Science Inventory

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George, BJ, D. Reif, J. Gallagher, C. Williams-DeVane, B. Heindenfelder, E. Hudgens, W. Jones, L. Neas, E. Hubal, AND S. Edwards. Data-driven asthma endotypes defined from blood biomarker and gene expression data. PLOS ONE . Public Library of Science, San Francisco, CA, 10(2):e0117445, (2015).

Edwards, S. AOP Knowledge Base/Wiki Tool Set. Adverse Outcome Pathways, RTP, NC, September 03 - 05, 2014.

Edwards, S. AOPs & Biomarkers: Bridging High Throughput Screening and Regulatory Decision Making. Presented at GEMS, RTP, NC, October 22, 2014.

Edwards, S. AOPs and Biomarkers: Bridging High Throughput Screening and Regulatory Decision Making. Presented at Society of Toxicology, Phoenix, AZ, March 23 - 27, 2014.

Tollefsena, K., S. Scholz, M. Cronin, S. Edwards, J. de Knecht, K. Crofton, N. Garcia-Reyero, T. Hartung, A. Worth, AND C. Patlewicz. Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA workshop report). REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 70(3):629-640, (2014).

Tan, C., D. Chang, M. Phillips, S. Edwards, Chris Grulke, Rocky Goldsmith, J. Sobus, R. Conolly, R. Tornero-Velez, AND C. Dary. Biomarkers in Computational Toxicology. Chapter 63, Biomarkers in Toxicology. Elsevier, Shannon, Ireland, , 1039-1055, (2014).

Bell, S. AND S. Edwards. Building associations between markers of environmental stressors and adverse human health impacts using frequent itemset mining. Presented at SIAM International Conference on Data Mining, Phildelphia, PA, April 24 - 26, 2014.

Bell, S. AND S. Edwards. Developing putative AOPs from high content dataDeveloping putative AOPs from high content dataDeveloping putative AOPs from high content dataDeveloping putative AOPs from high content data. Presented at NIEHS Genomics DAY, RTP, NC, May 01, 2014.

Bell, S. AND S. Edwards. Framework for computationally-predicted AOPs. Presented at Research to Regulations, RTP, NC, September 03 - 05, 2014.

Edwards, S., C. Wittwehr, H. Aladjov, E. Perkins, N. Garcia-Reyero, G. Ankley, D. Lyons, T. Habib, J. DeKnecht, S. Munn, B. Landesmann, M. Whelan, K. Crofton, AND Dan Villeneuve. The adverse outcome pathway knowledge base. SETAC, Vancouver, BC, CANADA, November 09 - 13, 2014.

Edwards, S., D. Reif, E. Hubal, C. Williams-DeVane, B. Heidenfelder, BJ George, AND J. Gallagher. Complex Disease Endotypes and Implications for GWAS and Exposomics***. Presented at PittCon, March 17 - 21, 2013.

Williams-DeVane, C., D. Reif, E. Hubal, P. Bushel, E. Hudgens, J. Gallagher, AND S. Edwards. Decision tree-based method for integrating gene expression, demographic, and clinical data to determine disease endotypes. BMC Systems Biology. BioMed Central Ltd, London, Uk, 7(1):119, (2013).

Gruber, J., R. Patel, J. Rager, A. Sanders, S. Edwards, J. Gallagher, AND R. Fry. Exposure to metals mixtures: Genomic alterations of infectious disease response pathways in children exposed to environmedntal metals. Presented at Society of Toxicology Meeting, San Antonio, TX, March 10 - 14, 2013.

Duncan, K., J. Crooks, D. Miller, L. Burgoon, Mike Schmitt, S. Edwards, D. Diaz-Sanchez, AND R. Devlin. Temporal Profile of Gene Expression Alterations in Primary Human Bronchial Epithelial Cells Following In Vivo Exposure to Ozone. Presented at American Thoracic Society (ATS) Meeting, May 17 - 22, 2013.

