Grantee Research Project Results
2016 Progress Report: Southern California Children's Environmental Health Center
EPA Grant Number: R835441Center: Southern California Children's Environmental Health Center
Center Director: McConnell, Rob Scot
Title: Southern California Children's Environmental Health Center
Investigators: McConnell, Rob Scot , Gilliland, Frank D. , Finch, Caleb E , Bouret, Sebastien G. , Hricko, Andrea M. , Sattler, Fred R , Nayak, Krishna S. , Sioutas, Constantinos , Allayee, Hooman , Johnston, Jill , Berhane, Kiros , Goran, Michael , Mittelman, Steven , Morgan, Todd
Current Investigators: McConnell, Rob Scot
Institution: University of Southern California
EPA Project Officer: Hahn, Intaek
Project Period: July 1, 2013 through June 30, 2018 (Extended to June 30, 2019)
Project Period Covered by this Report: July 1, 2015 through June 30,2016
Project Amount: $4,146,875
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2012) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
Project 1: Effects of Air Pollution on the Development of Obesity in Children
Aim 1 will investigate the longitudinal effects of prenatal, early and later childhood exposure traffic-related air pollutant on body mass index (BMI) trajectory and obesity in the CHS cohort. We hypothesize that elevated exposure traffic-related air pollutant during the in utero and childhood periods are obesogenic and result in a steeper gender-specific trajectory of BMI increase with age and that cumulative exposures increase the prevalence of obesity at ages 5, 10 and 16 years.
Project 2: Near-Roadway Air Pollution, Adipose Inflammation, and Metabolic Consequences
Aim 1: To investigate the effects of lifetime cumulative exposure to ambient near-roadway air pollution (NRAP) elemental carbon (EC) and NOx on macrophage polarization in deep SAT from M2 to pro-inflammatory M1 subtypes. We hypothesize that exposure to markers of the NRAP mixture [EC and oxides of nitrogen (NOx)] will be associated with increased proportion of M1/M2 macrophages and with the presence of clusters of nectoric macrophates [crown like structures (CLS)] in biopsy samples obtained from a novel deep subcutaneous adipost tissue (dSAT) biopsy.
Aim 2: To investigate the effects of lifetime exposure to NRAP on adipose tissue function and cell-specific gene expression. We hypothesize that high lifetime exposure to EC and NOx will be associated with (Aim 2a) increased expression of NFĸB inflammatory and insulin signaling pathway genes in macrophages and adipocyte subfractions of SAT, and (Aim 2b) greater release of adipocytokines and biochemical markers of insulin resistance from SAT biopsies incubated ex vivo.
Project 3: Longitudinal Effects of Air Pollution on Obesity In Mice
Aim 1: We will determine the longitudinal effects of nanoscale particulate matter (nPM) exposure on the development of obesity and relevant physiological metabolic phenotypes. Mice in the control and exposed groups will undergo magnetic resonance imaging (MRI) to determine body composition (lean tissue mass and whole body fat) and fat distribution. We will also perform intraperitoneal glucose tolerance tests (IPGTTs) to assess glucose/insulin metabolism, measure a panel of adipocytokines in plasma, and determine hepatic lipid content.
Community Outreach and Translation Core
Progress Summary:
All three projects have made substantial progress toward addressing Center goals. Recruitment of subjects is still ongoing for Projects 1 and 2. The first set of animal studies has been completed for P3 and results showing effects of air pollution on metabolic outcomes are summarized in a manuscript ready for submission. A followup experiment is underway to further characterize effects. The COTC has deepened working relationships with community counterparts and is actively engaged in providing the best information based on emerging science to outreach and translational activities. Additional details are provided in the individual project and core reports.
