IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (2010 Final)


EPA is announcing the release of the final report, Toxicological Review of cis-1,2-Dichloroethylene: in support of the Integrated Risk Information System (IRIS). The updated Summary for cis and trans-1,2-Dichloroethylene and accompanying Quickview have also been added to the IRIS Web site.

The final Toxicological Review of cis- & trans-1,2-Dichloroethylene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to cis- and trans-1,2-dichloroethylene. 1,2-Dichloroethylene is used as a solvent for waxes and resins, in rubber extraction, and as a coolant in refrigeration plants. The cis- and trans- isomers have slightly different physical, chemical, and biological properties. The trans-isomer is more widely used. 1,2-Dichloroethylene is frequently detected at federal and state hazardous waste sites across the country.


U.S. EPA. IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (2010 Final). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/006F, 2010.

Sep 1988EPA released the assessment for trans-1,2-dichloroethylene (RfD only).
Dec 1990EPA released the assessment for cis-1,2-dichloroethylene (qualitative cancer assessment only).
Aug 2009EPA hosted an interagency science consultation on the review of the draft IRIS Summary and Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene.
Sep 2009EPA released an external review draft of the assessment for public review and comment.
Nov 2009EPA announces the external peer review workshop to be held on December 17, 2009. [Federal Register Notice Nov 10, 2009]
Jan 2010EPA releases the comments from the external review workshop and public comment period.
Jul 2010EPA hosted an interagency science discussion on the review of the draft Toxicological Review of cis- and trans-1,2-dichloroethylene .
Sep 2010EPA releases the final report and IRIS Summary and the interagency review draft with comments.