Science Inventory

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The OECD Omics Reporting Framework (OORF) was developed to facilitate the regulatory use of omics data from laboratory-based toxicology studies, which is achieved by means of (i) increasing transparency and reproducibility, and (ii) supporting standardization and harmonization. T...

Datasets for acute aquatic toxicity, acute mammalian toxicity, and bioconcentration factor were compiled from publicly available data sources. Models were developed using QSAR methodologies such as random forest and XGBoost. Feature selection was employed to reduce the number of ...

In this LifeNet Health webinar, Dr. Deisenroth introduces an advanced human in vitro 3D thyroid microtissue model designed to evaluate thyroid hormone disruption, addressing current challenges with existing models. He will discuss the US EPA Endocrine Disruptor Screening Program’...

There is a rich literature highlighting that pathogens are generally better adapted to infect local than novel hosts, and a separate seemingly contradictory literature indicating that novel pathogens pose the greatest threat to biodiversity and public health. Here, using Batracho...

The US EPA uses exposure and toxicity information and risk assessments to protect human health and the environment from known hazards. However, some of the chemicals we are exposed to are unknown, undetected, and unregulated. Discovering the identity of unknown chemicals with mas...

Background: Mechanistic understanding of transient exposures that lead to adverse health outcomes will enhance our ability to recognize biological signatures of disease. Here, we measured the transcriptomic and epigenomic alterations due to exposure to the metabolic reprogramming...

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To cause developmental toxicity, chemical exposures must cause bioactive concentrations in key tissues during susceptible lifestages, including during early fetal development. Next generation chemical risk assessment (NGRA) aims to replace and enhance traditional toxicity testing...

Phenotypic plasticity is the ability of an organism to alter its phenotype in response to environmental cues. This can be adaptive if the cues are reliable predictors of impending conditions and the alterations enhance the organism's ability to capitalize on those conditions. How...

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This software package will build on an existing prototype package to provide standardized and flexible data science workflows for pipelining and databasing HTTr results using open source software tools, including Docker containers to ensure reproducibility and increase the flexib...

Neurite outgrowth is an important precursor to synapse formation and assays for neurite outgrowth are part of an in vitro battery (IVB) of assays for developmental neurotoxicity screening (DNT). This battery of assays evaluates chemical effects on key neurodevelopmental processes...

Background and Purpose: Current in vitro toxicology methods typically rely on exposure of cells to compounds that were added to the culture media. For neurotoxicity, in vitro exposure of rat cortical neural networks plated on multi-well microelectrode array plates (MEAs) have bee...

Background: In vitro new approach methods (NAMs) have been developed for evaluating developmental neurotoxicity (DNT) potential. One such DNT NAM, the Network Formation Assay (NFA), uses a twelve-day exposure model to measure neuronal network activity changes in primary rat corti...

Identifying reliable positive and negative control compounds is integral to determining the sensitivity and specificity of chemical assays. Our laboratory screens chemicals for developmental neurotoxicity potential using assays that assess larval zebrafish locomotor behavior in r...

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Attendees will hear a brief introduction of the Adverse Outcome Pathways (AOP) Wiki&rsquo;s purpose and past use cases