Edwards, S., J. Gruber, R. Patel, J. Rager1, A. Sanders, AND R. Fry. Children Exposed to Metals Mixtures Demonstrate Dysregulation of Infectious Disease Response. Presented at Environmetal Mutagen Society, September 08 - 12, 2012.

Lefew, W., R. Conolly, C. Tan, S. Edwards, L. Jackson, AND R. Araujo. Computational Sustainability Tools Illuminating the Triple Value Model. Presented at Society of Toxicology CCT Meeting, May 08 - 11, 2012.

Cordner, A., T. J. WADE, E. A. COHEN-HUBAL, E. E. HUDGENS, S. W. EDWARDS, AND J. GALLAGHER. Impact of environmental chemicals, sociodemographic variables, depression, and clinical indicators of health and nutrition on self-reported health status. Presented at American Public Health Association (APHA) Conference, San Francisco, CA, October 27 - 31, 2012.

Patel, R., J. GALLAGHER, J. Rigdon, AND S. W. EDWARDS. Metal-induced Dysregulation of the NF-kB Pathway in a Detroit Michigan's Children Cohort. Presented at Society of Toxicology (SOT) Annual Meeting, San Francisco, CA, March 11 - 15, 2012.

Gallagher, J., A. Cordner, R. Birch, E. Hudgens, Jeff Inmon, A. Williams, S. Edwards, AND Tim Wade. Towards validating use of self reported health (SRH) for community-based studies: Impact of environmental chemicals, sociodemographic variables, depression, and clinical indicators of health and nutrition. Presented at NC Environmental Justice Summit, October 18 - 19, 2012.

Rountree, N., A. Radadia, C. Williams-DeVane, B. Van Etten, J. Zhang, T. Hughes, BJ George, D. Doerfler, M. Khan, A. Vega, D. Lyons, L. Burgoon, AND S. Edwards. Wiki-based Data Management to Support Systems Toxicology*. Presented at Society of Toxicology CCT Meeting: Building for Better Decisions: Multi-Scale Integration of Human Health and Environmental Data, May 08 - 11, 2012.

Bailey, K. A., K. WALLACE, S. Y. THAI, D. C. WOLF, S. W. EDWARDS, AND R. C. Fry. DIFFERENTIAL MODULATION OF CANCER-RELATED MOLECULAR NETWORKS IN HUMAN AND RAT URINARY BLADDER CELLS EXPOSED TO TRIVALENT ARSENICALS. Presented at Society of Toxicology (SOT) Annual Meeting, Washingtgon, DC, March 06 - 10, 2011.

EDWARDS, S. W. Defining Systems Biology in a Mode of Action Context. Presented at Society of Toxicology, Washington, DC, March 06 - 10, 2011.

Bailey, K. A., K. WALLACE, S. Y. THAI, D. WOLF, S. W. EDWARDS, AND R. C. Fry. Differential modulation of cancer-related molecular networks in human and rat urinary bladder cells exposed to triralent arsenicals. Presented at Society of Toxicology, Washington, DC, March 06 - 10, 2011.

JOUBERT, B., D. REIF, S. W. EDWARDS, K. A. Leiner, E. E. HUDGENS, P. P. EGEGHY, J. GALLAGHER, AND E. A. COHEN-HUBAL. Evaluation of Genetic Susceptibility to Childhood Allergy and Asthma in an African American Urban Population. BMC Genetics. BioMed Central Ltd, London, Uk, 12(25):1-11, (2011).

VILLENEUVE, DAN, G. T. ANKLEY, D. C. BENCIC, J. M. LAZORCHAK, T. W. COLLETTE, D. R. EKMAN, S. W. EDWARDS, N. GARCIA-REYERO, AND E. J. PERKINS. Experimental Approaches to Systematic Discovery and Development of Reproductive Adverse Outcome Pathways in Fish. Presented at Society of Environmental Toxicology and Chemistry, Boston, MA, November 13 - 17, 2011.