Project 1: Effects of Air Pollution on the Development of Obesity in Children
We have refined procedures for collecting tissue and for assays. Cell sorting is done at the time of adipose tissue biopsy and we have successfully counted M1 and M2 macrophages. We have in addition counted Treg and Teff cells. Tissue for other assays is archived until data collection is completed. Results to date demonstrate broad distribution both of outcomes and lifetime exposure. Recruitment continues to be slower than anticipated in part because it is dependent on the recruitment from Project 1. Some issues with staff turnover have been resolved and a new recruitment mechanism better coordinated with P1 has been implemented. As Project 1 recruitment has increased, recruitment in Project 2 has also increased. More appropriate compensation for time and travel reimbursement also have increased recruitment. In addition, with advice from members of our external advisory committee, we have explored several additional approaches to recruitment, including targeting the study demographic and residence requirements in study zip codes through commercial listings obtained from InfoUSA and Scientific Telephone Survey, and we have settled on methods previously developed by Center Deputy Director and P2 co-investigator Michael Goran to recruit through advertising, targeting the communities where Children’s Health Study subjects live and restricting recruitment to lifetime southern California residents willing to have a fat biopsy. We anticipate this will maximize the exposure contrast (based on exposure-stratified sampling procedures developed in P1) in the appropriate age range, will provide complementary data to that we are continuing to recruit from the P1 pool, and will allow us sufficient sample size to complete all major goals. We will conduct sensitivity analyses using the participants recruited through P1. We anticipate we will be able to catch up and complete recruitment on the original time table within the next 12 months.
Project 3: Longitudinal Effects of Air Pollution on Obesity in Mice
During year 2 of the project, we first determined the effects of NRAP on obesity in mice that had whole life exposures. At the time of pregnancy, female C57BI/6J mice were exposed to either filtered air or 300µg/m3 nPM for 5 hours per day, 3 days per week. Subsequent to the birth of the pups, exposure was maintained in the same fashion until weaning at 4 weeks of age. Thereafter, male and female mice were put on either a regular chow diet (n = 8 males and n = 8 females) or a high fat diet (n = 8 males and n = 8 females) and exposure to filtered air or nPM was maintained in the same fashion for another 10 weeks. This study was completed at the beginning of year 3 in late March 2015. We carried out several non-invasive measurements including body weight and glucose metabolism. We observed that there were no differences in the body weights of female mice in any of the exposed or dietary groups. Therefore, we focused our efforts at the time of sacrifice on characterizing males with respect to adiposity, plasma metabolic biomarkers, and adipose gene expression.
As shown in Figure 1, male mice placed on the on the chow tended to gain more weight after exposure to nPM (panel A) but there were no differences in exposed and unexposed mice on the high fat (data not shown). The increase in body weight in chow-fed males was mostly attributable to increased fat mass but no effects on lean mass, which led to significantly increased adiposity (panel B). Placing the mice in metabolic cages further revealed that those exposed to nPM had increased food intake (FI), suggesting a behavioral component to the effects of exposure, but no differences in energy expenditure (EE) (Panel C). This was accompanied by nPM-exposed mice exhibiting impaired glucose clearance after being administered intraperitoneal glucose tolerance tests, with significantly higher area under the glucose tolerance curve (AUC) than control-exposed mice (Panel D). We next characterized adipose tissue with respect to gene expression and immune cell composition to determine whether changes in these phenotypes could explain the mechanism for the observed whole body physiological differences.
As shown in Figure 2, mRNA levels of insulin receptor (Insr) and insulin receptor substrates 1 and 2 (IRS1, IRS2) were all significantly decreased in adipose tissue of mice exposed to nPM. However, there were no differences in the expression of various adipocytokines (Panel A). Furthermore, there were no differences between the two groups of mice with respect to the number of effector T cells (Teffs), regulatory T cells (Tregs), and type 2 innate lymphoid cells (ILC2s) (Panel B), which have all been shown to modulate inflammation in adipose tissue and contribute to metabolic outcomes. In summary, mice fed a chow fat with exposure to nPM exhibit accumulation of adipose tissue, possibly through increased food intake, and decreased glucose clearance that is likely the result of increased insulin resistance at the level of adipose tissue. However, we do not believe these metabolic abnormalities are due to differences in the inflammatory profile of adipose. The results of these studies will also be of direct relevance to those collected in humans as part of Projects 1 and 2.
Community Outreach and Translation Core
Future Activities:
Project 1: Effects of Air Pollution on the Development of Obesity in Children
The coming year will be focused on successfully completing recruitment.
Project 3: Longitudinal Effects of Air Pollution on Obesity In Mice
Our plans during the fourth year of Project 3 will be to carry out the two additional arms of the exposure studies. These are (1) exposing mice only during prenatal development and (2) exposing mice only during postnatal development. Based on our initial exposure study and feedback from the external advisory committee, we will focus mostly on the chow diet since nPM affected metabolic homeostasis in this setting. However, we will still consider a high fat-fed group of mice as well, possibly by using a diet that has lower fat content. In combination with the results from the already completed whole life exposure study, we expect to obtain additional insight into the critical windows of susceptibility during development that are important for exposure to NRAP. Overall, we do not anticipate any challenges to carrying out the studies in Project 3. Our pilot experiment has already yielded exciting results that are consistent with our hypothesis that NRAP promotes metabolic dysfunction.
Community Outreach and Translation Core
The COTC will continue to work with community partners and the Environmental Committee to host an Environmental Research Summer Institute in June and July, 2016. The partners planning the Institute include Asian and Pacific Islander Obesity Prevention Alliance, and Social Justice Learning Institute. This is a continuing series created to engage a diverse group of local high school youth from Lennox and South LA around environmental health and community research. The program is focused on educating, engaging, and empowering the youth to be agents of change in their own neighborhoods. Youth will learn about environmental health through workshops, presentations, and then placement with one of the community partner organizations to continue their project. The curriculum covered by the COTC includes gathering environmental data, community mapping, monitoring air and noise levels, and an introduction to the nonprofit and government agencies in the area.
Journal Articles: 66 Displayed | Download in RIS Format
Other center views: | All 69 publications | 66 publications in selected types | All 66 journal articles |
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Alderete TL, Autran C, Brekke BE, Knight R, Bode L, Goran MI, Fields DA. Associations between human milk oligosaccharides and infant body composition in the first 6 mo of life. American Journal of Clinical Nutrition 2015;102(6):1381-1388. |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Alderete TL, Habre R, Toledo-Corral CM, Berhane K, Chen Z, Lurmann FW, Weigensberg MJ, Goran MI, Gilliland FD. Longitudinal associations between ambient air pollution with insulin sensitivity, β-cell function, and adiposity in Los Angeles Latino children. Diabetes 2017;66(7):1789-1796. |
R835441 (2018) |
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Alderete TL, Jones RB, Chen Z, Kim JS, Habre R, Lurmann F, Gilliland FD, Goran MI. Exposure to traffic-related air pollution and the composition of the gut microbiota in overweight and obese adolescents. Environmental Research 2018;161:472-478. |
R835441 (2018) R835435 (Final) |
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Alderete TL, Song AY, Bastain T, Habre R, Toledo-Corral CM, Salam MT, Lurmann F, Gilliland FD, Breton CV. Prenatal traffic-related air pollution exposures, cord blood adipokines and infant weight. Pediatric Obesity 2018:13(6):348-356. |
R835441 (2018) R836158 (2017) R836158 (2018) R836158 (2019) R836158 (2020) |
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Allayee H, Hazen SL. Contribution of gut bacteria to lipid levels: another metabolic role for microbes? Circulation Research 2015;117(9):750-754. |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Berger PK, Fields DA, Demerath EW, Fujiwara H, Goran MI. High-fructose corn-syrup-sweetened beverage intake increases 5-hour breast milk fructose concentrations in lactating women. Nutrients 2018;10(6):669 (9 pp.). |
R835441 (2018) |
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Bouret S, Levin BE, Ozanne SE. Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity. Physiological Reviews 2015;95(1):47-82. |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Breton CV, Mack WJ, Yao J, Berhane K, Amadeus M, Lurmann F, Gilliland F, McConnell R, Hodis HN, Kunzli N, Avol E. Prenatal air pollution exposure and early cardiovascular phenotypes in young adults. PLoS One 2016;11(3):e0150825 (12 pp.). |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Burnor E, Cserbik D, Cotter D, Palmer C, Ahmad H, Eckel S, Berhane K, McConnell R, Chen J, Schwartz J, Jackson R, Hertling M. Association of Outdoor Ambient Fine Particulate Matter With Intracellular White Matter Microstructural Properties Among Children. JAMA NETWORK OPEN 2021;4(12). |
R835441 (Final) R835872 (2020) |
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Chen Z, Salam MT, Toledo-Corral C, Watanabe RM, Xiang AH, Buchanan TA, Habre R, Bastain TM, Lurmann F, Wilson JP, Trigo E, Gilliland FD. Ambient air pollutants have adverse effects on insulin and glucose homeostasis in Mexican Americans. Diabetes Care 2016;39(4):547-554. |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Chen Z, Salam MT, Alderete TL, Habre R, Bastain TM, Berhane K, Gilliland FD. Effects of childhood asthma on the development of obesity among school-aged children. American Journal of Respiratory and Critical Care Medicine 2017;195(9):1181-1188. |
R835441 (2018) |
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Cheng H, Davis DA, Hasheminassab S, Sioutas C, Morgan TE, Finch CE. Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFα in vitro. Journal of Neuroinflammation 2016;13:19 (11 pp.). |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Cho J, Goldenson NI, Pester MS, Khoddam R, Bello MS, Dunton GF, Belcher BR, Leventhal AM. Longitudinal associations between anhedonia and body mass index trajectory groups among adolescents. Journal of Adolescent Health 2018;63(1):81-87. |
R835441 (2018) |
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Cotter D, Campbell C, Sukumaran K, McConnell R, Berhane K, Schwartz J, Hackman D, Ahmadi H, Chen J, Herting M. Effects of ambient fine particulates, nitrogen dioxide, and ozone on maturation of functional brain networks across early adolescence. ENVIRONMENT INTERNATIONAL 2023;177(108001) |
R835441 (Final) |
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Cui X, Gong J, Han H, He L, Teng Y, Tetley T, Sinharay R, Chung KF, Islam T, Gilliland F, Grady S, Garshick E, Li Z, Zhang JJ. Relationship between free and total malondialdehyde, a well-established marker of oxidative stress, in various types of human biospecimens. Journal of Thoracic Disease 2018;10(5):3088-3097. |
R835441 (2018) |
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Dueker D, Taher M, Wilson J, McConnell R. Evaluating children's location using a personal GPS logging instrument: limitations and lessons learned. Journal of Exposure Science and Environmental Epidemiology 2014;24(3):244-252. |
R835441 (2015) R835441 (2016) R835441 (2017) R835441 (2018) |
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Dunton GF, O'Connor SG, Belcher BR, Maher JP, Schembre SM. Objectively-measured physical activity and sedentary time are differentially related to dietary fat and carbohydrate intake in children. Frontiers in Public Health 2018;6:198 (6 pp.). |
R835441 (2018) |
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Fruin S, Urman R, Lurmann F, McConnell R, Gauderman J, Rappaport E, Franklin M, Gilliland FD, Shafer M, Gorski P, Avol E. Spatial variation in particulate matter components over a large urban area. Atmospheric Environment 2014;83:211-219. |
R835441 (2015) R835441 (2016) R835441 (2017) R835441 (2018) R831845 (2005) |
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Ghazalpour A, Cespedes I, Bennett BJ, Allayee H. Expanding role of gut microbiota in lipid metabolism. Current Opinion in Lipidology 2016;27(2):141-147. |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Ghosh R, Lurmann F, Perez L, Penfold B, Brandt S, Wilson J, Milet M, Kunzli N, McConnell R. Near-roadway air pollution and coronary heart disease: burden of disease and potential impact of a greenhouse gas reduction strategy in Southern California. Environmental Health Perspectives 2016;124(2):193-200. |
R835441 (2016) |
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Ghosh R, Gauderman WJ, Minor H, Youn HA, Lurmann F, Cromar KR, Chatzi L, Belcher B, Fielding CR, McConnell R. Air pollution, weight loss and metabolic benefits of bariatric surgery: a potential model for study of metabolic effects of environmental exposures. Pediatric Obesity 2018;13(5):312-320. |
R835441 (2017) R835441 (2018) |
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Goran MI, Martin AA, Alderete TL, Fujiwara H, Fields DA. Fructose in breast milk is positively associated with infant body composition at 6 months of age. Nutrients 2017;9(2)146 (11 pp.). |
R835441 (2018) |
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Habre R, Zhou H, Eckel SP, Enebish T, Fruin S, Bastain T, Rappaport E, Gilliland F. Short-term effects of airport-associated ultrafine particle exposure on lung function and inflammation in adults with asthma. Environment International 2018;118:48-59. |
R835441 (2018) |
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Hasson RE, Hsu YJ, Davis JN, Goran MI, Spruijt-Metz D. The influence of parental education on dietary intake in Latino youth. Journal of Immigrant and Minority Health 2018;20(1):250-254. |
R835441 (2018) |
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Hsieh S, Klassen AC, Curriero FC, Caulfield LE, Cheskin LJ, Davis JN, Goran MI, Weigensberg MJ, Spruijt-Metz D. Built environment associations with adiposity parameters among overweight and obese Hispanic youth. Preventive Medicine Reports 2015;2:406-412. |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Hsieh S, Leaderer BP, Feldstein AE, Santoro N, McKay LA, Caprio S, McConnell R. Traffic-related air pollution associations with cytokeratin-18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population. Pediatric Obesity 2018;13(6):342-347. |
R835441 (2017) R835441 (2018) |
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Hsu TM, Konanur VR, Taing L, Usui R, Kayser BD, Goran MI, Kanoski SE. Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats. Hippocampus 2015;25(2):227-239. |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Jerrett M, Shankardass K, Berhane K, Gauderman WJ, Künzli N, Avol E, Gilliland F, Lurmann F, Molitor JN, Molitor JT, Thomas DC, Peters J, McConnell R. Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement. Environmental Health Perspectives 2008;116(10):1433-1438. |
R835441 (2017) R831861 (Final) R831861C001 (Final) R831861C002 (Final) R831861C003 (Final) |
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Jerrett M, McConnell R, Wolch J, Chang R, Lam C, Dunton G, Gilliland F, Lurmann F, Islam T, Berhane K. Traffic-related air pollution and obesity formation in children: a longitudinal, multilevel analysis. Environmental Health 2014;13:49 (9 pp.). |
R835441 (2015) R835441 (2016) R835441 (2018) |
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Johnston J, Juarez Z, Navarro S, Hernandez A, Hutschow W. Youth Engaged Participatory Air Monitoring:A 'Day in the Life' in Urban Environmental Justice Communities. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2020;17(1):93. |
R835441 (Final) |
