Science Inventory

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In March 2024, the IRIS Program released the draft IRIS Toxicological Review of Perfluorononanoic Acid (PFNA) and Related Salts for public comment and external peer review. The IRIS assessment of PFNA will undergo an independent external scientific peer review managed by ERG, a c...

Pollution by per- and polyfluorinated alkyl substances (PFAS) is widespread in global water resources and likely to be underestimated, according to global analysis of available PFAS data.

Per- and polyfluoroalkyl substances (PFAS) are widely used, and their fluorinated state contributes to unique uses and stability but also long half-lives in the environment and humans. PFAS have been shown to be toxic, leading to immunosuppression, cancer, and other adverse healt...

<h3>Meeting Objective</h3> <p>To facilitate the independent external peer review of the draft PFAS IRIS assessments, U.S. Environmental Protection Agency (EPA) contracted with ERG to run a public meeting. This website serves as a resource for the peer review activities associa...

With increasing public awareness of PFAS, and their presence in biological and environmental media across the globe, comes a matching increase in the number of PFAS monitoring studies. As more matrices and sample cohorts are examined, there are more opportunities for matrix inter...

<h3>Meeting Objective</h3> <p>To facilitate the independent external peer review of the draft PFAS IRIS assessments, U.S. Environmental Protection Agency (EPA) contracted with ERG to run a public meeting. This website serves as a resource for the peer review activities associa...

Per- and polyfluoroalkyl substances (PFAS) are used in various industrial products; however, they pose serious health risks. In this study, soil, soil gas, and groundwater samples were collected at a PFAS manufacturing facility in New Jersey, USA, to determine the presence and di...

Aqueous film-forming foams (AFFFs) are used in firefighting applications, and often contain per- and polyfluoroalkyl substances (PFAS), which can detrimentally impact environmental and biological health. Incineration is a potential disposal method for AFFFs, which may produce sec...

Systematic evidence mapping for PFAS structures to characterize human health literature for 430 prioritized PFAS. Systematic evidence maps are pre-decisional analyses that use systematic review methods to compile and summarize evidence, but do not include hazard assessment or tox...

The purpose of this letter is to correct previously reported blood serum concentrations for PFO5DoA in people in Wilmington, North Carolina (NC), in 2017-2018 [1]. Perfluoro-3,5,7,9,11-pentaoxadodecanoic acid (known as PFO5DoA; Chemical Abstracts Service Number [CASN] 39492-91-6,...

Non-targeted analysis (NTA) is an increasingly popular technique for characterizing undefined chemical analytes. Generating quantitative NTA (qNTA) concentration estimates requires the use of training data from calibration &ldquo;surrogates,&rdquo; which can yield diminished pred...

Per- and polyfluoroalkyl substances (PFAS) have emerged as high priority contaminants due to their ubiquity and pervasiveness in the environment. Numerous PFAS co-occur across sources of drinking water, including areas of North Carolina (NC) with some detected concentrations abov...

Seven-day sublethal toxicity tests were performed with the freshwater invertebrates&nbsp;Ceriodaphnia dubia,&nbsp;Hyalella azteca, and&nbsp;Chironomus dilutus&nbsp;to determine the effects of per- or polyfluorinated alkyl substances (PFAS) of varying chain length within four clas...

Perfluorooctanoic acid (PFOA) is a toxic and recalcitrant perfluoroalkyl substance commonly detected in the environment. Its low concentration challenges the development of effective degradation techniques, which demands intensive chemical and energy consumption. The recent strin...

Background:&nbsp;A fluorochemical facility near Fayetteville, North Carolina, emitted per- and polyfluoroalkyl ether acids (PFEAs), a subgroup of per- and polyfluoroalkyl substances (PFAS), to air. Objective:&nbsp;Analyze PFAS in private wells near the facility and in blood from ...

Few field methods are available for characterizing source zones impacted with aqueous film forming foam (AFFF). Non-invasive geophysical characterization of AFFF source zone contamination in situ could assist with the delineation and characterization of these sites, allowing for ...

Per- and polyfluoroalkyl substances (PFAS) are regularly found in soils and dusts, both of which can be consumed by children at relatively high amounts. However, there is little data available to model the bioaccessibility of PFAS in soils and dusts when consumed, or to describe ...

Poly- and perfluoroalkyl substances (PFAS) are oxidatively recalcitrant organic synthetic compounds. PFAS are an exceptional group of chemicals that have significant physical characteristics due to the presence of electronegative fluorine. PFAS persists in the environment, bioacc...

The US Environmental Protection Agency is evaluating the ecological and toxicological effects of&nbsp;per- and polyfluorinated chemicals. A number of perfluorinated chemicals have been shown to impact the thyroid axis&nbsp;in vivo&nbsp;suggesting that the thyroid hormone system i...

Landfills manage materials containing per- and polyfluoroalkyl substances (PFAS) from municipal solid waste (MSW) and other waste streams. This manuscript critically reviews state and federal initiatives and peer-reviewed literature to define best practices for managing these was...

Background:&nbsp; Restoration efforts have led to the return of anadromous fish, a potential source of food for the Penobscot Indian Nation, to the previously dammed Penobscot River, Maine.&nbsp; Objective:&nbsp; U.S. Environmental Protection Agency (EPA), in collaboration with t...

Outcome of bench research developing kinetics and selectivity for Anion Exchange Resin and 9 PFAS chemicals

Research on per- and polyfluoroalkyl substances (PFAS) frequently incorporates organofluorine measurements, particularly because they could support a class-based approach to regulation. However, standardized methods for organofluorine analysis in a broad suite of matrices are cur...

Per- and poly-fluoroalkyl substances (PFAS) are a large class of fluorinated carbon chains that include legacy PFAS, such as perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorohexane sulfonate (PFHxS). These compounds indu...

Few studies are available on the environmental and toxicological effects of perfluoroalkyl ether carboxylic acids (PFECAs), such as GenX, which are replacing legacy PFAS in manufacturing processes. To collect initial data on the toxicity and toxicokinetics of a longer-chain PFECA...