IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Consultation Draft)
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The draft Toxicological Review of cis- and trans-1,2-dichloroethylene provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to cis- and trans-1,2-dichloroethylene. 1,2-Dichloroethylene is used as a solvent for waxes and resins, in rubber extraction, and as a coolant in refrigeration plants. The cis- and trans- isomers have slightly different physical, chemical, and biological properties. The trans-isomer is more widely used. 1,2-Dichloroethylene is frequently detected at federal and state hazardous waste sites across the country.
|Sep 1988||EPA released the assessment for trans-1,2-dichloroethylene (RfD only).|
|Dec 1990||EPA released the assessment for cis-1,2-dichloroethylene (qualitative cancer assessment only).|
|Aug 2009||EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of cis-and trans-1,2-Dichloroethylene . These comments are provided on this web site.|
|Sep 2009||EPA released an External Review Draft of the assessment for public review and comment.|
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