Science Inventory

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Druwe, I. AND X. Arzuaga Andino. EPA’s draft IRIS Assessment of PFHxS. Presentation to the external ERG peer review panel. External peer review meeting for the draft PFHxS IRIS assessment, Virtual, DC, February 26 - March 01, 2024.

Shirke, A., E. Radke-Farabaugh, C. Lin, R. Blain, N. Vetter, C. lemeris, p. hartman, H. Hubbard, M. Angrish, X. Arzuaga Andino, J. Congleton, J. Davis, L. Dishaw, R. Jones, R. Judson, J. Kaiser, A. Kraft, L. Lizarraga, Pamela Noyes, G. Patlewicz, M. Taylor, A. Williams, Kristina Chialton, AND L. Carlson. Expanded Systematic Evidence Map for Hundreds of Per- and Polyfluoroalkyl Substances (PFAS) and Comprehensive PFAS Human Health Dashboard. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 132(2):CID: 026001, (2024). https://doi.org/10.1289/EHP13423

Carlson, L., K. Christensen, S. Sagiv, P. Rajan, C. Klocke, P. Lein, E. Coffman, R. Shaffer, E. Yost, X. Arzuaga Andino, P. Factor-Litvak, A. Sergeev, M. Toborek, M. Bloom, J. Trgovcich, T. Jusko, L. Robertson, J. Meeker, A. Keating, R. Blain, R. Silva, S. Snow, C. Lin, K. Shipkowski, B. Ingle, AND G. Lehmann. A Systematic Evidence Map for The Evaluation of Noncancer Health Effects and Exposures to Polychlorinated Biphenyl Mixtures. ENVIRONMENTAL RESEARCH. Elsevier B.V., Amsterdam, Netherlands, 220:115148, (2023). https://doi.org/10.1016/j.envres.2022.115148

Powers, M. AND X. Arzuaga Andino. Using existing assessments for problem formulation in the IRIS Program: Case example for the reassessment of uranium-induced toxicity. Environmental Epi SR group - June Meeting, Virtual, DC, June 20, 2023.

Arzuaga, X. Applying of the key characteristics approach for evidence screening and analysis. From Free Radicals to Key Characteristics Celebrating Research to Action - Past, Present, and Future, NA, DC, June 09 - 10, 2022.

Arzuaga, X., I. Druwe, AND B. Blake. Applying of the key characteristics approach for evidence screening and analysis of benzo[a]pyrene-induced male reproductive toxicity. Society of Toxicology, San Diego, CA, March 27 - 31, 2022.

Blake, B., T. Anderson, X. Arzuaga Andino, AND I. Druwe. Building confidence in mechanistic evidence derived from high throughput assay data in ToxCast to inform hazard evaluation. Systematic Review Community of Practice Meeeting, Durham, NC, July 11, 2023.

Arzuaga, X. How to Conduct Systematic Reviews and Rapid Systematic Reviews. Society of Toxicology, San Diego, CA, March 27 - 31, 2022.

Arzuaga, X., B. Blake, AND I. Druwe. Key characteristics approach for evidence screening and analysis of benzo[a]pyrene-induced male reproductive toxicity. EBTC Monthly Webinar: New Developments in Mechanism-Driven Chemical Assessment, NA, DC, August 30, 2022.

Blake, B., I. Druwe, AND X. Arzuaga. Synthesis of mechanistic evidence for male reproductive toxicity of benzo[a]pyrene using the key characteristics approach in concert with the mode of action framework. The Society of Toxicology Annual Meeting, San Diego, CA, March 27 - 31, 2022.

Carlson, L., M. Angrish, A. Shirke, E. Radke-Farabaugh, B. Schulz, A. Kraft, R. Judson, G. Patlewicz, R. Blain, C. Lin, N. Vetter, C. Lemeris, P. Hartman, H. Hubbard, X. Arzuaga, Allen Davis, L. Dishaw, I. Druwe, H. Hollinger, R. Jones, J. Kaiser, L. Lizarraga, Pamela Noyes, MicheleM Taylor, A. Shapiro, A. Williams, AND K. Thayer. Systematic Evidence Map for Over One Hundred and Fifty Per- and Polyfluoroalkyl Substances (PFAS). ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 130(5):1-20, (2022). https://doi.org/10.1289/EHP10343

Arzuaga, X., I. Druwe, AND B. Blake. Applying the Key Characteristics Approach for Evaluation of Toxicological and Mechanistic Evidence on Benzo[a]Pyrene-Induced Male Reproductive Toxicity. Wayne State University - Pharmacology Department Webinar, NA, NA - Webinar, January 29, 2021.

