Trichloroacetic acid

CASRN 76-03-9

IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Final Report)


EPA has finalized the Toxicological Review of Trichloroacetic Acid: in support of the Integrated Risk Information System (IRIS). Now final, this assessment may be used by EPA’s program and regional offices to inform decisions to protect human health.


U.S. EPA. IRIS Toxicological Review of Trichloroacetic Acid (TCA) (Final Report). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/003F, 2011.

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The Toxicological Review of Trichloroacetic Acid provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to trichloroacetic acid. Trichloroacetic acid is used as an antiseptic, skin peeling agent, and chemical intermediate to produce a variety of organic chemicals. Trichloroacetic acid is also used industrially as an etching and pickling agent for surface treatment of metals and as a solvent in the plastics industry. Trichloroacetic acid is formed from organic materials during water chlorination.


Date Description
03-Aug 2009EPA hosted an interagency science consultation on the draft Toxicological Review of Trichloroacetic Acid.
04-Sep 2009EPA released an External Reviewer Draft for public comment. EPA also announced a public listening session on Nov 4, 2009 [Federal Register Sep 24, 2009]
05-Nov 2009EPA announced the external peer review meeting to be held on December 10, 2009. [Federal Register Nov 10, 2009]
06-Jan 2010EPA released the comments from the external review workshop.
07-Jul 2011EPA hosted an interagency science discussion on the review of the draft Toxicological Review of Trichloroacetic Acid.
08-Sep 2011EPA releases the final toxicological review and IRIS Summary for Trichloroacetic Acid and the interagency science discussion draft with interagency comments.

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This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.

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