Trichloroacetic acid

CASRN 76-03-9

Health Hazard Assessments for Effects Other than Cancer


Reference Dose for Oral Exposure (RfD) (PDF) (26 pp, 273 K) last updated: 09/30/2011

RfD (mg/kg-day) System Basis PoD Composite UF Confidence
2 x10-2 Hepatic Hepatocellular necrosis BMDL10 : 18
mg/kg-day
1000 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (26 pp, 273 K) last updated: 09/30/2011
Information reviewed but value not estimated.

Cancer Assessment


Weight of Evidence for Cancer (PDF) (26 pp, 273 K) last updated: 09/30/2011

WOE Characterization Framework for WOE Characterization
Suggestive evidence of carcinogenic potential Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (Cancer Guidelines) (U.S. EPA, 2005a), there is suggestive evidence of carcinogenic potential for TCA based on significantly increased incidences of liver tumors in male B6C3F1 mice exposed via drinking water for 52–104 weeks (DeAngelo et al., 2008 Bull et al., 2002, 1990 Herren-Freund et al., 1987) and female B6C3F1 mice exposed for 51 or 82 weeks (Pereira, 1996), and lack of treatment-related tumors in a study of male F344/N rats following lifetime exposure in drinking water (DeAngelo et al., 1997).
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (26 pp, 273 K)

Oral Slope Factor: 7 x10 -2 per mg/kg-day
Drinking Water Unit Risk: 2 x10 -6 per µg/L
Extrapolation Method: Multistage model with linear extrapolation from the POD (LED10).
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenomas or carcinomas (DeAngelo et al. (2008))


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (26 pp, 273 K)

Information reviewed but value not estimated.

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