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Kayser BD, Goran MI, Bouret SG. Perinatal overnutrition exacerbates adipose tissue inflammation caused by high-fat feeding in C57BL/6J mice. PLoS One 2015;10(3):e0121954 (15 pp.). |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Kayser BD, Toledo-Corral CM, Alderete TL, Weigensberg MJ, Goran MI. Temporal relationships between adipocytokines and diabetes risk in Hispanic adolescents with obesity. Obesity 2015;23(7):1479-1485. |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Kim JS, Alderete TL, Chen Z, Lurmann F, Rappaport E, Habre R, Berhane K, Gilliland FD. Longitudinal associations of in utero and early life near-roadway air pollution with trajectories of childhood body mass index. Environmental Health 2018;17(1):64 (10 pp.). |
R835441 (2018) |
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Kim JY, Goran MI, Toledo-Corral CM, Weigensberg MJ, Shaibi GQ. Comparing glycemic indicators of prediabetes: a prospective study of obese Latino Youth. Pediatric Diabetes 2015;16(8):640-643. |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Li L, Lurmann F, Habre R, Urman R, Rappaport E, Ritz B, Chen JC, Gilliland FD, Wu J. Constrained mixed-effect models with ensemble learning for prediction of nitrogen oxides concentrations at high spatiotemporal resolution. Environmental Science & Technology 2017;51(17):9920-9929. |
R835441 (2018) |
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Liao J, Goodrich J, Walker D, Lin Y, Lurmann F, Qiu C, Hones D, Gilliland F, Chazi L, Chen Z. Metabolic pathways altered by air pollutant exposure in association with lipid profiles in young adults*. ENVIRONMENTAL POLLUTION 2023;327(121522) |
R835441 (Final) |
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Lopez NV, Schembre S, Belcher BR, O'Connor S, Maher JP, Arbel R, Margolin G, Dunton GF. Parenting styles, food-related parenting practices, and children's healthy eating: a mediation analysis to examine relationships between parenting and child diet. Appetite 2018;128:205-213. |
R835441 (2018) |
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Luo S, O'Connor SG, Belcher BR, Page KA. Effects of physical activity and sedentary behavior on brain response to high-calorie food cues in young adults. Obesity 2018;26(3):540-546. |
R835441 (2018) |
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Lurmann F, Avol E, Gilliland F. Emissions reduction policies and recent trends in Southern California's ambient air quality. Journal of the Air & Waste Management Association 2015;65(3):324-335. |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Mahmodi G, Bafti R, Boroujeni N, Pradhan S, Danwal S, Sengupta B, Vatanpour V, Sorci M, Fathizadeh M, Bikkina P, Belfort G, Yu M, Kim S. Improving cellulose acetate mixed matrix membranes by incorporating hydrophilic MIL-101(Cr)-NH2 nanoparticles for treating dye/salt solution. CHEMICAL ENGINEERING JOURNAL 2023;477(146736) |
R835441 (Final) R835872 (Final) SU840147 (Final) |
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McConnell R, Shen E, Gilliland FD, Jerrett M, Wolch J, Chang C-C, Lurmann F, Berhane K. A longitudinal cohort study of body mass index and childhood exposure to secondhand tobacco smoke and air pollution: the Southern California Children's Health Study. Environmental Health Perspectives 2015;123(4):360-366. |
R835441 (2015) R835441 (2016) R835441 (2017) R835441 (2018) |
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McConnell R, Gilliland FD, Goran M, Allayee H, Hricko A, Mittelman S. Does near-roadway air pollution contribute to childhood obesity? Pediatric Obesity 2016;11(1):1-3. |
R835441 (2015) R835441 (2016) R835441 (2017) R835441 (2018) |
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Noble EE, Hsu TM, Jones RB, Fodor AA, Goran MI, Kanoski SE. Early-life sugar consumption affects the rat microbiome independently of obesity. The Journal of Nutrition 2017;147(1):20-28. |
R835441 (2018) |
