Trichloroacetic acid

CASRN 76-03-9

IRIS Toxicological Review of Trichloroacetic Acid (TCA) (External Review Draft)

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EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Trichloroacetic acid (TCA) that when finalized will appear on the Integrated Risk Information System (IRIS) database.


U.S. EPA. IRIS Toxicological Review of Trichloroacetic Acid (TCA) (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/003A, 2009.

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The draft Toxicological Review of trichloroacetic acid provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to trichloroacetic acid. Trichloroacetic acid is used as an antiseptic, skin peeling agent, and chemical intermediate to produce a variety of organic chemicals. Trichloroacetic acid is also used industrially as an etching and pickling agent for surface treatment of metals and as a solvent in the plastics industry. Trichloroacetic acid is formed from organic materials during water chlorination.

This assessment contains the derivation of a chronic reference dose and cancer oral slope factor.


Date Description
01-Mar 1996EPA posted the IRIS assessment for trichloroacetic acid on the IRIS database (cancer assessment only).
02-Sep 2009EPA released an external review draft for public review and comment. A public listening session to discuss the report will be held on November 4, 2009.
03-Sep 2009EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of Trichloroacetic Acid.
04-Nov 2009EPA announces the details of an external peer review workshop to be held on December 10, 2009 in a November 10, 2009 Federal Register Notice.
05-Jan 2010EPA releases the comments from the public comment period and external review workshop.


Following external peer review of the report, the final assessment will be posted to the IRIS database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Web site. From the site, select Environmental Protection Agency and the key word EPA-HQ-ORD-2009-0203 (for the docket ID).

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