants and sub-clinical evidence of cardiovascular dysfunction and its sequelae, including progression of atherosclerosis, as determined by coronary artery calcium (CAC) measurements, cardiac structure and function by MRI and echocardiography, microvascular remodeling, and cerebrovascular consequences of atrial fibrillation; and 3. To quantify the impact of exposure measurement error (and role of increased model complexity and improved data quality) on health effect estimation and bias.
Progress Summary:
Progress in year 5 was as anticipated with air pollution modeling updates and progress on health analyses. Follow-up calls for events ascertainment for MESA Air New Recruit participants and MESA Family participants recruited into MESA Air concluded in year 4. Significant work has been done to adjudicate identified events from these follow-up calls, prioritizing older events first. In addition to the events surveillance and adjudication work, we have made considerable progress on novel modeling approaches. A daily high-resolution spatiotemporal daily carbon monoxide (CO) model developed for Baltimore using both regulatory measurements at agency monitoring sites and measurements from low-cost gas monitors deployed by our team has been published in Environmental Health Perspectives. We have also worked to improve the predictive performance of and extend our historical PM2.5 model resulting in improved predictions for the period between 1980 and 2019. Our efforts to more accurately model fine near-roadway concentration gradients for traffic-related air pollutants continued; we incorporated RLINE estimates as a spatial covariate in an LA NO2 model and found that integrating RLINE improved model performance. We have also developed national biweekly models for four PM2.5 species. We have continued to make updates to our database and modeling infrastructure. On the health analysis side, we finalized the primary results of the cardiac events analysis and are in the process of finalizing a manuscript for that key health analysis. We have published work investigating the impact of air pollution on child behavior, child blood pressure, cognitive decline, depression, and biomarkers of inflammation. A number of additional epidemiological analyses are underway including work on air pollution and cardiac structure and function. Finally, we are also continuing our work on data sharing by refining our plans to release additional de-identified data as part of the NIH/NHLBI BioLINCC.
Future Activities:
Throughout the next year, events adjudication will continue. The University of Washington team will continue to work on modeling efforts including finalizing the enhancements to the national historical PM2.5 model, extending the PM2.5 species model, and continuing the improvements to our MESA city exposure models with a focus on improving near-road exposure prediction. Our team will continue to work on health analyses, including finalizing the events analysis and an analysis of the relationship between exposure to air pollution and left ventricular structure and function. We will also continue to address the data sharing aspects of the project.
Journal Articles:
No journal articles submitted with this report: View all 61 publications for this projectSupplemental Keywords:
Ambient air, human health, particulates, epidemiology, ozone, traffic-related air pollution, exposure modeling, spatio-temporalRelevant Websites:
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2021 Progress Report
- 2020 Progress Report
- 2019 Progress Report
- 2018 Progress Report
- Original Abstract
55 journal articles for this project