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O'Connor SG, Ke W, Dzubur E, Schembre S, Dunton GF. Concordance and predictors of concordance of children's dietary intake as reported via ecological momentary assessment and 24 h recall. Public Health Nutrition 2018;21(6):1019-1027. |
R835441 (2018) |
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O'Reilly GA, Belcher BR, Davis JN, Martinez LT, Huh J, Antunez-Castillo L, Weigensberg M, Goran MI, Spruijt-Metz D. Effects of high-sugar and high-fiber meals on physical activity behaviors in Latino and African American adolescents. Obesity 2015;23(9):1886-1894. |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Pomatto LCD, Cline M, Woodward N, Pakbin P, Sioutas C, Morgan TE, Finch CE, Forman HJ, Davies KJA. Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles ('vehicular smog'). Free Radical Biology and Medicine 2018;121:86-97. |
R835441 (2018) |
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Ritz B, Qiu J, Lee PC, Lurmann F, Penfold B, Erin Weiss R, McConnell R, Arora C, Hobel C, Wilhelm M. Prenatal air pollution exposure and ultrasound measures of fetal growth in Los Angeles, California. Environmental Research 2014;130:7-13. |
R835441 (2015) R835441 (2016) R835441 (2017) R835441 (2018) |
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Shankardass K, McConnell R, Jerrett M, Lam C, Wolch J, Milam J, Gilliland F, Berhane K. Parental stress increases body mass index trajectory in pre-adolescents. Pediatric Obesity 2014;9(6):435-442. |
R835441 (2015) R835441 (2016) R835441 (2017) R835441 (2018) R831845 (2005) |
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Smallwood T, Allayee H, Bennett BJ. Choline metabolites: gene by diet interactions. Current Opinion in Lipidology 2016;27(1):33-39. |
R835441 (2017) R835441 (2018) |
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Stratakis N, Conti D, Borras E, Sabido E, Roumeliotaki T, Papadopoulou E, Algier L, Basagana X, Bustamante M, Casas M, Farzan S, Fossati S, Gonzalez J, Grazuleviciene R, Heude B, Maitre L, McEachan R, Theologidis I, Urquiza J, Vafeiadi M, West J, Wright J, McConnell R, Brantsaeter A, Meltzer H, Vrijheid M, Chatzi L. Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children. JAMA NETWORK OPEN 2020;3(3):e201007. |
R835441 (Final) |
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Su JG, Jerrett M, McConnell R, Berhane K, Dunton G, Shankardass K, Reynolds K, Chang R, Wolch J. Factors influencing whether children walk to school. Health & Place 2013;22:153-161. |
R835441 (2015) R835441 (2016) R835441 (2017) R835441 (2018) R831845 (2005) |
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Tellez-Rojo MM, Bellinger DC, Arroyo-Quiroz C, Lamadrid-Figueroa H, Mercado-Garcia A, Schnaas-Arrieta L, Wright RO, Hernandez-Avila M, Hu H. Longitudinal associations between blood lead concentrations lower than 10 μg/dL and neurobehavioral development in environmentally exposed children in Mexico City. Pediatrics 2006;118(2):e323-e330. |
R835441 (2017) R831725 (2007) R831725 (2009) |
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Toledo-Corral CM, Alderete TL, Richey J, Sequeira P, Goran MI, Weigensberg MJ. Fasting, post-OGTT challenge, and nocturnal free fatty acids in prediabetic versus normal glucose tolerant overweight and obese Latino adolescents. Acta Diabetologica 2015;52(2):277-284. |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Toledo-Corral CM, Alderete TL, Habre R, Berhane K, Lurmann FW, Weigensberg MJ, Goran MI, Gilliland FD. Effects of air pollution exposure on glucose metabolism in Los Angeles minority children. Pediatric Obesity 2018;13(1):54-62. |
R835441 (2018) |
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Urman R, Gauderman J, Fruin S, Lurmann F, Liu F, Hosseini R, Franklin M, Avol E, Penfold B, Gilliland F, Brunekreef B, McConnell R. Determinants of the spatial distributions of elemental carbon and particulate matter in eight Southern Californian communities. Atmospheric Environment 2014;86:84-92. |
