IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (Interagency Science Discussion Draft)

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EPA is releasing the draft report, Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies and White House Offices are provided below with external peer review panel comments.


U.S. EPA. IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/006D, 2010.

The draft Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to cis- and trans-1,2-dichloroethylene. 1,2-Dichloroethylene is used as a solvent for waxes and resins, in rubber extraction, and as a coolant in refrigeration plants. The cis- and trans- isomers have slightly different physical, chemical, and biological properties. The trans-isomer is more widely used. 1,2-Dichloroethylene is frequently detected at federal and state hazardous waste sites across the country.

Sep 1988EPA released the assessment for trans-1,2-dichloroethylene (RfD only).
Dec 1990EPA released the assessment for cis-1,2-dichloroethylene (qualitative cancer assessment only).
Aug 2009EPA hosted an interagency science consultation on the review of the draft IRIS Summary and Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene.
Sep 2009EPA released an external review draft of the assessment for public review and comment.
Nov 2009EPA announces the external peer review workshop to be held on December 17, 2009. [Federal Register Notice Nov 10, 2009]
Jan 2010EPA releases the comments from the external review workshop and public comment period.
Jul 2010EPA hosted an interagency science discussion on the review of the draft Toxicological Review of cis- and trans-1,2-dichloroethylene.
Sep 2010EPA releases the final report and IRIS Summary and the interagency review draft with comments.

Now that the interagency review draft has been completed and finalized, this assessment has been loaded into the IRIS Web site and Database.