Druwe, I., B. Blake, Allen Davis, J. Dean, C. Gibbons, J. Lambert, L. Lizarraga, AND X. Arzuaga. Applying the Key Characteristics Approach for the Quantitative Evaluation of the Toxicological and Mechanistic Evidence on Benzo[a]Pyrene-Induced Male Reproductive Toxicity. Birth Defects Research and Prevention Annual Meeting (Virtually), NA, Virtual, June 28 - 30, 2021.

Blake, B., I. Druwe, AND X. Arzuaga. Implementation of the key characteristics of male reproductive toxicants to synthesize mechanistic evidence: a case study of benzo[a]pyrene. Birth Defects Research and Society Prevention Annual Meeting, NA, Virtual Meeting, June 24 - July 01, 2021.

Blake, B., I. Druwe, AND X. Arzuaga. Implementation of the key characteristics of male reproductive toxicity to synthesize mechanistic evidence: a case study of benzo[a]pyrene. Birth Defects Research and Society Prevention Annual Meeting, NA, June 24 - July 01, 2021.

Arzuaga, X. Introduction to Evidence Maps and Overview of the Integrated Risk Information System Program. Webinar - Wayne State Pharmacology Department, NA, NA-Webinar, March 05, 2021.

Arzuaga, X., L. Lizarraga, AND I. Druwe. Introduction to Systematic Review in the Context of Environmental Health Assessments. To be Presented at CompTox Communities of Practice Webinar, Washington, District Of Columbia, May 27, 2021.

Rusyn, I., X. Arzuaga, R. Cattley, C. Corton, S. Ferguson, P. Godoy, K. Guyton, N. Kaplowitz, S. Khetani, R. Roberts, R. Roth, AND M. Smith. Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity. Hepatology. John Wiley & Sons, Inc., Hoboken, NJ, , 3486-3496, (2021). https://doi.org/10.1002/hep.31999

Dishaw, L., E. Yost, X. Arzuaga, A. Luke, A. Kraft, T. Walker, AND K. Thayer. A novel study evaluation strategy in the systematic review of animal toxicology studies for human health assessments of environmental chemicals. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 141:105736, (2020). https://doi.org/10.1016/j.envint.2020.105736

Druwe, I., B. Blake, AND X. Arzuaga. Applying the Key Characteristics Approach for Qualitative and Quantitative Evaluation of the Toxicological and Mechanistic Evidence on Benzo[a]Pyrene-Induced Male Reproductive Toxicity. Society for Risk Analysis, NA, Virtual, December 13 - 17, 2020.

Weaver, J., B. Beverly, Nagalakshmi Keshava, A. Mudipalli, X. Arzuaga Andino, Y. Cai, A. Hotchkiss, S. Makris, AND E. Yost. Hazards of diethyl phthalate (DEP) exposure: A systematic review of animal toxicology studies. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 144:1-24, (2020). https://doi.org/10.1016/j.envint.2020.105848

Druwe, I. AND X. Arzuaga. The Road to Quantification of Adverse Outcome Pathways. Society of Risk Analysis, San Antonio, TX, December 13 - 17, 2020.

Arzuaga, X., T. Walker, E. Yost, E. Radke-Farabaugh, AND A. Hotchkiss. Use of the Adverse Outcome Pathway (AOP) framework to evaluate species concordance and human relevance of Dibutyl Phthalate (DBP)-induced male reproductive toxicity. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 96:445-458, (2020). https://doi.org/10.1016/j.reprotox.2019.06.009

Yost, E., X. Arzuaga Andino, A. Sasso, AND C. Gibbons. Using study evaluation to inform evidence integration: Application in a systematic review of hexavalent chromium male reproductive outcomes. Society of Toxicology 59th Annual Meeting and ToxExpo, Anaheim, California, March 15 - 19, 2020.

Arzuaga Andino, X. AND I. Druwe. Applying the Key Characteristics Approach for Hazard Identification and Risk Assessment of Chemical Induced Cancer and Non-Cancer Effects. Society for Risk Analysis, Arlington, Virginia, December 08 - 12, 2019.