Science Inventory

<< Previous

Next >>

Few studies are available on the environmental and toxicological effects of perfluoroalkyl ether carboxylic acids (PFECAs), such as GenX, which are replacing legacy PFAS in manufacturing processes. To collect initial data on the toxicity and toxicokinetics of a longer-chain PFECA...

At least four polyfluorinated organic substances (i.e., 4:2-, 6:2-, 8:2- and 10:2- fluorotelomer alcohols; FTOHs) have sufficient vapor pressure (VP) to be designated as vapor-forming chemicals. Based on current guidance, vapor-forming chemicals warrant investigation for vapor in...

Adding new unit operations to drinking water treatment systems requires consideration of not only efficacy for its design purpose but also cost, water quality characteristics, impact on overall regulatory compliance, and impact of other treatment unit operations. Here, pilot stud...

&nbsp; Samples from 450 homes with shallow private wells throughout the state of Wisconsin (USA) were collected and analyzed for 44 individual per- and polyfluoroalkyl substances (PFAS), general water quality parameters, and indicators of human waste as well as agricultural inf...

It is imperative to develop sampling and analytical methods to characterize FTOHs in indoor air for the development of mass transfer models to quantitatively predict FTOH emissions and transport for exposure assessment and risk management. This standard describes thermal desorpti...

To estimate half-lives for novel fluoroethers, the GenX Exposure Study obtained two serum measurements for per- and polyfluoroalkyl substances (PFAS) for 44 participants of age 12-86 years from North Carolina, collected 5 and 11 months after fluoroether discharges into the drinki...

This update will provide the most current data on private domestic well density in the US. Earlier well data was based on the 2010 census, this update will be developed using the latest 2020 census data. This data is critical to supporting the Underground Storage Tanks program gi...

Partitioning of per- and polyfluoroalkyl substances (PFAS) to indoor materials, including clothing, may prolong the residence time of PFAS indoors and contribute to exposure. During the Indoor PFAS Assessment (IPA) Campaign, we measured concentrations of nine neutral PFAS in air ...

Investigation of per- and polyfluoroalkyl substance (PFAS) health effects is critical due to issues associated with environmental persistence, widespread occurrence, biological half-life, toxicity, and nearly ubiquitous human and environmental exposure.&nbsp; We recently publishe...

Invitrodb version 4.1 represents the fi rst full release of the ToxCast database in a new schema designed toaccommodate the R package dependency, tcplFit2, which is used in curve-fi tti ng and hit-calling of multi -concentrati onresponse data. This invitrodb schema was beta-teste...

Decision makers in the Columbia River Basin (CRB) are currently challenged with identifying and characterizing the extent of per- and polyfluoroalkyl substances (PFAS) contamination and human exposure to PFAS. This work aims to develop and pilot a methodology to help decision mak...

Various groups and researchers, including the authors of this work, have proposed different definitions of what constitutes per- and polyfluoroalkyl substances (PFAS). The different definitions are all based on a structural definition. Although a structural definition is reasonab...

Per- and polyfluoroalkyl substances (PFAS) from aqueous film forming foam (AFFF) can be accidentally backflushed into drinking water systems during firefighting operations or at industrial facilities.  If this contaminated water enters household plumbing systems, homeowners may n...

The scientific foundation for per- and polyfluoroalkyl substances (PFAS) measurements in water, soils, sediments, biosolids, biota, and outdoor air has rapidly expanded, however, there are limited efforts devoted to developing analytical methods to measure vapor-phase PFAS in ind...

Background:&nbsp;The intersection of the topics of high-resolution mass spectrometry (HRMS) and per- and polyfluoroalkyl substances (PFAS) bring together two disparate and complex subjects. Recently non-targeted analysis (NTA) for the discovery of novel PFAS in environmental and ...

In July 2023, the IRIS Program released the draft IRIS Toxicological Review of Perfluorohexanesulfonic Acid (PFHxS) and Related Salts for public comment and external peer review. The IRIS assessment of PFHxS will undergo an independent external scientific peer review managed by E...

Thyroid hormone system disruption (THSD) negatively affects multiple developmental processes and organs. In fish, inhibition of deiodinases, which are enzymes crucial for (in)activating thyroid hormones (THs), leads to impaired swim bladder inflation. Until now, the underlying me...

In March 2024, the draft IRIS Assessment of Perfluorononanoic Acid (PFNA) and Related Salts (Public Comment and External Review Draft) and the draft charge to external peer reviewers were released for a 60-day public review and comment period. The Toxicological Review and charge ...

Lithium bis[(trifluoromethyl)sulfonyl]azanide (HQ-115; CASRN 90076-65-6) and its desalted amide form 1,1,1-Trifluoro-N-[(trifluoromethyl)sulfonyl] methanesulfonamide (TFSI) are members of the group of per and polyfluoroalkyl substances (PFAS).  This toxicity assessment is a writt...

Perfluoropropanoic Acid (PFPrA; CASRN 422-64-0) and its related salts are members of the group of per and polyfluoroalkyl substances (PFAS). This toxicity assessment is a written summary of the potential health effects associated with exposure to PFPrA (hazard identification) and...

Investigating expected levels of per- and polyfluoroalkyl substances (PFAS)  at landfills is often confounded by variable chemistries present with different aqueous sample types.   The objective of the current study was to evaluate relationships between the physical-chemical prop...

This is the first comprehensive study of per- and polyfluoroalkyl substances (PFAS) in a coastal food web of the&nbsp;U.S.&nbsp;North Atlantic, in which we characterize the presence and concentrations of 24 targeted PFAS across 18 marine species from Narragansett Bay, Rhode Islan...

Non-targeted analysis (NTA) and suspect screening analysis (SSA) are powerful techniques that rely on high-resolution mass spectrometry (HRMS) and computational tools to detect and identify unknown or suspected chemicals in the exposome. Fully understanding the chemical exposome ...

Per- and polyfluoroalkyl substances (PFAS) are a group of chemicals that have gained interest because some PFAS have been shown to have deleterious health effects and prolonged environmental and biological persistence. Chemicals classified as PFAS have a wide range of chemical mo...

Per- and polyfluoroalkyl substances (PFAS) are a wide range of chemicals that are used in a variety of consumer and industrial products leading to direct human exposure. Many PFAS are chemically nonreactive and persistent in the environment, resulting in additional exposure from ...