Science Inventory

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Although the offshore water of Lake Michigan has been below the Great Lakes Water Quality Agreement (GLWQA) total phosphorus (TP) spring target concentration of 7 µg L−1 for several decades, higher TP concentrations occur in the nearshore, contributing to the res...

The potential for polycyclic aromatic hydrocarbon (PAH)-related effects in benthic organisms is commonly estimated from organic carbon-normalized sediment concentrations based on equilibrium partitioning (EqP). Although this approach is useful for screening purposes, it may overe...

Thyroid hormones (TH) are important to numerous bodily functions such as development and homeostasis and can be useful bellwethers for identifying biologically disruptive compounds. Research into the effects of environmental pollutants such as pesticides and other endocrine disru...

Time is an important, but underappreciated component in chemical safety decisions. An estimated 15% of the chemicals in domestic commerce have traditional repeated dose toxicity testing data and even fewer have human health assessments that can be used to inform regulatory action...

The developing brain is particularly vulnerable to neurotoxicity, and exposures to environmental neurotoxicants during this period can result in altered brain development. To investigate the effects of chemical exposures on neurodevelopment, human induced-pluripotent stem cell (i...

Presentation at the MPS World Summit conference 2024, Track 2.7: Modeling diversity and population health with MPS. 

Introduction (120/120): The US EPA is developing new approach methodologies (NAMS) to rapidly evaluate thousands of data-poor chemicals for human health hazards. These NAMs include in vitro exposures to investigate chemical metabolism in novel cell systems to inform hazard a...

Accounting for intraspecific and interspecific competition when assessing the effects of chemical and nonchemical stressors is an important uncertainty in ecological risk assessments. We developed novel projection of interspecific competition (PIC) matrices that allow for analysi...

Chemical exposure monitoring has long been performed using targeted analytical methods. These methods are validated to create standardized procedures that can be used by qualified laboratories, ultimately generating reproducible and actionable results. Despite the immense value o...

The US EPA wrote the New Approach Methods Work Plan in 2021 to 1. Develop NAMs to address information gaps, 2. Engage and communicate with stakeholders, 3. Establish scientific confidence and demonstrate application, 4. Develop baselines and metrics, and 5. Evaluate regulatory fl...

Xenobiotic metabolism is a key consideration in evaluating the hazards and risks posed by environmental chemicals. A number of software tools exist that are capable of simulating metabolites, but each reports its predictions in a different format and with varying levels of detail...

Chemicals assessment and management frameworks rely on regulatory toxicity values, which are based on points of departure (POD) identified following rigorous dose–response assessments. Yet, regulatory PODs and toxicity values for inhalation exposure (i.e., reference concent...

The Tap Water Analysis Project was a multi-year study that used targeted and non-targeted analysis (NTA) methods to survey chemical contaminants in drinking water from five regions across the state of California. For the NTA portion of the project, activated carbon point-of-use (...

The OECD Omics Reporting Framework (OORF) was developed to facilitate the regulatory use of omics data from laboratory-based toxicology studies, which is achieved by means of (i) increasing transparency and reproducibility, and (ii) supporting standardization and harmonization. T...

Datasets for acute aquatic toxicity, acute mammalian toxicity, and bioconcentration factor were compiled from publicly available data sources. Models were developed using QSAR methodologies such as random forest and XGBoost. Feature selection was employed to reduce the number of ...

In this LifeNet Health webinar, Dr. Deisenroth introduces an advanced human in vitro 3D thyroid microtissue model designed to evaluate thyroid hormone disruption, addressing current challenges with existing models. He will discuss the US EPA Endocrine Disruptor Screening Program’...

There is a rich literature highlighting that pathogens are generally better adapted to infect local than novel hosts, and a separate seemingly contradictory literature indicating that novel pathogens pose the greatest threat to biodiversity and public health. Here, using Batracho...

The US EPA uses exposure and toxicity information and risk assessments to protect human health and the environment from known hazards. However, some of the chemicals we are exposed to are unknown, undetected, and unregulated. Discovering the identity of unknown chemicals with mas...

Background: Mechanistic understanding of transient exposures that lead to adverse health outcomes will enhance our ability to recognize biological signatures of disease. Here, we measured the transcriptomic and epigenomic alterations due to exposure to the metabolic reprogramming...

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To cause developmental toxicity, chemical exposures must cause bioactive concentrations in key tissues during susceptible lifestages, including during early fetal development. Next generation chemical risk assessment (NGRA) aims to replace and enhance traditional toxicity testing...

Phenotypic plasticity is the ability of an organism to alter its phenotype in response to environmental cues. This can be adaptive if the cues are reliable predictors of impending conditions and the alterations enhance the organism's ability to capitalize on those conditions. How...

This software package will build on an existing prototype package to provide standardized and flexible data science workflows for pipelining and databasing HTTr results using open source software tools, including Docker containers to ensure reproducibility and increase the flexib...

Neurite outgrowth is an important precursor to synapse formation and assays for neurite outgrowth are part of an in vitro battery (IVB) of assays for developmental neurotoxicity screening (DNT). This battery of assays evaluates chemical effects on key neurodevelopmental processes...

Background and Purpose: Current in vitro toxicology methods typically rely on exposure of cells to compounds that were added to the culture media. For neurotoxicity, in vitro exposure of rat cortical neural networks plated on multi-well microelectrode array plates (MEAs) have bee...