R835441 (2015) R835441 (2016) R835441 (2017) R835441 (2018) |
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Urman R, McConnell R, Islam T, Avol EL, Lurmann FW, Vora H, Linn WS, Rappaport EB, Gilliland FD, Gauderman WJ. Associations of children's lung function with ambient air pollution: joint effects of regional and near-roadway pollutants. Thorax 2014;69(6):540-547. |
R835441 (2015) R835441 (2016) R835441 (2017) R835441 (2018) R831845 (2005) |
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Vos MB, Goran MI. Sugar, sugar ... not so sweet for the liver.Gastroenterology 2017;153(3):642-645. |
R835441 (2018) |
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Wang P, Tuvblad C, Younan D, Franklin M, Lurmann F, Wu J, Baker LA, Chen JC. Socioeconomic disparities and sexual dimorphism in neurotoxic effects of ambient fine particles on youth IQ: a longitudinal analysis. PLoS One 2017;12(12):e0188731 (15 pp.). |
R835441 (2018) |
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Wheelock K, Zhang JJ, McConnell R, Tang D, Volk HE, Wang Y, Herbstman JB, Wang S, Phillips DH, Camann D, Gong J, Perera F. A novel method for source-specific hemoglobin adducts of nitro-polycyclic aromatic hydrocarbons. Environmental Science: Processes & Impacts 2018;20(5):780-789. |
R835441 (2018) |
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Wu W, Muller R, Berhane K, Fruin S, Liu F, Jaspers I, Diaz-Sanchez D, Peden DB, McConnell R. Inflammatory response of monocytes to ambient particles varies by highway proximity. American Journal of Respiratory Cell and Molecular Biology 2014;51(6):802-809. |
R835441 (2015) R835441 (2016) R835441 (2017) R835441 (2018) R831845 (2005) |
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Younan D, Tuvblad C, Li L, Wu J, Lurmann F, Franklin M, Berhane K, McConnell R, Wu AH, Baker LA, Chen JC. Environmental determinants of aggression in adolescents: role of urban neighborhood greenspace. Journal of the American Academy of Child and Adolescent Psychiatry 2016;55(7):591-601. |
R835441 (2018) |
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Younan D, Tuvblad C, Franklin M, Lurmann F, Li L, Wu J, Berhane K, Baker LA, Chen JC. Longitudinal analysis of particulate air pollutants and adolescent delinquent behavior in Southern California. Journal of Abnormal Child Psychology 2018;46(6):1283-1293. |
R835441 (2018) |
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Zigman JM, Bouret SG, Andrews ZB. Obesity impairs the action of the neuroendocrine ghrelin system. Trends in Endocrinology and Metabolism 2016;27(1):54-63. |
R835441 (2016) R835441 (2017) R835441 (2018) |
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Zink J, Belcher BR, Dzubur E, Ke W, O'Connor S, Huh J, Lopez N, Maher JP, Dunton GF. Association between self-reported and objective activity levels by demographic factors: ecological momentary assessment study in children. JMIR mHealth and uHealth 2018;6(6):e150 (12 pp.). |
R835441 (2018) |
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Volk HE, Lurmann F, Penfold B, Hertz-Picciotto I, McConnell R. Traffic related air pollution, particulate matter, and autism. JAMA Psychiatry 2013;70(1):71-77. |
R835441 (2017) R833292 (2012) |
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Cserbik D, Chen JC, McConnell R, Berhane K, Sowell ER, Schwartz J, Hackman DA, Kan E, Fan CC and Herting MM. Fine particulate matter exposure during childhood relates to hemispheric-specific differences in brain structure. Environ Int 2020; 143:105933. |
R835441 (Final) R835872 (2020) |
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Supplemental Keywords:
Children's health, children's environmental health, near-roadway air pollution, NRAP, air pollution, adverse health effects, obesity, air pollutantProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2018 Progress Report
- 2017 Progress Report
- 2015 Progress Report
- 2014 Progress Report
- Original Abstract
66 journal articles for this center