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Applying the Key Characteristics Approach for Hazard Identification and Risk Assessment of Chemical Induced Cancer and Non-Cancer Effects
Citation:
Arzuaga Andino, X. AND I. Druwe. Applying the Key Characteristics Approach for Hazard Identification and Risk Assessment of Chemical Induced Cancer and Non-Cancer Effects. Society for Risk Analysis, Arlington, Virginia, December 08 - 12, 2019.
Impact/Purpose:
This objective of the proposed symposium for the 2019 Society for Risk Analysis annual meeting is to highlight the application of the Key Characteristics paradigm for cancer assessment, and the identification and use of the approach for evaluation of non-cancer health effects. The presentations will describe the scientific basis of Key Characteristics of Carcinogens, Endocrine Disruptors, and Reproductive Toxicants, and describe solutions and case studies to advance research and hazard identification as being applied in national and international settings.
Description:
Analysis of mechanistic evidence as part of a human health assessment can inform biological plausibility and human relevance of effects observed in in-vivo and in-vitro experimental models. Since their identification, the Key Characteristics of Carcinogens have served as an approach for mechanistic evidence screening, organization, and analysis. Smith et al. (Env. Health Perspect. 124: 713, 2016) identified 10 key characteristics which are commonly exhibited by established human carcinogens. The key characteristics are distinct from the hallmarks of cancer, which are the attributes of tumors. The key characteristics instead reflect the properties of a cancer-causing agent. In the cancer hazard identification process, the key characteristics have been used to guide systematic literature searches focused on relevant endpoints. Further, in line with recommendations of the National Academy of Sciences, this paradigm is now being developed for identification of other health hazards, including endocrine disruption and reproductive toxicity. This symposium will highlight the application of the Key Characteristics paradigm for cancer assessment, and the identification and use of the approach for evaluation of non-cancer health effects. The presentations will describe the scientific basis of Key Characteristics of Carcinogens, Endocrine Disruptors, and Reproductive Toxicants, and describe solutions to advance research and hazard identification as being applied in national and international settings. Disclaimer: The views expressed in this abstract are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency.