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Environmental Assessment

IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (External Review Draft)

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Archived files are provided for reference purposes only. The file was current when produced, but is no longer maintained and may now be outdated. Persons with disabilities having difficulty accessing archived files may contact the NCEA Webmaster for assistance. Please visit http://epa.gov/ncea to access current information.

Report Information

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of cis- and trans-1,2-dichloroethylene that will appear in the Integrated Risk Information System (IRIS) database.

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Audrey Galizia
  • by phone at:   732-906-6887
  • by fax at:   732-452-6429
  • by email at:  galizia.audrey@epa.gov


The draft Toxicological Review of cis- and trans-1,2-dichloroethylene provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to cis- and trans-1,2-dichloroethylene. 1,2-Dichloroethylene is used as a solvent for waxes and resins, in rubber extraction, and as a coolant in refrigeration plants. The cis- and trans- isomers have slightly different physical, chemical, and biological properties. The trans-isomer is more widely used. 1,2-Dichloroethylene is frequently detected at federal and state hazardous waste sites across the country.


Sep 1988EPA released the assessment for trans-1,2-dichloroethylene (RfD only).
Dec 1990EPA released the assessment for cis-1,2-dichloroethylene (qualitative cancer assessment only).
Aug 2009EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of cis-and trans-1,2-Dichloroethylene.
Sep 2009EPA released an external review draft of the assessment for public review and comment.
Nov 2009EPA announces the details of an external peer review workshop to be held on December 17, 2009 in a November 10, 2009 Federal Register Notice.
Jan 2010EPA releases the comments from the public comment period and external review workshop.

Next Steps

Following external peer review of the report, the final assessment will be posted to the IRIS database.

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2009-0348 (for the docket ID).


U.S. EPA. IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/006, 2009.


This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

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