IRIS

cis-1,2-Dichloroethylene

CASRN 156-59-2

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (16 pp, 182 K) last updated: 09/30/2010

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Urinary, Whole Body Effects 0.002 Increased relative kidney weight in male rats BMDL10 : 5.1
mg/kg-day
3000 Low
Urinary, Whole Body Effects 2 x 10-3 Increased relative kidney weight in male rats BMDL10 : 5.1
mg/kg-day
3000 Low

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (16 pp, 182 K) last updated: 09/30/2010
Information reviewed but value not estimated.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (16 pp, 182 K) last updated: 09/30/2010

WOE Characterization Framework for WOE Characterization
Inadequate information to assess carcinogenic potential Guidelines for Carcinogen Risk Assessment (US EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), there is "inadequate information to assess the carcinogenic potential" of cis-1,2-DCE.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (16 pp, 182 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (16 pp, 182 K)

Not assessed under the IRIS Program.

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